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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
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for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
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MetaCyc Enzyme: Rv2509

Gene: Rv2509 Accession Number: RV2509 (MetaCyc)

Synonyms: Probable short-chain type dehydrogenase/reductase

Species: Mycobacterium tuberculosis H37Rv

Summary:
Rv2509 is a potential reductase candidate in the conevrsion of β-oxo-mycolic acid to the mature β-hydroxy mycolic acid in post-Pks13 step of mycolate biosynthesis [LeaSmith07, Bhatt08].

Map Position: [2,824,676 -> 2,825,482]

Molecular Weight of Polypeptide: 28.013 kD (from nucleotide sequence)

Unification Links: Entrez-gene:888562 , UniProt:O01672

Relationship Links: CAZy:IN-FAMILY:CBM14 , InterPro:IN-FAMILY:IPR002557 , Pfam:IN-FAMILY:PF01607 , Prosite:IN-FAMILY:PS50940 , Smart:IN-FAMILY:SM00494

Gene-Reaction Schematic: ?


Enzymatic reaction of: 3-oxo-C87-trans-keto-mycolate-[pks13] reductase (Rv2509)

EC Number: 1.1.-.-

a C87-trans-keto-mycolate-[pks13] + an oxidized electron acceptor <=> a 3-oxo-C87-trans-keto-mycolate-[pks13] + a reduced electron acceptor

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is favored in the opposite direction.

In Pathways: superpathway of mycolate biosynthesis , mycolate biosynthesis


Enzymatic reaction of: 3-oxo-C86-cis-keto-mycolate-[pks13] reductase (Rv2509)

EC Number: 1.1.-.-

a C86-cis-keto-mycolate-[pks13] + an oxidized electron acceptor <=> a 3-oxo-C86-cis-keto-mycolate-[pks13] + a reduced electron acceptor

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is favored in the opposite direction.

In Pathways: superpathway of mycolate biosynthesis , mycolate biosynthesis


Enzymatic reaction of: 3-oxo-C86-trans-methoxy-mycolate-[pks13] reductase (Rv2509)

EC Number: 1.1.-.-

a C86-trans-methoxy-mycolate-[pks13] + an oxidized electron acceptor <=> a 3-oxo-C86-trans-methoxy-mycolate-[pks13] + a reduced electron acceptor

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is favored in the opposite direction.

In Pathways: superpathway of mycolate biosynthesis , mycolate biosynthesis


Enzymatic reaction of: 3-oxo-C85-cis-methoxy-mycolate-[pks13] reductase (Rv2509)

EC Number: 1.1.-.-

a C85-cis-methoxy-mycolate-[pks13] + an oxidized electron acceptor <=> a 3-oxo-C85-cis-methoxy-mycolate-[pks13] + a reduced electron acceptor

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is favored in the opposite direction.

In Pathways: superpathway of mycolate biosynthesis , mycolate biosynthesis


Enzymatic reaction of: 3-oxo-C78-α-mycolate-[pks13] reductase (Rv2509)

EC Number: 1.1.-.-

a C78-α-mycolate-[pks13] + an oxidized electron acceptor <=> a 3-oxo-C78-α-mycolate-[pks13] + a reduced electron acceptor

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is favored in the opposite direction.

In Pathways: superpathway of mycolate biosynthesis , mycolate biosynthesis


References

Bhatt08: Bhatt A, Brown AK, Singh A, Minnikin DE, Besra GS (2008). "Loss of a mycobacterial gene encoding a reductase leads to an altered cell wall containing beta-oxo-mycolic acid analogs and accumulation of ketones." Chem Biol 15(9);930-9. PMID: 18804030

LeaSmith07: Lea-Smith DJ, Pyke JS, Tull D, McConville MJ, Coppel RL, Crellin PK (2007). "The reductase that catalyzes mycolic motif synthesis is required for efficient attachment of mycolic acids to arabinogalactan." J Biol Chem 282(15);11000-8. PMID: 17308303


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Mon Dec 22, 2014, biocyc11.