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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Enzyme: Rv2509

Gene: Rv2509 Accession Number: RV2509 (MetaCyc)

Synonyms: Probable short-chain type dehydrogenase/reductase

Species: Mycobacterium tuberculosis H37Rv

Summary:
Rv2509 is a potential reductase candidate in the conevrsion of β-oxo-mycolic acid to the mature β-hydroxy mycolic acid in post-Pks13 step of mycolate biosynthesis [LeaSmith07, Bhatt08].

Map Position: [2,824,676 -> 2,825,482]

Molecular Weight of Polypeptide: 28.013 kD (from nucleotide sequence)

Unification Links: Entrez-gene:888562 , UniProt:O01672

Relationship Links: CAZy:IN-FAMILY:CBM14 , InterPro:IN-FAMILY:IPR002557 , Pfam:IN-FAMILY:PF01607 , Prosite:IN-FAMILY:PS50940 , Smart:IN-FAMILY:SM00494

Gene-Reaction Schematic: ?


Enzymatic reaction of: 3-oxo-C87-trans-keto-mycolate-[pks13] reductase (Rv2509)

EC Number: 1.1.-.-

a C87-trans-keto-mycolate-[pks13] + an oxidized electron acceptor <=> a 3-oxo-C87-trans-keto-mycolate-[pks13] + a reduced electron acceptor

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is favored in the opposite direction.

In Pathways: superpathway of mycolate biosynthesis , mycolate biosynthesis


Enzymatic reaction of: 3-oxo-C86-cis-keto-mycolate-[pks13] reductase (Rv2509)

EC Number: 1.1.-.-

a C86-cis-keto-mycolate-[pks13] + an oxidized electron acceptor <=> a 3-oxo-C86-cis-keto-mycolate-[pks13] + a reduced electron acceptor

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is favored in the opposite direction.

In Pathways: superpathway of mycolate biosynthesis , mycolate biosynthesis


Enzymatic reaction of: 3-oxo-C86-trans-methoxy-mycolate-[pks13] reductase (Rv2509)

EC Number: 1.1.-.-

a C86-trans-methoxy-mycolate-[pks13] + an oxidized electron acceptor <=> a 3-oxo-C86-trans-methoxy-mycolate-[pks13] + a reduced electron acceptor

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is favored in the opposite direction.

In Pathways: superpathway of mycolate biosynthesis , mycolate biosynthesis


Enzymatic reaction of: 3-oxo-C85-cis-methoxy-mycolate-[pks13] reductase (Rv2509)

EC Number: 1.1.-.-

a C85-cis-methoxy-mycolate-[pks13] + an oxidized electron acceptor <=> a 3-oxo-C85-cis-methoxy-mycolate-[pks13] + a reduced electron acceptor

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is favored in the opposite direction.

In Pathways: superpathway of mycolate biosynthesis , mycolate biosynthesis


Enzymatic reaction of: 3-oxo-C78-α-mycolate-[pks13] reductase (Rv2509)

EC Number: 1.1.-.-

a C78-α-mycolate-[pks13] + an oxidized electron acceptor <=> a 3-oxo-C78-α-mycolate-[pks13] + a reduced electron acceptor

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is favored in the opposite direction.

In Pathways: superpathway of mycolate biosynthesis , mycolate biosynthesis


References

Bhatt08: Bhatt A, Brown AK, Singh A, Minnikin DE, Besra GS (2008). "Loss of a mycobacterial gene encoding a reductase leads to an altered cell wall containing beta-oxo-mycolic acid analogs and accumulation of ketones." Chem Biol 15(9);930-9. PMID: 18804030

LeaSmith07: Lea-Smith DJ, Pyke JS, Tull D, McConville MJ, Coppel RL, Crellin PK (2007). "The reductase that catalyzes mycolic motif synthesis is required for efficient attachment of mycolic acids to arabinogalactan." J Biol Chem 282(15);11000-8. PMID: 17308303


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Nov 23, 2014, BIOCYC13A.