MetaCyc Enzyme: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 1

Gene: apgM1 Accession Number: G-3787 (MetaCyc)

Synonyms: pgm, MJ1612, iPGM

Species: Methanocaldococcus jannaschii

Subunit composition of 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 1 = [ApgM1]4
         phosphoglycerate mutase subunit = ApgM1

The interconversion of 3-phosphoglycerate and 2-phosphoglycerate during glycolysis and gluconeogenesis is catalyzed by phosphoglycerate mutase (PGM). In bacteria and eukaryotes two structurally distinct enzymes have been found, a cofactor-dependent (dPGM) and a cofactor-independent (iPGM) type.

Archaebacteria possess a new family of PGM proteins, distantly related to iPGMs.

Molecular Weight of Polypeptide: 45.226 kD (from nucleotide sequence), 45.2 kD (experimental) [vanderOost02 ]

Molecular Weight of Multimer: 190.6 kD (experimental) [vanderOost02]

Unification Links: Protein Model Portal:Q59007 , String:243232.MJ1612 , UniProt:Q59007

Relationship Links: Entrez-Nucleotide:PART-OF:AAB99632 , InterPro:IN-FAMILY:IPR004456 , InterPro:IN-FAMILY:IPR006124 , InterPro:IN-FAMILY:IPR017849 , InterPro:IN-FAMILY:IPR017850 , InterPro:IN-FAMILY:IPR023665 , Pfam:IN-FAMILY:PF01676 , Pfam:IN-FAMILY:PF10143

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

MultiFun Terms: metabolism carbon utilization carbon compounds

Enzymatic reaction of: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase

EC Number:

2-phospho-D-glycerate <=> 3-phospho-D-glycerate

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

This reaction is reversible.

Activators (Allosteric): Mg2+ [vanderOost02]

Primary Physiological Regulators of Enzyme Activity: Mg2+

Kinetic Parameters:

Km (μM)

T(opt): 90 °C [vanderOost02]

pH(opt): 8 [vanderOost02]


vanderOost02: van der Oost J, Huynen MA, Verhees CH (2002). "Molecular characterization of phosphoglycerate mutase in archaea." FEMS Microbiol Lett 212(1);111-20. PMID: 12076796

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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