Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Enzyme: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 1

Gene: apgM1 Accession Number: G-3787 (MetaCyc)

Synonyms: pgm, MJ1612, iPGM

Species: Methanocaldococcus jannaschii

Subunit composition of 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 1 = [ApgM1]4
         phosphoglycerate mutase subunit = ApgM1

Summary:
The interconversion of 3-phosphoglycerate and 2-phosphoglycerate during glycolysis and gluconeogenesis is catalyzed by phosphoglycerate mutase (PGM). In bacteria and eukaryotes two structurally distinct enzymes have been found, a cofactor-dependent (dPGM) and a cofactor-independent (iPGM) type.

Archaebacteria possess a new family of PGM proteins, distantly related to iPGMs.

Molecular Weight of Polypeptide: 45.226 kD (from nucleotide sequence), 45.2 kD (experimental) [vanderOost02 ]

Molecular Weight of Multimer: 190.6 kD (experimental) [vanderOost02]

Unification Links: UniProt:Q59007

Relationship Links: Entrez-Nucleotide:PART-OF:AAB99632

Gene-Reaction Schematic: ?

MultiFun Terms: metabolism carbon utilization carbon compounds


Enzymatic reaction of: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase

EC Number: 5.4.2.12

2-phospho-D-glycerate <=> 3-phospho-D-glycerate

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

This reaction is reversible.

Activators (Allosteric): Mg2+ [vanderOost02]

Primary Physiological Regulators of Enzyme Activity: Mg2+

Kinetic Parameters:

Substrate
Km (μM)
Citations
3-phospho-D-glycerate
330.0
[vanderOost02]

T(opt): 90 °C [vanderOost02]

pH(opt): 8 [vanderOost02]


References

vanderOost02: van der Oost J, Huynen MA, Verhees CH (2002). "Molecular characterization of phosphoglycerate mutase in archaea." FEMS Microbiol Lett 212(1);111-20. PMID: 12076796


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Wed Dec 17, 2014, biocyc13.