|Gene:||Rv3398c||Accession Number: G-11697 (MetaCyc)|
Species: Mycobacterium tuberculosis H37Rv
ω,E,E-farnesyl diphosphate synthase, encoded by the Rv3398c gene of Mycobacterium tuberculosis H37Rv, is a unique bacterial enzyme that has a structural motif similar to that of the type I geranylgeranyl diphosphate synthase found in Archaea.
From the substrates that were tested, only geranyl diphosphate served as an acceptor for isopentenyl diphosphate. The enzyme has an absolute requirement for divalent cation. Mg2+ was preferable, but Mn2+ and Fe2+ could support catalysis, at lower rates [Dhiman04].
Molecular Weight of Polypeptide: 38.852 kD (from nucleotide sequence)
Relationship Links: InterPro:IN-FAMILY:IPR000092 , InterPro:IN-FAMILY:IPR008949 , InterPro:IN-FAMILY:IPR017446 , Panther:IN-FAMILY:PTHR12001 , Pfam:IN-FAMILY:PF00348 , Prosite:IN-FAMILY:PS00444 , Prosite:IN-FAMILY:PS00723
Enzymatic reaction of: ω,E,E-farnesyl diphosphate synthase
EC Number: 188.8.131.52
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
This reaction is reversible.
pH(opt): 8 [Dhiman04]
Dhiman04: Dhiman RK, Schulbach MC, Mahapatra S, Baulard AR, Vissa V, Brennan PJ, Crick DC (2004). "Identification of a novel class of omega,E,E-farnesyl diphosphate synthase from Mycobacterium tuberculosis." J Lipid Res 45(6);1140-7. PMID: 15060088
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