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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
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MetaCyc Enzyme: aldehyde dehydrogenase

Gene: ipuH Accession Number: G-10338 (MetaCyc)

Species: Pseudomonas sp. KIE171

Summary:
IpuH is similar to NAD-dependent aldehyde dehydrogenases. Based on this sequence similarity and on the fact that the gene is located in the ipu operon, responsible for isopropylamine degradation, the protein has been assigned the function of aldehyde dehydrogenase, potentially catalyzing the conversion of L-2-aminopropionaldehyde to L-alanine, or alternatively, of propanal to propanoate, along with the product of the ipuI gene [deAzevedo02].

This assignment is supported by the observation that in order to obtain a strain that stably accumulates L-alaninol from isopropylamine, it is necessary to inactivate both ipuH and ipuI [deAzevedo02].

Molecular Weight of Polypeptide: 54.078 kD (from nucleotide sequence)

Unification Links: Protein Model Portal:Q936S5 , UniProt:Q936S5

Relationship Links: Entrez-Nucleotide:RELATED-TO:AJ311159 , InterPro:IN-FAMILY:IPR015590 , InterPro:IN-FAMILY:IPR016160 , InterPro:IN-FAMILY:IPR016161 , InterPro:IN-FAMILY:IPR016162 , InterPro:IN-FAMILY:IPR016163 , Pfam:IN-FAMILY:PF00171 , Prosite:IN-FAMILY:PS00070 , Prosite:IN-FAMILY:PS00687

Gene-Reaction Schematic: ?

Credits:
Created 29-Nov-2007 by Caspi R , SRI International


Enzymatic reaction of: propanal:NAD(P)+ oxidoreductase (aldehyde dehydrogenase)

propanal + NAD(P)+ + H2O <=> propanoate + NAD(P)H + 2 H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is favored in the direction shown.

In Pathways: isopropylamine degradation


Enzymatic reaction of: L-2-aminopropionaldehyde:NAD(P)+ oxidoreductase (aldehyde dehydrogenase)

L-2-aminopropionaldehyde + NAD(P)+ + H2O <=> L-alanine + NAD(P)H + 2 H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is favored in the direction shown.

In Pathways: isopropylamine degradation


References

deAzevedo02: de Azevedo Wasch SI, van der Ploeg JR, Maire T, Lebreton A, Kiener A, Leisinger T (2002). "Transformation of isopropylamine to L-alaninol by Pseudomonas sp. strain KIE171 involves N-glutamylated intermediates." Appl Environ Microbiol 68(5);2368-75. PMID: 11976110


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Mon Dec 22, 2014, biocyc11.