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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
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for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
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MetaCyc Enzyme: myo-inositol-1,3,4-trisphosphate 5/6-kinase

Gene: ITPK1 Accession Number: AT5G16760 (MetaCyc)

Synonyms: at5g16760

Species: Arabidopsis thaliana col

Summary:
The Arabidopsis thaliana gene ITPK1 encodes a protein with myo-inositol-1,3,4-trisphosphate 5/6-kinase activity. The gene was recombinantly expressed in E.coli and purified to test its substrate specificity. The enzyme was shown to use D-myo-inositol (1,3,4)-trisphosphate as a substrate to produce both D-myo-inositol (1,3,4,5)-tetrakisphosphate and D-myo-inositol (1,3,4,6)-tetrakisphosphate in a 3:1 ratio [Wilson97]. No evidence of the phosphorylation of D-myo-inositol (1,4,5)-trisphosphate, Ins(1,4)P2, Ins(1)P, Ins(2)P, Ins(3)P or cyclic Ins(1,2)P by the recombinant protein was found [Wilson97].

Molecular Weight of Polypeptide: 36.2 kD (from nucleotide sequence)

Unification Links: Entrez:AAC28859 , ModBase:Q9SBA5 , PhylomeDB:Q9SBA5 , Pride:Q9SBA5 , Protein Model Portal:Q9SBA5 , SMR:Q9SBA5 , Swiss-Model:Q9SBA5 , TAIR:at5g16760 , UniProt:Q9SBA5

Relationship Links: Entrez-Nucleotide:PART-OF:AF080173 , InterPro:IN-FAMILY:IPR008656 , InterPro:IN-FAMILY:IPR011761 , InterPro:IN-FAMILY:IPR017427 , Panther:IN-FAMILY:PTHR14217 , Pfam:IN-FAMILY:PF05770 , Prosite:IN-FAMILY:PS50975

Gene-Reaction Schematic: ?


Enzymatic reaction of: Ins(1,3,4)P3 5-kinase (myo-inositol-1,3,4-trisphosphate 5/6-kinase)

EC Number: 2.7.1.159

D-myo-inositol (1,3,4)-trisphosphate + ATP <=> D-myo-inositol (1,3,4,5)-tetrakisphosphate + ADP + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

The reaction is favored in the direction shown.

In Pathways: superpathway of 1D-myo-inositol hexakisphosphate biosynthesis (plants) , 1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)


Enzymatic reaction of: Ins(1,3,4)P3 6-kinase (myo-inositol-1,3,4-trisphosphate 5/6-kinase)

EC Number: 2.7.1.159

D-myo-inositol (1,3,4)-trisphosphate + ATP <=> D-myo-inositol (1,3,4,6)-tetrakisphosphate + ADP + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

The reaction is favored in the direction shown.

In Pathways: superpathway of 1D-myo-inositol hexakisphosphate biosynthesis (plants) , 1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)


References

Wilson97: Wilson MP, Majerus PW (1997). "Characterization of a cDNA encoding Arabidopsis thaliana inositol 1,3,4-trisphosphate 5/6-kinase." Biochem Biophys Res Commun 232(3);678-81. PMID: 9126335


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Mon Dec 22, 2014, BIOCYC13B.