Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015
twitter

MetaCyc Enzyme: aldehyde reductase

Gene: SDR2 Accession Number: AT2G24190 (MetaCyc)

Synonyms: CytADR

Species: Arabidopsis thaliana col

Summary:
CytADR is an aldehyde reductase (ADR) that catalyzes the reduction of the carbonyl groups on saturated and alpha,beta-unsaturated aldehydes with 5 or more carbons in vitro. It is a member of the short-chain dehydrogenase/reductase (SDR) family of proteins [Yamauchi11].

It is believed that this enzyme localizes to the cytosol like the closely-related ADR protein where they likely help to detoxify reactive carbonyls [Yamauchi11].

Interestingly, in vitro this protein is also able to reduce methylglyoxal, an α-dicarbonyl compound that may be produced during glycolysis, fatty acid metabolism, and protein metabolism [Yamauchi11].

Two chloroplastic (ChlADR and ChlADR) as well as a second cytosolic ADR in Arabidopsis thaliana col with similar enzymatic activity have also been characterized [Yamauchi11].

Map Position: [10,290,714 -> 10,292,060]

Unification Links: PhylomeDB:Q9ZUH5 , Phytozome Plant Orthologs:AT2G24190.2 , Pride:Q9ZUH5 , Protein Model Portal:Q9ZUH5 , SMR:Q9ZUH5 , TAIR:AT2G24190 , UniProt:Q9ZUH5

Relationship Links: InterPro:IN-FAMILY:IPR002198 , InterPro:IN-FAMILY:IPR002347 , InterPro:IN-FAMILY:IPR016040 , Pfam:IN-FAMILY:PF00106 , Prints:IN-FAMILY:PR00080 , Prints:IN-FAMILY:PR00081 , Prosite:IN-FAMILY:PS00061

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Gene Class: UNCLASSIFIED

Credits:
Created 01-Apr-2011 by Dreher KA , TAIR


Enzymatic reaction of: butanal reductase (aldehyde reductase)

Synonyms: butyraldehyde reductase

EC Number: 1.1.1.-

n-butanol + NADP+ <=> butanal + NADPH + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

This reaction is reversible.

Summary:
The kcat for ADR for this reaction is 9.1 s-1 and the kcat/Km is 0.23 s-1 mM-1 [Yamauchi11].

Kinetic Parameters:

Substrate
Km (μM)
Citations
butanal
40000.0
[Yamauchi11]


Enzymatic reaction of: trans-2-hexenal reductase (aldehyde reductase)

EC Number: 1.1.1.-

(E)-2-hexenol + NADP+ <=> (E)-2-hexenal + NADPH + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is favored in the opposite direction.

In Pathways: superpathway of lipoxygenase , traumatin and (Z)-3-hexen-1-yl acetate biosynthesis

Summary:
The kcat for ADR for this reaction is 0.6 s-1 and the kcat/Km is 0.35 s-1 mM-1 [Yamauchi11].

Kinetic Parameters:

Substrate
Km (μM)
Citations
(E)-2-hexenal
1700.0
[Yamauchi11]


Enzymatic reaction of: trans-2-pentenal reductase (aldehyde reductase)

EC Number: 1.1.1.-

(E)-2-pentenol + NADP+ <=> (E)-2-pentenal + NADPH + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is favored in the opposite direction.

Summary:
The kcat for ADR for this reaction is 0.4 s-1 and the kcat/Km is 2.0 s-1 mM-1 [Yamauchi11].

Kinetic Parameters:

Substrate
Km (μM)
Citations
(E)-2-pentenal
200.0
[Yamauchi11]


Enzymatic reaction of: methylglyoxal reductase (aldehyde reductase)

EC Number: 1.1.1.-

acetol + NADP+ <=> methylglyoxal + NADPH + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

This reaction is reversible.

Summary:
The kcat for ADR for this reaction is 24 s-1 and the kcat/Km is 0.35 s-1 mM-1 [Yamauchi11].

Kinetic Parameters:

Substrate
Km (μM)
Citations
methylglyoxal
69000.0
[Yamauchi11]


References

Yamauchi11: Yamauchi Y, Hasegawa A, Taninaka A, Mizutani M, Sugimoto Y (2011). "NADPH-dependent Reductases Involved in the Detoxification of Reactive Carbonyls in Plants." J Biol Chem 286(9);6999-7009. PMID: 21169366


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Mon Aug 31, 2015, biocyc13.