Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Enzyme: 1-pyrroline-5-carboxylate dehydrogenase

Gene: rocA Accession Number: G-278 (MetaCyc)

Species: Bacillus subtilis

Molecular Weight of Polypeptide: 56.32 kD (from nucleotide sequence)

Gene-Reaction Schematic: ?


Enzymatic reaction of: 1-pyrroline-5-carboxylate dehydrogenase

Synonyms: P5C dehydrogenase, Δ1-pyrroline 5-carboxylate dehydrogenase, 1-pyrroline-5-carboxylate:NAD+ oxidoreductase

EC Number: 1.2.1.88

L-glutamate-5-semialdehyde + NAD+ + H2O <=> L-glutamate + NADH + 2 H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction of enzyme catalysis.

The reaction is irreversible in the direction shown.

In Pathways: arginine degradation I (arginase pathway)

Summary:
1-Pyrroline-5-carboxylate dehydrogenase catalyzes the final reaction in the arginine degradation I pathway [Editors93, Gardan97, Gardan95].


References

Editors93: Editors: Abraham L. Sonenshein, James A. Hoch, Richard Losick (1993). "Bacillus subtilis and Other Gram-Positive Bacteria: Biochemistry, Physiology, and Molecular Genetics." American Society For Microbiology, Washington, DC 20005.

Gardan95: Gardan R, Rapoport G, Debarbouille M (1995). "Expression of the rocDEF operon involved in arginine catabolism in Bacillus subtilis." J Mol Biol 1995;249(5);843-56. PMID: 7540694

Gardan97: Gardan R, Rapoport G, Debarbouille M (1997). "Role of the transcriptional activator RocR in the arginine-degradation pathway of Bacillus subtilis." Mol Microbiol 1997;24(4);825-37. PMID: 9194709


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Dec 21, 2014, BIOCYC13B.