Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Enzyme: 1-pyrroline-5-carboxylate dehydrogenase

Gene: rocA Accession Number: G-278 (MetaCyc)

Species: Bacillus subtilis

Molecular Weight of Polypeptide: 56.32 kD (from nucleotide sequence)

Gene-Reaction Schematic: ?


Enzymatic reaction of: 1-pyrroline-5-carboxylate dehydrogenase

Synonyms: P5C dehydrogenase, Δ1-pyrroline 5-carboxylate dehydrogenase, 1-pyrroline-5-carboxylate:NAD+ oxidoreductase

EC Number: 1.2.1.88

L-glutamate-5-semialdehyde + NAD+ + H2O <=> L-glutamate + NADH + 2 H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction of enzyme catalysis.

The reaction is irreversible in the direction shown.

In Pathways: arginine degradation I (arginase pathway)

Summary:
1-Pyrroline-5-carboxylate dehydrogenase catalyzes the final reaction in the arginine degradation I pathway [Editors93, Gardan97, Gardan95].


References

Editors93: Editors: Abraham L. Sonenshein, James A. Hoch, Richard Losick (1993). "Bacillus subtilis and Other Gram-Positive Bacteria: Biochemistry, Physiology, and Molecular Genetics." American Society For Microbiology, Washington, DC 20005.

Gardan95: Gardan R, Rapoport G, Debarbouille M (1995). "Expression of the rocDEF operon involved in arginine catabolism in Bacillus subtilis." J Mol Biol 1995;249(5);843-56. PMID: 7540694

Gardan97: Gardan R, Rapoport G, Debarbouille M (1997). "Role of the transcriptional activator RocR in the arginine-degradation pathway of Bacillus subtilis." Mol Microbiol 1997;24(4);825-37. PMID: 9194709


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Nov 27, 2014, BIOCYC14B.