MetaCyc Enzyme: 1-pyrroline-5-carboxylate dehydrogenase

Gene: rocA Accession Number: G-278 (MetaCyc)

Species: Bacillus subtilis

Molecular Weight of Polypeptide: 56.32 kD (from nucleotide sequence)

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Enzymatic reaction of: 1-pyrroline-5-carboxylate dehydrogenase

Synonyms: P5C dehydrogenase, Δ1-pyrroline 5-carboxylate dehydrogenase, 1-pyrroline-5-carboxylate:NAD+ oxidoreductase

EC Number:

L-glutamate-5-semialdehyde + NAD+ + H2O <=> L-glutamate + NADH + 2 H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is irreversible in the direction shown.

In Pathways: L-arginine degradation I (arginase pathway)

1-Pyrroline-5-carboxylate dehydrogenase catalyzes the final reaction in the arginine degradation I pathway [BSUB93, Gardan97, Gardan95].


BSUB93: "Bacillus subtilis and Other Gram-Positive Bacteria: Biochemistry, Physiology, and Molecular Genetics." (1993). Editors: Sonenshein, A.L., Hoch, J.A., Losick, R. American Society For Microbiology, Washington, DC.

Gardan95: Gardan R, Rapoport G, Debarbouille M (1995). "Expression of the rocDEF operon involved in arginine catabolism in Bacillus subtilis." J Mol Biol 1995;249(5);843-56. PMID: 7540694

Gardan97: Gardan R, Rapoport G, Debarbouille M (1997). "Role of the transcriptional activator RocR in the arginine-degradation pathway of Bacillus subtilis." Mol Microbiol 1997;24(4);825-37. PMID: 9194709

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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