|Gene:||put2||Accession Number: G-447 (MetaCyc)|
Species: Saccharomyces cerevisiae
Δ1-Pyrroline-5-carboxylate dehydrogenase catalyzes the second reaction in proline utilization in Saccharomyces cerevisiae. The two-step pathway takes place inside the mitochondria. The enzyme is encoded in the nucleus, synthesized in the cytoplasm and imported to the mitochondria [Brandriss83, Brandriss79].
Locations: mitochondrial lumen
Molecular Weight of Polypeptide: 64.435 kD (from nucleotide sequence)
Relationship Links: InterPro:IN-FAMILY:IPR005931 , InterPro:IN-FAMILY:IPR015590 , InterPro:IN-FAMILY:IPR016160 , InterPro:IN-FAMILY:IPR016161 , InterPro:IN-FAMILY:IPR016162 , InterPro:IN-FAMILY:IPR016163 , InterPro:IN-FAMILY:IPR029510 , PDB:Structure:4OE4 , PDB:Structure:4OE6 , Pfam:IN-FAMILY:PF00171 , Prosite:IN-FAMILY:PS00070 , Prosite:IN-FAMILY:PS00687
|Cellular Component:||GO:0005759 - mitochondrial matrix [Brandriss81]|
Enzymatic reaction of: Δ1-pyrroline-5-carboxylate dehydrogenase
Synonyms: P5C dehydrogenase
EC Number: 188.8.131.52
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.
The reaction is irreversible in the direction shown.
In Pathways: L-proline degradation
Brandriss81: Brandriss MC, Magasanik B (1981). "Subcellular compartmentation in control of converging pathways for proline and arginine metabolism in Saccharomyces cerevisiae." J Bacteriol 145(3);1359-64. PMID: 7009582
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