MetaCyc Enzyme: cysteine-S-conjugate N-malonyl transferase

Species: Arabidopsis thaliana col

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Created 03-Aug-2011 by Zhang P , PMN

Enzymatic reaction of: cysteine-S-conjugate N-malonyl transferase

EC Number: 2.3.1.-

an L-cysteine-S-conjugate + malonyl-CoA <=> an N-malonyl-L-cysteine-S-conjugate + coenzyme A + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is favored in the direction shown.

In Pathways: glutathione-mediated detoxification II

A measurable cysteine-S-conjugate N-malonyl transferase activity was detected in crude protein extract from Arabidopsis cell suspension culture. N-malonylation was shown towards fenclorim cysteine-S-conjugate. When the cell culture was treated with 100 uM fenclorim for 24 hours, the enzyme activity was found increased 30-fold [BrazierHicks08].

No gene has been identified for this enzyme activity.


BrazierHicks08: Brazier-Hicks M, Evans KM, Cunningham OD, Hodgson DR, Steel PG, Edwards R (2008). "Catabolism of glutathione conjugates in Arabidopsis thaliana. Role in metabolic reactivation of the herbicide safener fenclorim." J Biol Chem 283(30);21102-12. PMID: 18522943

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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