MetaCyc Enzyme: cysteine-S-conjugate N-malonyl transferase

Species: Arabidopsis thaliana col

Gene-Reaction Schematic

Gene-Reaction Schematic

Created 03-Aug-2011 by Zhang P, PMN

Enzymatic reaction of: cysteine-S-conjugate N-malonyl transferase

Inferred from experiment

EC Number: 2.3.1.-

an L-cysteine-S-conjugate + malonyl-CoA → an N-malonyl-L-cysteine-S-conjugate + coenzyme A + H+

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

The reaction is favored in the direction shown.

In Pathways: glutathione-mediated detoxification II

A measurable cysteine-S-conjugate N-malonyl transferase activity was detected in crude protein extract from Arabidopsis cell suspension culture. N-malonylation was shown towards fenclorim cysteine-S-conjugate. When the cell culture was treated with 100 uM fenclorim for 24 hours, the enzyme activity was found increased 30-fold [BrazierHicks08].

No gene has been identified for this enzyme activity.


BrazierHicks08: Brazier-Hicks M, Evans KM, Cunningham OD, Hodgson DR, Steel PG, Edwards R (2008). "Catabolism of glutathione conjugates in Arabidopsis thaliana. Role in metabolic reactivation of the herbicide safener fenclorim." J Biol Chem 283(30);21102-12. PMID: 18522943

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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