|Gene:||ache||Accession Number: G-14654 (MetaCyc)|
Species: Torpedo californica
Subunit composition of
acetylcholinesterase = [Ache]
isoform H = Ache
An essential enzyme of nervous system which rapidly stops the action of acetylcholine that is released into the synapse is acetylcholinesterase. An acetylcholine esterase has been characterized from the pacific ray (Torpedo californica). Two classes have been identified from multipe enxyme forms. Their catalytic action is similar differences lie in amino acid composition, pepride composition and in antibody assays [Schumacher].
Isoform H is a homodimer; has a disulfide-bonded oligomer composed of a collagenic subunit and a variable number of T catalytic subunits. The sequence of this subunit is chosen to be the canonical sequnce
Molecular Weight of Polypeptide: 65.9 kD (from nucleotide sequence), 65.9 kD (experimental)
Relationship Links: InterPro:IN-FAMILY:IPR000908 , InterPro:IN-FAMILY:IPR000997 , InterPro:IN-FAMILY:IPR002018 , InterPro:IN-FAMILY:IPR019819 , InterPro:IN-FAMILY:IPR019826 , PDB:Structure:1ACJ , PDB:Structure:1ACL , PDB:Structure:1AMN , PDB:Structure:1AX9 , PDB:Structure:1CFJ , PDB:Structure:1DX6 , PDB:Structure:1E3Q , PDB:Structure:1E66 , PDB:Structure:1EA5 , PDB:Structure:1EEA , PDB:Structure:1EVE , PDB:Structure:1FSS , PDB:Structure:1GPK , PDB:Structure:1GPN , PDB:Structure:1GQR , PDB:Structure:1GQS , PDB:Structure:1H22 , PDB:Structure:1H23 , PDB:Structure:1HBJ , PDB:Structure:1JGA , PDB:Structure:1JGB , PDB:Structure:1JJB , PDB:Structure:1OCE , PDB:Structure:1ODC , PDB:Structure:1QID , PDB:Structure:1QIE , PDB:Structure:1QIF , PDB:Structure:1QIG , PDB:Structure:1QIH , PDB:Structure:1QII , PDB:Structure:1QIJ , PDB:Structure:1QIK , PDB:Structure:1QIM , PDB:Structure:1QTI , PDB:Structure:1SOM , PDB:Structure:1U65 , PDB:Structure:1UT6 , PDB:Structure:1VOT , PDB:Structure:1VXO , PDB:Structure:1VXR , PDB:Structure:1W4L , PDB:Structure:1W6R , PDB:Structure:1W75 , PDB:Structure:1W76 , PDB:Structure:1ZGB , PDB:Structure:1ZGC , PDB:Structure:2ACE , PDB:Structure:2ACK , PDB:Structure:2BAG , PDB:Structure:2C4H , PDB:Structure:2C58 , PDB:Structure:2C5F , PDB:Structure:2C5G , PDB:Structure:2CEK , PDB:Structure:2CKM , PDB:Structure:2CMF , PDB:Structure:2DFP , PDB:Structure:2J3D , PDB:Structure:2J3Q , PDB:Structure:2J4F , PDB:Structure:2V96 , PDB:Structure:2V97 , PDB:Structure:2V98 , PDB:Structure:2VA9 , PDB:Structure:2VJA , PDB:Structure:2VJB , PDB:Structure:2VJC , PDB:Structure:2VJD , PDB:Structure:2VQ6 , PDB:Structure:2VT6 , PDB:Structure:2VT7 , PDB:Structure:2W6C , PDB:Structure:2W9I , PDB:Structure:2WFZ , PDB:Structure:2WG0 , PDB:Structure:2WG1 , PDB:Structure:2WG2 , PDB:Structure:2XI4 , PDB:Structure:3ACE , PDB:Structure:3GEL , PDB:Structure:3I6M , PDB:Structure:3I6Z , PDB:Structure:3M3D , PDB:Structure:3ZV7 , PDB:Structure:4ACE , Pfam:IN-FAMILY:PF00135 , Prints:IN-FAMILY:PR00878 , Prints:IN-FAMILY:PR00879 , Prosite:IN-FAMILY:PS00122 , Prosite:IN-FAMILY:PS00941
Enzymatic reaction of: acetylcholinesterase
EC Number: 18.104.22.168
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
The reaction is physiologically favored in the direction shown.
Schumacher: Schumacher M, Camp S, Maulet Y, Newton M, MacPhee-Quigley K, Taylor SS, Friedmann T, Taylor P "Primary structure of Torpedo californica acetylcholinesterase deduced from its cDNA sequence." Nature 319(6052);407-9. PMID: 3753747
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