MetaCyc Polypeptide: phthiocerol/phenolphthiocerol synthesis polyketide synthase type I

Gene: ppsA Accession Number: G-15029 (MetaCyc)

Synonyms: β-ketoacyl-acyl-carrier-protein synthase I

Species: Mycobacterium bovis

Catalyzes the condensation of C22-24 fatty acids or p-hydroxyphenylalkanoic acids with malonyl-CoA and methylmalonyl-CoA to yield either phthiocerol and phenolphthiocerol derivatives respectively [Azad97].

Molecular Weight of Polypeptide: 198.84 kD (from nucleotide sequence)

Unification Links: Protein Model Portal:Q7TXM0 , String:233413.Mb2956 , UniProt:Q7TXM0

Relationship Links: InterPro:IN-FAMILY:IPR001227 , InterPro:IN-FAMILY:IPR006162 , InterPro:IN-FAMILY:IPR009081 , InterPro:IN-FAMILY:IPR013968 , InterPro:IN-FAMILY:IPR014030 , InterPro:IN-FAMILY:IPR014031 , InterPro:IN-FAMILY:IPR014043 , InterPro:IN-FAMILY:IPR016035 , InterPro:IN-FAMILY:IPR016036 , InterPro:IN-FAMILY:IPR016038 , InterPro:IN-FAMILY:IPR016039 , InterPro:IN-FAMILY:IPR016040 , InterPro:IN-FAMILY:IPR018201 , InterPro:IN-FAMILY:IPR020801 , InterPro:IN-FAMILY:IPR020806 , InterPro:IN-FAMILY:IPR020841 , InterPro:IN-FAMILY:IPR020842 , Panther:IN-FAMILY:PTHR11712 , Pfam:IN-FAMILY:PF00109 , Pfam:IN-FAMILY:PF00550 , Pfam:IN-FAMILY:PF00698 , Pfam:IN-FAMILY:PF02801 , Pfam:IN-FAMILY:PF08659 , Prosite:IN-FAMILY:PS00012 , Prosite:IN-FAMILY:PS00606 , Prosite:IN-FAMILY:PS50075 , Smart:IN-FAMILY:SM00822 , Smart:IN-FAMILY:SM00823 , Smart:IN-FAMILY:SM00825 , Smart:IN-FAMILY:SM00827

Created 09-Mar-2012 by Weerasinghe D , SRI International


Azad97: Azad AK, Sirakova TD, Fernandes ND, Kolattukudy PE (1997). "Gene knockout reveals a novel gene cluster for the synthesis of a class of cell wall lipids unique to pathogenic mycobacteria." J Biol Chem 272(27);16741-5. PMID: 9201977

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Thu Oct 8, 2015, biocyc13.