MetaCyc Enzyme: peroxisomal choline monooxygenase

Gene: CMO Accession Number: G-14627 (MetaCyc)

Species: Hordeum vulgare

A cDNA clone was isolated from Hordeum vulgare seedlings. The youngest leaves of seedlings were treated to abiotic stress and used for RNA extraction. The cDNA encoded a gene that shared identity with choline monooxygenases (CMO) of higher plants. Subcellular fractionation showed that the barley CMO was localized to peroxisomes. The expression analysis indicated more abundance in leaves, unlike betaine aldehyde dehydrogenase which was more abundant in awns and florets. Choline oxidation in GB synthesis is mediated by a peroxisomal NADPH-dependent choline monooxygenase in barley [Mitsuya11].

Molecular Weight of Polypeptide: 44.7 kD (from nucleotide sequence)

Unification Links: Entrez-Nucleotide:AB434467 , Entrez:BAG74777 , Protein Model Portal:B5UAE1 , UniProt:B5UAE1

Relationship Links: InterPro:IN-FAMILY:IPR001663 , InterPro:IN-FAMILY:IPR015879 , InterPro:IN-FAMILY:IPR017941 , Pfam:IN-FAMILY:PF00355 , Pfam:IN-FAMILY:PF00848 , Prints:IN-FAMILY:PR00090 , Prosite:IN-FAMILY:PS51296

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Created 17-Aug-2011 by Pujar A , Boyce Thompson Institute

Enzymatic reaction of: choline monooxygenase

EC Number: 1.1.1.-

choline + NADP+ <=> betaine aldehyde + NADPH + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Reversibility of this reaction is unspecified.

Enzymatic reaction of: choline monooxygenase

EC Number:

choline + an oxidized unknown electron acceptor <=> betaine aldehyde + an reduced unknown electron acceptor

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

This reaction is reversible.

In Pathways: choline degradation I


Mitsuya11: Mitsuya S, Kuwahara J, Ozaki K, Saeki E, Fujiwara T, Takabe T (2011). "Isolation and characterization of a novel peroxisomal choline monooxygenase in barley." Planta. PMID: 21769646

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Tue Oct 13, 2015, biocyc13.