MetaCyc Enzyme: nicotianamine synthase

Gene: OsNAS3 Accession Number: G-10641 (MetaCyc)

Synonyms: nicotianamine synthase 3

Species: Oryza

A cDNA clone was isolated from rice seedling. The cDNA was recombinantly expressed in transgenic rice plants. The protein was shown to be a nicotianamine synthase and catalyzes the trimerization of SAM into nicotamine [Higuchi01].

Molecular Weight of Polypeptide: 36.9 kD (from nucleotide sequence), 36.9 kD (experimental) [Higuchi01 ]

Unification Links: ArrayExpress:A2YQ58 , Entrez:BAB17824 , Pride:A2YQ58 , Protein Model Portal:A2YQ58 , UniProt:A2YQ58

Relationship Links: Entrez-Nucleotide:PART-OF:AB023819 , InterPro:IN-FAMILY:IPR004298 , InterPro:IN-FAMILY:IPR029063 , Pfam:IN-FAMILY:PF03059 , Prosite:IN-FAMILY:PS51142

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Created 06-May-2008 by Pujar A , Cornell University

Enzymatic reaction of: nicotianamine synthase

EC Number:

3 S-adenosyl-L-methionine <=> L-nicotianamine + 3 S-methyl-5'-thioadenosine + 3 H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

The reaction is favored in the direction shown.

In Pathways: L-nicotianamine biosynthesis , 2'-deoxymugineic acid phytosiderophore biosynthesis


Higuchi01: Higuchi K, Watanabe S, Takahashi M, Kawasaki S, Nakanishi H, Nishizawa NK, Mori S (2001). "Nicotianamine synthase gene expression differs in barley and rice under Fe-deficient conditions." Plant J 25(2);159-67. PMID: 11169192

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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