MetaCyc Enzyme: cycloartenol synthase

Gene: OSCPNX1 Accession Number: G-10241 (MetaCyc)

Synonyms: CAS, oxidosqualene cyclase

Species: Panax ginseng

A cDNA was isolated from suspended cells of hairy roots of Panax ginseng. The cDNA was recombinantly expressed in yeast cells and the molecular weight of the protein was calculated to be 86 kDa [Kushiro98]. The protein was shown to catalyze the conversion of (3S)-2,3-epoxy-2,3-dihydrosqualene to cycloartenol [Kushiro98].

Molecular Weight of Polypeptide: 86.0 kD (from nucleotide sequence)

Unification Links: Entrez:BAA33460 , Protein Model Portal:O82139 , UniProt:O82139

Relationship Links: Entrez-Nucleotide:PART-OF:AB009029 , InterPro:IN-FAMILY:IPR001330 , InterPro:IN-FAMILY:IPR002365 , InterPro:IN-FAMILY:IPR008930 , InterPro:IN-FAMILY:IPR018333 , Pfam:IN-FAMILY:PF00432 , Prosite:IN-FAMILY:PS01074

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

GO Terms:

Molecular Function: GO:0016871 - cycloartenol synthase activity Inferred from experiment [Kushiro98]

Created 15-Oct-2007 by Pujar A , Cornell University

Enzymatic reaction of: cycloartenol synthase

EC Number:

(3S)-2,3-epoxy-2,3-dihydrosqualene <=> cycloartenol

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

The reaction is favored in the direction shown.

Kinetic Parameters:

Specific Activity (U/mg)


Kushiro98: Kushiro T, Shibuya M, Ebizuka Y (1998). "β-amyrin synthase--cloning of oxidosqualene cyclase that catalyzes the formation of the most popular triterpene among higher plants." Eur J Biochem 256(1);238-44. PMID: 9746369

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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