|Gene:||SRM||Accession Number: G-9019 (MetaCyc)|
Species: Homo sapiens
Subunit composition of
spermidine synthase = [SRM]2
spermidine synthase subunit = SRM
The human spermine synthase has been purified to homogeneity and partially characterized [Kajander89]. The enzyme was found in all tissues studied. Very high spermidine synthase activity was present in the pancreas, where it surpassed spermine synthase activity 25-fold. Human kidney contained the highest spermine synthase activity, and in both the kidney and the placenta spermine synthase surpassed spermidine synthase activity 3- and 5-fold respectively.
Thus there are large differences in both synthase activities in various tissues [Kajander89].
Gene Citations: [Wahlfors90]
Molecular Weight of Polypeptide: 33.825 kD (from nucleotide sequence), 35 kD (experimental) [Kajander89 ]
Molecular Weight of Multimer: 62 kD (experimental) [Kajander89]
pI: 5.1 [Kajander89]
Unification Links: ArrayExpress:P19623 , ModBase:P19623 , PhosphoSite:P19623 , PhylomeDB:P19623 , Pride:P19623 , Protein Model Portal:P19623 , SMR:P19623 , String:9606.ENSP00000366156 , Swiss-Model:P19623 , UniProt:P19623
Relationship Links: Entrez-Nucleotide:PART-OF:M34338 , InterPro:IN-FAMILY:IPR001045 , Panther:IN-FAMILY:PTHR11558 , PDB:Structure:2O05 , PDB:Structure:2O06 , PDB:Structure:2O07 , PDB:Structure:2O0L , PDB:Structure:3RW9 , Pfam:IN-FAMILY:PF01564 , Prosite:IN-FAMILY:PS01330 , Prosite:IN-FAMILY:PS51006
Enzymatic reaction of: spermidine synthase
EC Number: 22.214.171.124
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
This reaction is reversible.
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