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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Enzyme: hydroxypyruvate isomerase

Gene: hyi Accession Numbers: G6277 (MetaCyc), b0508, ECK0501

Synonyms: ybbG, gip, glyoxylate-induced protein

Species: Escherichia coli K-12 substr. MG1655

Subunit composition of hydroxypyruvate isomerase = [Hyi]2

Locations: cytosol

Map Position: [534,934 -> 535,710]

Molecular Weight of Polypeptide: 29.377 kD (from nucleotide sequence)

Unification Links: ASAP:ABE-0001756 , DIP:DIP-9994N , EchoBASE:EB1543 , EcoGene:EG11584 , EcoliWiki:b0508 , ModBase:P30147 , OU-Microarray:b0508 , PortEco:hyi , PR:PRO_000022971 , Protein Model Portal:P30147 , RefSeq:NP_415041 , RegulonDB:G6277 , SMR:P30147 , String:511145.b0508 , Swiss-Model:P30147 , UniProt:P30147

Relationship Links: InterPro:IN-FAMILY:IPR013022 , InterPro:IN-FAMILY:IPR017643 , InterPro:IN-FAMILY:IPR026040 , Pfam:IN-FAMILY:PF01261

Gene-Reaction Schematic: ?

GO Terms:

Biological Process: GO:0046487 - glyoxylate metabolic process Inferred from experiment [Ashiuchi99]
Molecular Function: GO:0008903 - hydroxypyruvate isomerase activity Inferred from experiment Inferred by computational analysis [GOA01, Ashiuchi99]
GO:0042803 - protein homodimerization activity Inferred from experiment [Ashiuchi99]
GO:0016853 - isomerase activity Inferred by computational analysis [UniProtGOA11a]
Cellular Component: GO:0005737 - cytoplasm
GO:0005829 - cytosol Inferred by computational analysis [DiazMejia09]

MultiFun Terms: metabolism central intermediary metabolism unassigned reversible reactions

Credits:
Imported from EcoCyc 16-Sep-2014 by Paley S , SRI International


Enzymatic reaction of: hydroxypyruvate isomerase

Synonyms: hydroxypyruvate ketol-isomerase

EC Number: 5.3.1.22

hydroxypyruvate <=> tartronate semialdehyde

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction of enzyme catalysis.

This reaction is reversible.

Credits:
Imported from EcoCyc 16-Sep-2014 by Paley S , SRI International

Summary:
Hydroxypyruvate isomerase exclusively catalyzes the reversible isomerization between hydroxypyruvate and tartronate semialdehyde. [Ashiuchi99]

History:
Markus Krummenacker on Tue Oct 14, 1997:
Gene object created from Blattner lab Genbank (v. M52) entry.


References

Ashiuchi99: Ashiuchi M, Misono H (1999). "Biochemical evidence that Escherichia coli hyi (orf b0508, gip) gene encodes hydroxypyruvate isomerase." Biochim Biophys Acta 1999;1435(1-2);153-9. PMID: 10561547

DiazMejia09: Diaz-Mejia JJ, Babu M, Emili A (2009). "Computational and experimental approaches to chart the Escherichia coli cell-envelope-associated proteome and interactome." FEMS Microbiol Rev 33(1);66-97. PMID: 19054114

GOA01: GOA, MGI (2001). "Gene Ontology annotation based on Enzyme Commission mapping." Genomics 74;121-128.

UniProtGOA11a: UniProt-GOA (2011). "Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Mon Dec 22, 2014, BIOCYC13A.