|Gene:||bcd||Accession Numbers: G-93 (MetaCyc), CA_C2711|
Species: Clostridium acetobutylicum ATCC 824
Butyryl-CoA dehydrogenase, BCD, is an enzyme in the central fermentation pathway of Clostridium acetobutylicum. It plays a central role in the production of both acids and solvents. BCD has not been thoroughly characterized.
The bcd gene, which encodes the enzyme, has been cloned and sequenced [Boynton96a]. There is evidence that BCD interacts with the electron transfer flavoprotein in its redox function [Boynton96a, Woods93].
Molecular Weight of Polypeptide: 41.387 kD (from nucleotide sequence)
Relationship Links: Entrez-Nucleotide:RELATED-TO:U17110 , InterPro:IN-FAMILY:IPR006089 , InterPro:IN-FAMILY:IPR006091 , InterPro:IN-FAMILY:IPR009075 , InterPro:IN-FAMILY:IPR009100 , InterPro:IN-FAMILY:IPR013786 , Pfam:IN-FAMILY:PF00441 , Pfam:IN-FAMILY:PF02770 , Pfam:IN-FAMILY:PF02771 , Prosite:IN-FAMILY:PS00072 , Prosite:IN-FAMILY:PS00073
Enzymatic reaction of: butyryl-CoA dehydrogenase
Synonyms: BCD, butyryl dehydrogenase, acyl-CoA dehydrogenase, short-chain specific, SCAD, unsaturated acyl-CoA reductase, butanoyl-CoA:(acceptor) 2,3-oxidoreductase
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction of enzyme catalysis.
This reaction is reversible.
In Pathways: superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation , superpathway of Clostridium acetobutylicum solventogenic fermentation , superpathway of Clostridium acetobutylicum acidogenic fermentation , pyruvate fermentation to butanol I , pyruvate fermentation to butanoate
Boynton96a: Boynton ZL, Bennet GN, Rudolph FB (1996). "Cloning, sequencing, and expression of clustered genes encoding beta-hydroxybutyryl-coenzyme A (CoA) dehydrogenase, crotonase, and butyryl-CoA dehydrogenase from Clostridium acetobutylicum ATCC 824." J Bacteriol 1996;178(11);3015-24. PMID: 8655474
©2014 SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025-3493