MetaCyc Enzyme: butyryl-CoA dehydrogenase

Gene: bcd Accession Numbers: G-93 (MetaCyc), CA_C2711

Species: Clostridium acetobutylicum ATCC 824

Butyryl-CoA dehydrogenase, BCD, is an enzyme in the central fermentation pathway of Clostridium acetobutylicum. It plays a central role in the production of both acids and solvents. BCD has not been thoroughly characterized.

The bcd gene, which encodes the enzyme, has been cloned and sequenced [Boynton96]. There is evidence that BCD interacts with the electron transfer flavoprotein in its redox function [Boynton96, Woods93].

Molecular Weight of Polypeptide: 41.387 kD (from nucleotide sequence)

Unification Links: Entrez-gene:1118894 , Protein Model Portal:P52042 , SMR:P52042 , String:272562.CA_C2711 , UniProt:P52042

Relationship Links: Entrez-Nucleotide:RELATED-TO:U17110 , InterPro:IN-FAMILY:IPR006089 , InterPro:IN-FAMILY:IPR006091 , InterPro:IN-FAMILY:IPR009075 , InterPro:IN-FAMILY:IPR009100 , InterPro:IN-FAMILY:IPR013786 , Pfam:IN-FAMILY:PF00441 , Pfam:IN-FAMILY:PF02770 , Pfam:IN-FAMILY:PF02771 , Prosite:IN-FAMILY:PS00072 , Prosite:IN-FAMILY:PS00073

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Enzymatic reaction of: butyryl-CoA dehydrogenase

Synonyms: BCD, butyryl dehydrogenase, acyl-CoA dehydrogenase, short-chain specific, SCAD, unsaturated acyl-CoA reductase, butanoyl-CoA:(acceptor) 2,3-oxidoreductase

butanoyl-CoA + an oxidized electron-transfer flavoprotein + H+ <=> crotonyl-CoA + a reduced electron-transfer flavoprotein

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

This reaction is reversible.

In Pathways: superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation , superpathway of Clostridium acetobutylicum solventogenic fermentation , superpathway of Clostridium acetobutylicum acidogenic fermentation , pyruvate fermentation to butanol I , pyruvate fermentation to butanoate

Cofactors or Prosthetic Groups: FAD [Bairoch93a]


Bairoch93a: Bairoch A, Boeckmann B (1993). "The SWISS-PROT protein sequence data bank, recent developments." Nucleic Acids Res. 21:3093-3096. PMID: 8332529

Boynton96: Boynton ZL, Bennet GN, Rudolph FB (1996). "Cloning, sequencing, and expression of clustered genes encoding beta-hydroxybutyryl-coenzyme A (CoA) dehydrogenase, crotonase, and butyryl-CoA dehydrogenase from Clostridium acetobutylicum ATCC 824." J Bacteriol 1996;178(11);3015-24. PMID: 8655474

Woods93: Woods DR (1993). "The Clostridia and Biotechnology Butterworth-Heinemann." Edited by D.R. Woods, Butterworth-Heinemann Publishing, Boston.

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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