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discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Enzyme: proline dehydrogenase 2

Gene: POX2 Accession Number: AT5G38710

Synonyms: PRODH2

Species: Arabidopsis thaliana col

Summary:
Arabidopsis has two functional genes encoding proline dehydrogenase - POX1 and POX2 [Funck10]. The two proteins have non-redundant, although partially overlapping physiological functions. Proline dehydrogenase 1 appears to be the dominant isoform under most conditions and in most tissues, while proline dehydrogenase 2 is specifically upregulated during salt stress (when POX1 is repressed) [Funck10].

proline dehydrogenase 2 is expressed in the vascular tissue and in the abscission zone of petals, sepals, stamina, pistils and siliques. It is Down-regulated by high succrose and up-regulated by L-proline and drought. When expressed in yeast the protein rescued the Pro metabolism defect of a Δput1 mutant strain [Funck10].

Locations: mitochondrion

Map Position: [15,518,475 -> 15,521,339]

Molecular Weight of Polypeptide: 53.074 kD (from nucleotide sequence)

Unification Links: Entrez-gene:833862 , PhylomeDB:Q6NKX1 , Phytozome Plant Orthologs:AT5G38710.1 , Pride:Q6NKX1 , Protein Model Portal:Q6NKX1 , SMR:Q6NKX1 , String:3702.AT5G38710.1-P , TAIR:AT5G38710 , UniProt:Q6NKX1

Relationship Links: InterPro:IN-FAMILY:IPR002872 , InterPro:IN-FAMILY:IPR015659 , Panther:IN-FAMILY:PTHR13914 , Pfam:IN-FAMILY:PF01619

Gene-Reaction Schematic: ?

GO Terms:

Cellular Component: GO:0005739 - mitochondrion [Funck10]

Gene Class: UNCLASSIFIED

Credits:
Created 16-Jun-2010 by Caspi R , SRI International


Enzymatic reaction of: proline dehydrogenase

EC Number: 1.5.5.2

In Pathways: superpathway of citrulline metabolism , L-Nδ-acetylornithine biosynthesis , proline degradation

Cofactors or Prosthetic Groups: FAD


References

Funck10: Funck D, Eckard S, Muller G (2010). "Non-redundant functions of two proline dehydrogenase isoforms in Arabidopsis." BMC Plant Biol 10;70. PMID: 20403182


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Nov 27, 2014, biocyc13.