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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Enzyme: proline dehydrogenase 2

Gene: POX2 Accession Number: AT5G38710

Synonyms: PRODH2

Species: Arabidopsis thaliana col

Summary:
Arabidopsis has two functional genes encoding proline dehydrogenase - POX1 and POX2 [Funck10]. The two proteins have non-redundant, although partially overlapping physiological functions. Proline dehydrogenase 1 appears to be the dominant isoform under most conditions and in most tissues, while proline dehydrogenase 2 is specifically upregulated during salt stress (when POX1 is repressed) [Funck10].

proline dehydrogenase 2 is expressed in the vascular tissue and in the abscission zone of petals, sepals, stamina, pistils and siliques. It is Down-regulated by high succrose and up-regulated by L-proline and drought. When expressed in yeast the protein rescued the Pro metabolism defect of a Δput1 mutant strain [Funck10].

Locations: mitochondrion

Map Position: [15,518,475 -> 15,521,339]

Molecular Weight of Polypeptide: 53.074 kD (from nucleotide sequence)

Unification Links: Entrez-gene:833862 , PhylomeDB:Q6NKX1 , Phytozome Plant Orthologs:AT5G38710.1 , Pride:Q6NKX1 , Protein Model Portal:Q6NKX1 , SMR:Q6NKX1 , String:3702.AT5G38710.1-P , TAIR:AT5G38710 , UniProt:Q6NKX1

Relationship Links: InterPro:IN-FAMILY:IPR002872 , InterPro:IN-FAMILY:IPR015659 , Panther:IN-FAMILY:PTHR13914 , Pfam:IN-FAMILY:PF01619

Gene-Reaction Schematic: ?

GO Terms:

Cellular Component: GO:0005739 - mitochondrion [Funck10]

Gene Class: UNCLASSIFIED

Credits:
Created 16-Jun-2010 by Caspi R , SRI International


Enzymatic reaction of: proline dehydrogenase

EC Number: 1.5.5.2

In Pathways: superpathway of citrulline metabolism , L-Nδ-acetylornithine biosynthesis , proline degradation

Cofactors or Prosthetic Groups: FAD


References

Funck10: Funck D, Eckard S, Muller G (2010). "Non-redundant functions of two proline dehydrogenase isoforms in Arabidopsis." BMC Plant Biol 10;70. PMID: 20403182


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Dec 21, 2014, biocyc13.