Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
twitter

MetaCyc Enzyme: copper-containing amine oxidase

Gene: ATAO1 Accession Number: AT4G14940 (MetaCyc)

Synonyms: at4g14940, diamine oxidase, polyamine oxidase

Species: Arabidopsis thaliana col

Summary:
The Arabidopsis protein encoded by AtAO1 is a copper-containing amine oxidase. Cell extracts of AtAO1-transgenic insect cells incubated with putrescine showed significant activity which was reduced by pre-treatment with semi-carbazide, a specific and irreversible inhibitor of copper amine oxidases. Incubation with spermidine resulted in a lower activity.

Locations: nucleus

Molecular Weight of Polypeptide: 75.0 kD (experimental) [Moller98 ]

Unification Links: ArrayExpress:O48552 , Entrez:AAB87690 , Pride:O48552 , Protein Model Portal:O48552 , String:O48552 , TAIR:at4g14940 , UniProt:O48552

Relationship Links: Entrez-Nucleotide:PART-OF:AF034579 , InterPro:IN-FAMILY:IPR000269 , InterPro:IN-FAMILY:IPR015798 , InterPro:IN-FAMILY:IPR015800 , InterPro:IN-FAMILY:IPR015801 , InterPro:IN-FAMILY:IPR015802 , InterPro:IN-FAMILY:IPR016182 , Panther:IN-FAMILY:PTHR10638 , Pfam:IN-FAMILY:PF01179 , Pfam:IN-FAMILY:PF02727 , Pfam:IN-FAMILY:PF02728 , Prosite:IN-FAMILY:PS01164

Gene-Reaction Schematic: ?

GO Terms:

Cellular Component: GO:0005634 - nucleus [Moller98]

Credits:
Revised 23-Feb-2010 by Zhang P


Enzymatic reaction of: copper amine oxidase (copper-containing amine oxidase)

an aliphatic amine + H2O + oxygen <=> an aldehyde + ammonium + hydrogen peroxide

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

The reaction is physiologically favored in the direction shown.

Inhibitors (Irreversible): semicarbazide [Moller98]


Enzymatic reaction of: putrescine oxidase (copper-containing amine oxidase)

EC Number: 1.4.3.10

putrescine + oxygen + H2O <=> ammonium + hydrogen peroxide + 4-aminobutanal

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

The reaction is physiologically favored in the direction shown.

In Pathways: putrescine degradation IV

Inhibitors (Irreversible): semicarbazide [Moller98]


References

Moller98: Moller SG, McPherson MJ (1998). "Developmental expression and biochemical analysis of the Arabidopsis atao1 gene encoding an H2O2-generating diamine oxidase." Plant J 13(6);781-91. PMID: 9681017


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Tue Nov 25, 2014, BIOCYC13B.