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MetaCyc Compound: sodium chloride

Superclasses: a saltan inorganic salt
an inorganic compoundan inorganic salt

Chemical Formula: NaCl

Molecular Weight: 58.443 Daltons

Salt Constituents: chloride, Na+

Unification Links: ChEBI:26710, ChemSpider:5044, KEGG:C13563, PubChem:5234

Enzymes activated by sodium chloride, sorted by the type of activation, are:

Activator (Mechanism unknown) of: (+)-secoisolariciresinol monoglucoside glucosyltransferase [Ghose14], (+)-secoisolariciresinol glucosyltransferase [Ghose14], 4,6,8-trihydroxydibenzodiazepinone farnesyltransferase [Bonitz13], diacylglycerol kinase [GomezMerino05], D-xylose dehydrogenase [Johnsen04]

Enzymes inhibited by sodium chloride, sorted by the type of inhibition, are:

Inhibitor (Mechanism unknown) of: DD-endopeptidase [Romeis94], UDP-glucose:13-glucosyloxydocosanoate glucosyltransferase [Breithaupt82], UDP-glucose:13-hydroxydocosanoate glucosyltransferase [Breithaupt82], 2-keto-3-deoxy-D-glycero-D-galacto-nononate-9-phosphate synthase [Angata99], phosphoenolpyruvate carboxylase [Patel04], 3-hydroxymethylcephem O-carbamoyltransferase [Brewer80], UDP-D-glucuronic acid 4-epimerase [Gu04], hydrogenase [Keefe95], ADP-dependent phosphofructokinase [Tuininga99], uroporphyrinogen III cosynthetase [Stevens68]


Angata99: Angata T, Nakata D, Matsuda T, Kitajima K, Troy FA (1999). "Biosynthesis of KDN (2-keto-3-deoxy-D-glycero-D-galacto-nononic acid). Identification and characterization of a KDN-9-phosphate synthetase activity from trout testis." J Biol Chem 274(33);22949-56. PMID: 10438460

Bonitz13: Bonitz T, Zubeil F, Grond S, Heide L (2013). "Unusual N-prenylation in diazepinomicin biosynthesis: the farnesylation of a benzodiazepine substrate is catalyzed by a new member of the ABBA prenyltransferase superfamily." PLoS One 8(12);e85707. PMID: 24376894

Breithaupt82: Breithaupt TB, Light RJ (1982). "Affinity chromatography and further characterization of the glucosyltransferases involved in hydroxydocosanoic acid sophoroside production in Candida bogoriensis." J Biol Chem 257(16);9622-8. PMID: 6213610

Brewer80: Brewer SJ, Taylor PM, Turner MK (1980). "An adenosine triphosphate-dependent carbamoylphosphate--3-hydroxymethylcephem O-carbamoyltransferase from Streptomyces clavuligerus." Biochem J 185(3);555-64. PMID: 6248024

Ghose14: Ghose K, Selvaraj K, McCallum J, Kirby CW, Sweeney-Nixon M, Cloutier SJ, Deyholos M, Datla R, Fofana B (2014). "Identification and functional characterization of a flax UDP-glycosyltransferase glucosylating secoisolariciresinol (SECO) into secoisolariciresinol monoglucoside (SMG) and diglucoside (SDG)." BMC Plant Biol 14(1);82. PMID: 24678929

GomezMerino05: Gomez-Merino FC, Arana-Ceballos FA, Trejo-Tellez LI, Skirycz A, Brearley CA, Dormann P, Mueller-Roeber B (2005). "Arabidopsis AtDGK7, the smallest member of plant diacylglycerol kinases (DGKs), displays unique biochemical features and saturates at low substrate concentration: the DGK inhibitor R59022 differentially affects AtDGK2 and AtDGK7 activity in vitro and alters plant growth and development." J Biol Chem 280(41);34888-99. PMID: 16081412

Gu04: Gu X, Bar-Peled M (2004). "The biosynthesis of UDP-galacturonic acid in plants. Functional cloning and characterization of Arabidopsis UDP-D-glucuronic acid 4-epimerase." Plant Physiol 136(4);4256-64. PMID: 15563616

Johnsen04: Johnsen U, Schonheit P (2004). "Novel xylose dehydrogenase in the halophilic archaeon Haloarcula marismortui." J Bacteriol 186(18);6198-207. PMID: 15342590

Keefe95: Keefe RG, Axley MJ, Harabin AL (1995). "Kinetic mechanism studies of the soluble hydrogenase from Alcaligenes eutrophus H16." Arch Biochem Biophys 1995;317(2);449-56. PMID: 7893162

Patel04: Patel HM, Kraszewski JL, Mukhopadhyay B (2004). "The phosphoenolpyruvate carboxylase from Methanothermobacter thermautotrophicus has a novel structure." J Bacteriol 186(15);5129-37. PMID: 15262949

Romeis94: Romeis T, Holtje JV (1994). "Penicillin-binding protein 7/8 of Escherichia coli is a DD-endopeptidase." Eur J Biochem 224(2);597-604. PMID: 7925376

Stevens68: Stevens E, Frydman B (1968). "Isolation and properties of wheat germ uroporphyrinogen 3 cosynthetase." Biochim Biophys Acta 151(2);429-37. PMID: 5636375

Tuininga99: Tuininga JE, Verhees CH, van der Oost J, Kengen SW, Stams AJ, de Vos WM (1999). "Molecular and biochemical characterization of the ADP-dependent phosphofructokinase from the hyperthermophilic archaeon Pyrococcus furiosus." J Biol Chem 274(30);21023-8. PMID: 10409652

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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