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MetaCyc Compound: K+

Synonyms: potassium, potassium ion

Superclasses: an iona cationan inorganic cationa monovalent inorganic cation
an ionan inorganic ionan inorganic cationa monovalent inorganic cation

Component of:
dipotassium phosphate
monopotassium phosphate
potassium cyanide
potassium chloride
potassium sulfate

Molecular Weight: 39.098 Daltons

Monoisotopic Molecular Weight: 38.9637069 Daltons


InChI: InChI=1S/K/q+1


Unification Links: ChEBI:29103, ChemSpider:791, HMDB:HMDB00586, IAF1260:34349, KEGG:C00238, MetaboLights:MTBLC29103, PubChem:813

Standard Gibbs Free Energy of Formation (ΔfG in kcal/mol): -0.3120594Inferred by computational analysis [Latendresse13]

In Transport reactions:
K+[extracellular space]K+[cytosol],
K+[extracellular space]K+[unknown space],
K+[extracellular space] + Na+[cytosol]K+[cytosol] + Na+[extracellular space],
ATP + K+[out] + H2O + H+[in] → ADP + K+[in] + phosphate + H+[in] + H+[in],
ATP + K+[out] + H2O ↔ ADP + K+[in] + phosphate + H+,
2 K+[extracellular space] + 3 Na+[cytosol] + ATP + H2O → 2 K+[cytosol] + 3 Na+[extracellular space] + ADP + phosphate + H+,
K+[cytosol] + H+[periplasm]K+[periplasm] + H+[cytosol],
K+[periplasm] + H+[periplasm]K+[cytosol] + H+[cytosol],
K+[periplasm] + ATP + H2O → K+[cytosol] + ADP + phosphate + H+

Enzymes activated by K+, sorted by the type of activation, are:

Activator (Allosteric) of: acetyl-CoA acetyltransferase [Haapalainen07], GTP cyclohydrolase [Graham02a], S-adenosylmethionine synthetase, unsaturated CDP-archaeol synthase [Morii00], glycerol-1-phosphate dehydrogenase [Nishihara97], aldehyde dehydrogenase, aldehyde dehydrogenase [Wang97c], β-methyl-D-malate hydro-lyase (2-methylmaleate-forming) [Drevland07], propionyl-CoA synthase [Alber02], glutathione synthetase [Nakagawa93], betaine aldehyde dehydrogenase [Boch97], glycerate 2-kinase [Yoshida92], 5-oxo-L-prolinase, 5-oxo-L-prolinase [Seddon85], N-methylhydantoin amidohydrolase [Ogawa95], glucose dehydrogenase [Bonete96a], tryptophanase [Hoch66], F420-0-glutamyl ligase [Li03a], F420-1:γ-glutamyl ligase [Li03a], 2-methylacetoacetyl-CoA thiolase [Sovik93], porphobilinogen synthase [Nandi68], formate--tetrahydrofolate ligase [MacKenzie71], NADP-dependent glyceraldehyde-3-phosphate dehydrogenase [Crow79], pyruvate kinase [Abbe83], tartrate dehydrogenase [Kohn68] Activator (Non-allosteric) of: citrate synthase, aspartate kinase [Moir77] Activator (Mechanism unknown) of: GTP cyclohydrolase [Schoedon92], nicotinate-mononucleotide adenylyltransferase [Dahmen67], glyoxylate carboligase [Gupta66, Comment 1], homoserine dehydrogenase [Ogilvie75, Wedler93], UDP-N-acetylenolpyruvoylglucosamine reductase [Dhalla95, Shapiro12, Comment 2], UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase [Michaud90, Comment 3], IMP dehydrogenase [Kerr00, Comment 4], thiamine monophosphate kinase [Nishino72, Comment 5], carbamoyl phosphate synthetase [Thoden99], malate dehydrogenase [Sanwal69, Spina70, Bologna07, Brown81], trehalose-6-phosphate synthase [Giaever88, Comment 6], UDP-N-acetyl-D-mannosamine dehydrogenase [Kawamura79], NADH:ubiquinone oxidoreductase (H+-transporting) [Euro09], fructose bisphosphate aldolase [Blom96], tryptophanase [Tokushige89, HogbergRaibaud75, Comment 7], glycerol dehydrogenase [Tang79, Comment 8], exopolyphosphatase [Akiyama93, Comment 9], guanylate kinase [Oeschger66], RNase BN exoribonuclease [Callahan00], thiamin kinase, RNase D exonuclease [Ghosh78], RNase R [Cheng02], dihydrofolate reductase [Wilquet98], acyl-CoA:diacylglycerol acyltransferase [Sorger02], 4-coumarate:CoA ligase [Gaid12], cinnamate:CoA ligase [Gaid12], thiobenzoate-S-methyltransferase [Zhao12], UDP-N-acetyl-α-D-glucosamine 6-dehydrogenase [Miller04], (E,E)-α-farnesene synthase [Green07], NADHX epimerase [Marbaix11], GA9 carboxyl methyltransferase [Varbanova07], phenylacetyl-coenzyme A:glycine N-acyltransferase [Nandi79], indole-3-acetate carboxyl methyltransferase [Zhao07a], acetone carboxylase [Sluis97], tetrahydropteroyl-γ-polyglutamate:L-glutamate γ-ligase (ADP-forming) [Shane80], phosphotransacetylase [Hartmanis84], diaminobutyrate aminotransferase [Comment 10], D-tagatose-6-phosphate kinase [Bissett80], N10-formyl-tetrahydrofolate:L-glutamate γ-ligase (ADP-forming) [Shane80], formyltransferase/hydrolase complex [Pomper01], carbamoyl-phosphate synthetase, arginine specific [Comment 11], trehalose-6-phosphate synthase [Lippert93], NADP+-benzaldehyde dehydrogenase [Stachow67], 5-enolpyruvoylshikimate-3-phosphate synthase [Comment 12], S-adenosylmethionine synthetase [Schroder97]

Enzymes inhibited by K+, sorted by the type of inhibition, are:

Inhibitor (Competitive) of: pyruvate decarboxylase [Lee85] Inhibitor (Mechanism unknown) of: guanosine-5'-triphosphate, 3'-diphosphate pyrophosphatase [Keasling93], dTMP kinase [Helmward89], aspartate semialdehyde dehydrogenase [Hegeman70, Helmward89], dihydrofolate reductase [Baccanari75], 6-phosphofructokinase [Baez13], ribonucleoside-triphosphate reductase [Eliasson92, Comment 13], propionyl-CoA carboxylase [Hardewig94], 3,7,4'-trimethylquercetagetin 6-O-methyltransferase [De85], 3,7-dimethylquercetagetin 6-O-methyltransferase [De85], 3,7,3'-methylquercetagetin 6-O-methyltransferase [De85], 4-oxalocrotonate tautomerase [Orii06], trehalase [Lee01a], porphobilinogen deaminase [Jones94a], γ-F420-2:α-L-glutamate ligase [Li03], L-lysine monooxygenase [Flashner74]

This compound has been characterized as a cofactor or prosthetic group of the following enzymes: methionine adenosyltransferase, rhamnulose-1-phosphate aldolase, ribokinase, UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase, inosine kinase, guanosine kinase, pyruvate kinase, pyruvate kinase, phosphoribosylformylglycinamide cyclo-ligase, pyridoxal kinase, folylpoly-γ-glutamate synthetase, pantothenate synthetase, selenide, water dikinase, tRNA nucleotidyltransferase, CTP:2,3,4-saturated L-phosphatidate cytidylyltransferase, 10-formyltetrahydrofolate:L-methionyl-tRNAfMet N-formyltransferase, D-malate dehydrogenase (decarboxylating), ribonucleoside-triphosphate reductase, ribonuclease, homoserine kinase, phosphoribosylformylglycinamidine cyclo-ligase, phosphoribosylglycinamidine synthetase, propanediol dehydratase, homoserine kinase, pyruvate kinase, pyruvate kinase, asparaginase, pyruvate kinase, methionine adenosyltransferase, pyruvate kinase, fructokinase, 3-methylaspartase, phosphotransacetylase, fructokinase, inosine kinase, guanosine kinase

This compound has been characterized as an alternative substrate of the following enzymes: L-proline:H+ symporter


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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