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MetaCyc Compound: 1-pyrroline-2-carboxylate

Synonyms: 1-pyrroline-2-carboxylic acid, Δ1-pyrroline-2-carboxylate

Chemical Formula: C5H6NO2

Molecular Weight: 112.11 Daltons

Monoisotopic Molecular Weight: 113.0476784741 Daltons

1-pyrroline-2-carboxylate compound structure

SMILES: C1(CCC(C([O-])=O)=N1)

InChI: InChI=1S/C5H7NO2/c7-5(8)4-2-1-3-6-4/h1-3H2,(H,7,8)/p-1

InChIKey: InChIKey=RHTAIKJZSXNELN-UHFFFAOYSA-M

Unification Links: ChEBI:17425 , ChemSpider:10140211 , HMDB:HMDB06875 , MetaboLights:MTBLC17425 , PubChem:11966218 , PubChem:21939120

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -11.095345 Inferred by computational analysis [Latendresse13]

Reactions known to consume the compound:

L-proline biosynthesis IV , trans-3-hydroxy-L-proline degradation :
L-proline + NAD(P)+1-pyrroline-2-carboxylate + NAD(P)H + 2 H+

Reactions known to produce the compound:

L-proline biosynthesis IV :
2-keto-ornithine → 1-pyrroline-2-carboxylate + H2O + H+

trans-3-hydroxy-L-proline degradation :
trans-3-hydroxy-L-proline → 1-pyrroline-2-carboxylate + H2O + H+

In Reactions of unknown directionality:

Not in pathways:
D-proline + an unknown oxidized electron acceptor = 1-pyrroline-2-carboxylate + an unknown reduced electron acceptor + H+
D-proline + an ubiquinone = 1-pyrroline-2-carboxylate + an ubiquinol + H+
L-proline + NADP+ = 1-pyrroline-2-carboxylate + NADPH + 2 H+

This compound has been characterized as an alternative substrate of the following enzymes: Δ1-piperideine-2-carboxylate reductase


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sun May 24, 2015, biocyc14.