MetaCyc Compound: p-aminobenzoyl glutamate

Synonyms: 4-aminobenzoyl-glutamate, pABA-Glu, N-(para-aminobenzoyl)-L-glutamate, N-(4-aminobenzoyl)-L-glutamic acid, N-(4-aminobenzoyl)-L-glutamate

Chemical Formula: C12H12N2O5

Molecular Weight: 264.24 Daltons

Monoisotopic Molecular Weight: 266.0902715703 Daltons

<i>p</i>-aminobenzoyl glutamate compound structure

SMILES: C([O-])(=O)CCC([NH]C(=O)C1(C=CC(=CC=1)N))C(=O)[O-]

InChI: InChI=1S/C12H14N2O5/c13-8-3-1-7(2-4-8)11(17)14-9(12(18)19)5-6-10(15)16/h1-4,9H,5-6,13H2,(H,14,17)(H,15,16)(H,18,19)/p-2


Unification Links: ChemSpider:4279300 , PubChem:5103842

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -33.964798 Inferred by computational analysis [Latendresse13]

Reactions known to consume the compound:

Not in pathways:
p-aminobenzoyl glutamate + H2O → 4-aminobenzoate + L-glutamate

Reactions known to produce the compound:

Not in pathways:
4-aminobenzoate + L-glutamate + ATP → p-aminobenzoyl glutamate + AMP + diphosphate + H+

In Transport reactions:
p-aminobenzoyl glutamate[periplasmic space] + H+[periplasmic space]p-aminobenzoyl glutamate[cytosol] + H+[cytosol]

Enzymes inhibited by p-aminobenzoyl glutamate, sorted by the type of inhibition, are:

Inhibitor (Competitive) of: dihydropteroate synthase [Richey71, Helmward89]


Helmward89: Helmward Z "Handbook of Enzyme Inhibitors. 2nd, revised and enlarged edition." Weinheim, Federal Republic of Germany ; New York, NY, USA , 1989.

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Richey71: Richey DP, Brown GM "Hydroxymethyldihydropteridine pyrophosphokinase and dihydropteroate synthetase from Escherichia coli." Methods in Enzymology 1971; 18B:765-771.

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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