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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Compound: p-aminobenzoyl glutamate

Synonyms: 4-aminobenzoyl-glutamate, pABA-Glu, N-(para-aminobenzoyl)-L-glutamate, N-(4-aminobenzoyl)-L-glutamic acid, N-(4-aminobenzoyl)-L-glutamate

Chemical Formula: C12H12N2O5

Molecular Weight: 264.24 Daltons

Monoisotopic Molecular Weight: 266.0902715703 Daltons

SMILES: C([O-])(=O)CCC([NH]C(=O)C1(C=CC(=CC=1)N))C(=O)[O-]

InChI: InChI=1S/C12H14N2O5/c13-8-3-1-7(2-4-8)11(17)14-9(12(18)19)5-6-10(15)16/h1-4,9H,5-6,13H2,(H,14,17)(H,15,16)(H,18,19)/p-2

InChIKey: InChIKey=GADGMZDHLQLZRI-UHFFFAOYSA-L

Unification Links: ChemSpider:4279300 , PubChem:5103842

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -33.964798 Inferred by computational analysis [Latendresse13]

Reactions known to consume the compound:

Not in pathways:
p-aminobenzoyl glutamate + H2O → 4-aminobenzoate + L-glutamate

Reactions known to produce the compound:

Not in pathways:
4-aminobenzoate + L-glutamate + ATP → p-aminobenzoyl glutamate + AMP + diphosphate + H+

In Transport reactions:
p-aminobenzoyl glutamate[periplasmic space] + H+[periplasmic space]p-aminobenzoyl glutamate[cytosol] + H+[cytosol]

Enzymes inhibited by p-aminobenzoyl glutamate, sorted by the type of inhibition, are:

Inhibitor (Competitive) of: dihydropteroate synthase [Richey71, Helmward89]


References

Helmward89: Helmward Z "Handbook of Enzyme Inhibitors. 2nd, revised and enlarged edition." Weinheim, Federal Republic of Germany ; New York, NY, USA , 1989.

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Richey71: Richey DP, Brown GM "Hydroxymethyldihydropteridine pyrophosphokinase and dihydropteroate synthetase from Escherichia coli." Methods in Enzymology 1971; 18B:765-771.


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Wed Dec 17, 2014, biocyc12.