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MetaCyc Compound: MoO2-molybdopterin cofactor

Synonyms: MoCo (dioxyo), molybdenum cofactor (dioxyo), MoO2(OH)Dtpp-mP, {[(5aR,8R,9aR)-2-amino-4-oxo-6,7-di(sulfanyl-κS)-1,5,5a,8,9a,10-hexahydro-4H-pyrano[3,2-g]pteridin-8-yl]methyl dihydrogenato(2-) phosphate}(dioxo)molybdate, MoO2-Mo-MPT

Superclasses: an organic heterocyclic compound an organic heterobicyclic compound a pteridine a pterin a Mo-molybdopterin cofactor
an organic heterocyclic compound an organonitrogen heterocyclic compound a pteridine a pterin a Mo-molybdopterin cofactor

Chemical Formula: C10H10N5O8PS2Mo

Molecular Weight: 519.25 Daltons

Monoisotopic Molecular Weight: 522.8918980779999 Daltons

SMILES: C(OP([O-])(=O)[O-])C2(C1(S[Mo](=O)(=O)SC=1[CH]3([CH](O2)NC4(=C(N3)C(=O)NC(N)=N4))))

InChI: InChI=1S/C10H14N5O6PS2.Mo.2O/c11-10-14-7-4(8(16)15-10)12-3-6(24)5(23)2(21-9(3)13-7)1-20-22(17,18)19;;;/h2-3,9,12,23-24H,1H2,(H2,17,18,19)(H4,11,13,14,15,16);;;/q;+2;;/p-4/t2-,3+,9-;;;/m1.../s1

InChIKey: InChIKey=HDAJUGGARUFROU-JSUDGWJLSA-J

Unification Links: ChEBI:71302 , PubChem:25202532

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -248.24603 Inferred by computational analysis [Latendresse, 2013]

Reactions known to consume the compound:

cytidylyl molybdenum cofactor biosynthesis :
MoO2-molybdopterin cofactor + CTP + H+ → cytidylyl molybdenum cofactor + diphosphate

guanylyl molybdenum cofactor biosynthesis :
MoO2-molybdopterin cofactor + GTP + H+ → guanylyl molybdenum cofactor + diphosphate

thio-molybdenum cofactor biosynthesis :
MoO2-molybdopterin cofactor + L-cysteine + 2 H+ → thio-molybdenum cofactor + L-alanine + H2O

Reactions known to produce the compound:

molybdenum cofactor biosynthesis :
molybdopterin adenine dinucleotide + molybdate + H+MoO2-molybdopterin cofactor + AMP + H2O

Enzymes inhibited by MoO2-molybdopterin cofactor, sorted by the type of inhibition, are:

Inhibitor (Mechanism unknown) of: citrate lyase [Comment 1]

This compound has been characterized as a cofactor or prosthetic group of the following enzymes: hypoxanthine hydroxylase , xanthine oxidase , hypoxanthine dehydrogenase , xanthine dehydrogenase , thiosulfate reductase , respiratory arsenate reductase , ethylbenzene dehydrogenase , aldehyde oxidase , xanthine:NAD+ oxidoreductase , xanthine dehydrogenase , nitrate reductase , nitrate reductase , nitrate reductase


References

Clark90: Clark DP (1990). "Molybdenum cofactor negative mutants of Escherichia coli use citrate anaerobically." FEMS Microbiol Lett 1990;55(3);245-9. PMID: 2182384

Latendresse, 2013: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Nov 22, 2014, biocyc13.