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MetaCyc Compound: Ag+

Synonyms: silver

Superclasses: an ion a cation

Component of: silver nitrate

Chemical Formula: Ag

Molecular Weight: 107.87 Daltons

Monoisotopic Molecular Weight: 107.9129180321 Daltons

SMILES: [Ag+]

InChI: InChI=1S/Ag/q+1

InChIKey: InChIKey=FOIXSVOLVBLSDH-UHFFFAOYSA-N

Unification Links: CAS:14701-21-4 , ChEBI:49468 , ChemSpider:94565 , HMDB:HMDB02659 , IAF1260:48910 , PubChem:104755

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -0.3120594 Inferred by computational analysis [Latendresse13]

In Transport reactions:
Ag+[cytosol] + ATP + H2O ↔ Ag+[extracellular space] + ADP + phosphate + H+ ,
Ag+[cytosol] + H+[periplasmic space]Ag+[extracellular space] + H+[cytosol]

Enzymes inhibited by Ag+, sorted by the type of inhibition, are:

Inhibitor (Mechanism unknown) of: NADPH-dependent curcumin reductase [Hassaninasab11] , glutaminase [Hartman68] , fumarase A [Xu12] , cellobiose 2-epimerase [Taguchi08] , luteolin glucuronide β-glucuronidase [Schulz87] , luteolin triglucuronide β-glucuronidase [Schulz87] , synephrine dehydratase [Manne86] , superoxide dismutase [Takenaka11] , 1,2,4-trihydroxybenzene 1,2-dioxygenase [Takenaka03] , 2-hydroxybiphenyl-3-monooxygenase [Suske97] , pesudooxynicotine oxidase [Qiu12] , nicotine dehydrogenase [Tang09a] , pseudoroxynicotine dehydrogenase [Tang09a] , N-cyclohexylformamide hydratase [Goda01] , N-benzylformamide deformylase [Fukatsu04] , 7-methylxanthine demethylase [Gluck88] , cholate 12α-hydroxy dehydrogenase [Braun91a] , 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase [Condemine84] , β-alanine amide amidase [Komeda04] , L-proline amide hydrolase [Komeda04a] , hydroxyproline 2-epimerase [Adams64] , Δ1-pyrroline-4-hydroxy-2-carboxylate deaminase [Singh65] , glycerol dehydratase [Schneider70] , NAD-dependent formate dehydrogenase [Asano88] , 1-sucrose:sucrose fructosyltransferase [Koops96] , rubredoxin NAD+ reductase [Petitdemange79] , streptomycin 6-kinase [Sugiyama83] , 4-oxalocrotonate decarboxylase [Takenaka00] , 2-aminomuconic 6-semialdehyde dehydrogenase [Takenaka00] , 2-aminophenol 1,6-dioxygenase [Takenaka97] , N-acetylneuraminate synthase [Komaki97] , porphobilinogen deaminase [Jones94] , L-carnitine dehydrogenase [Mori88] , (S)-tetrahydroprotoberberine oxidase [Amann88] , kynurenine formamidase [Brown86] , choline dehydrogenase [Nagasawa76] , kynurenine formamidase [Brown86] , sarcosine oxidase [Nishiya93] , N-carbamoylsarcosine amidohydrolase [Kim86] , arginine deiminase [Monstadt91] , D-carnitine dehydrogenase [Setyahadi97] , nicotinate dehydrogenase [Hurh94] , putrescine N-methyltransferase [Mizusaki71] , α-D-galactosyl-(1-3)-1D-myo-inositol:raffinose galactosyltransferase [Gaudreault81]

Inhibitor (Other types) of: xylan 1,3-β-xylosidase [Umemoto08] , trans-permethrin hydrolase [Wu06a] , chitin disaccharide deacetylase [Ohishi97] , 3-hydroxyisobutyrate dehydrogenase [Chowdhury96] , nitrilase [Nagasawa90] , L-allo-threonine aldolase [Kataoka97] , raffinose synthase [Lehle73]


References

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Amann88: Amann M, Nagakura N, Zenk MH "Purification and properties of (S)-tetrahydroprotoberberine oxidase from suspension-cultured cells of Berberis wilsoniae." Eur. J. Biochem., 1988, 175:17-25.

Asano88: Asano Y, Sekigawa T, Inukai H, Nakazawa A (1988). "Purification and properties of formate dehydrogenase from Moraxella sp. strain C-1." J Bacteriol 170(7);3189-93. PMID: 3384805

Braun91a: Braun M, Lunsdorf H, Buckmann AF (1991). "12 alpha-hydroxysteroid dehydrogenase from Clostridium group P, strain C 48-50. Production, purification and characterization." Eur J Biochem 196(2);439-50. PMID: 2007406

Brown86: Brown D, Hitchcock MJ, Katz E (1986). "Purification and characterization of kynurenine formamidase activities from Streptomyces parvulus." Can J Microbiol 32(6);465-72. PMID: 2425918

Chowdhury96: Chowdhury EK, Nagata S, Misono H (1996). "3-Hydroxyisobutyrate dehydrogenase from Pseudomonas putida E23: purification and characterization." Biosci Biotechnol Biochem 60(12);2043-7. PMID: 8988636

Condemine84: Condemine G, Hugouvieux-Cotte-Pattat N, Robert-Baudouy J (1984). "An enzyme in the pectinolytic pathway of Erwinia chrysanthemi: 2-keto-3-deoxygluconate oxidoreductase." Journal of General Microbiology 130, 2839-2844.

Fukatsu04: Fukatsu H, Hashimoto Y, Goda M, Higashibata H, Kobayashi M (2004). "Amine-synthesizing enzyme N-substituted formamide deformylase: screening, purification, characterization, and gene cloning." Proc Natl Acad Sci U S A 101(38);13726-31. PMID: 15358859

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Goda01: Goda M, Hashimoto Y, Shimizu S, Kobayashi M (2001). "Discovery of a novel enzyme, isonitrile hydratase, involved in nitrogen-carbon triple bond cleavage." J Biol Chem 276(26);23480-5. PMID: 11306561

Hartman68: Hartman SC (1968). "Glutaminase of Escherichia coli. I. Purification and general catalytic properties." J Biol Chem 1968;243(5);853-63. PMID: 4966660

Hassaninasab11: Hassaninasab A, Hashimoto Y, Tomita-Yokotani K, Kobayashi M (2011). "Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism." Proc Natl Acad Sci U S A 108(16);6615-20. PMID: 21467222

Hurh94: Hurh B, Yamane T, Nagasawa T (1994). "Purification and characterization of nicotinic acid dehydrogenase from Pseudomonas fluorescens TN5." J. Ferment. Bioeng. 78, No. 1, 19-26.

Jones94: Jones RM, Jordan PM (1994). "Purification and properties of porphobilinogen deaminase from Arabidopsis thaliana." Biochem J 299 ( Pt 3);895-902. PMID: 8192681

Kataoka97: Kataoka M, Wada M, Nishi K, Yamada H, Shimizu S (1997). "Purification and characterization of L-allo-threonine aldolase from Aeromonas jandaei DK-39." FEMS Microbiol Lett 151(2);245-8. PMID: 9228760

Kim86: Kim JM, Shimizu S, Yamada H (1986). "Purification and characterization of a novel enzyme, N-carbamoylsarcosine amidohydrolase, from Pseudomonas putida 77." J Biol Chem 261(25);11832-9. PMID: 3745168

Komaki97: Komaki E, Ohta Y, Tsukada Y (1997). "Purification and characterization of N-acetylneuraminate synthase from Escherichia coli K1-M12." Biosci Biotechnol Biochem 61(12);2046-50. PMID: 9438985

Komeda04: Komeda H, Harada H, Washika S, Sakamoto T, Ueda M, Asano Y (2004). "A novel R-stereoselective amidase from Pseudomonas sp. MCI3434 acting on piperazine-2-tert-butylcarboxamide." Eur J Biochem 271(8);1580-90. PMID: 15066183

Komeda04a: Komeda H, Harada H, Washika S, Sakamoto T, Ueda M, Asano Y (2004). "S-stereoselective piperazine-2-tert-butylcarboxamide hydrolase from Pseudomonas azotoformans IAM 1603 is a novel L-amino acid amidase." Eur J Biochem 271(8);1465-75. PMID: 15066172

Koops96: Koops AJ, Jonker HH (1996). "Purification and Characterization of the Enzymes of Fructan Biosynthesis in Tubers of Helianthus tuberosus Colombia (II. Purification of Sucrose:Sucrose 1-Fructosyltransferase and Reconstitution of Fructan Synthesis in Vitro with Purified Sucrose:Sucrose 1-Fructosyltransferase and Fructan:Fructan 1-Fructosyltransferase)." Plant Physiol 1996;110(4);1167-1175. PMID: 12226250

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Lehle73: Lehle L, Tanner W (1973). "The function of myo-inositol in the biosynthesis of raffinose. Purification and characterization of galactinol:sucrose 6-galactosyltransferase from Vicia faba seeds." Eur J Biochem 38(1);103-10. PMID: 4774118

Manne86: Manne V, Kutty KR, Pillarisetti SR (1986). "Purification and properties of synephrinase from Arthrobacter synephrinum." Arch Biochem Biophys 248(1);324-34. PMID: 3729420

Mizusaki71: Mizusaki, Shigenobu, Tanabe, Yoko, Noguchi, Masao, Tamaki, Einosuke (1971). "Phytochemical studies on tobacco alkaloids XIV. The occurrence and properties of putrescine N-methyltransferase in tobacco roots." Plant and Cell Physiology, 12:633-640.

Monstadt91: Monstadt GM, Holldorf AW (1991). "Arginine deiminase from Halobacterium salinarium. Purification and properties." Biochem J 1991;273 ( Pt 3);739-45. PMID: 1847623

Mori88: Mori, N., Kasugai, T., Kitamato, Y., Ichikawa, Y. (1988). "Purification and some properties of carnitine dehydrogenase from Xanthomonas translucens." Agric. Biol. Chem. 52, 249-250.

Nagasawa76: Nagasawa, T., Mori, N., Tani, Y., Ogata, K. (1976). "Characterization of choline dehydrogenase from Pseudomonas aeruginosa A-16." Agr. Biol. Chem. 40(10):2077-2084.

Nagasawa90: Nagasawa T, Mauger J, Yamada H (1990). "A novel nitrilase, arylacetonitrilase, of Alcaligenes faecalis JM3. Purification and characterization." Eur J Biochem 194(3);765-72. PMID: 2269298

Nishiya93: Nishiya, Y., Imanaka, T. (1993). "Cloning and sequencing of the sarcosine oxidase gene from Arthrobacter sp. TE1826." J. Ferment. bioeng. 75 (4):239-244.

Ohishi97: Ohishi, K., Yamagishi, M., Ohta, T., Motosugi, M., Izumida,H., Sano, H., Adachi, K., Miwa, T. (1997). "Purification and properties of two deacetylases produced by Vibrio alginolyticus H-8." Bioscience, biotechnology, and biochemistry 61(7):1113-1117.

Petitdemange79: Petitdemange H, Marczak R, Blusson H, Gay R (1979). "Isolation and properties of reduced nicotinamide adenine dinucleotiderubredoxin oxidoreductase of Clostridium acetobutylicum." Biochem Biophys Res Commun 1979;91(4);1258-65. PMID: 526302

Qiu12: Qiu J, Ma Y, Wen Y, Chen L, Wu L, Liu W (2012). "Functional Identification of Two Novel Genes from Pseudomonas sp. Strain HZN6 Involved in the Catabolism of Nicotine." Appl Environ Microbiol. PMID: 22267672

Schneider70: Schneider Z, Larsen EG, Jacobson G, Johnson BC, Pawelkiewicz J (1970). "Purification and properties of glycerol dehydrase." J Biol Chem 245(13);3388-96. PMID: 4989992

Schulz87: Schulz M, Weissenbock G (1987). "Partial purification and characterization of a luteolin-triglucuronide-specific β-glucuronidase from rye primary leaves (Secale cereale)." Phytochemistry 26(4):933-937.

Setyahadi97: Setyahadi S, Ueyama T, Arimoto T, Mori N, Kitamoto Y (1997). "Purification and properties of a new enzyme, D-carnitine dehydrogenase, from Agrobacterium sp. 525a." Biosci Biotechnol Biochem 61(6);1055-8. PMID: 9214773

Singh65: Singh RM, Adams E (1965). "Enzymatic deamination of delta-1-pyrroline-4-hydroxy-2-carboxylate to 2,5-dioxovalerate (alpha-ketoglutaric semialdehyde)." J Biol Chem 240(11);4344-51. PMID: 5845838

Sugiyama83: Sugiyama M, Sakamoto M, Mochizuki H, Nimi O, Nomi R (1983). "Purification and characterization of streptomycin 6-kinase, an enzyme implicated in self-protection of a streptomycin-producing micro-organism." J Gen Microbiol 129(6);1683-7. PMID: 6313852

Suske97: Suske WA, Held M, Schmid A, Fleischmann T, Wubbolts MG, Kohler HP (1997). "Purification and characterization of 2-hydroxybiphenyl 3-monooxygenase, a novel NADH-dependent, FAD-containing aromatic hydroxylase from Pseudomonas azelaica HBP1." J Biol Chem 272(39);24257-65. PMID: 9305879

Taguchi08: Taguchi H, Hamada S, Kawauchi S, Ito H, Senoura T, Watanabe J, Nishimukai M, Ito S, Matsui H (2008). "Enzymatic properties of cellobiose 2-epimerase from Ruminococcus albus and the synthesis of rare oligosaccharides by the enzyme." Appl Microbiol Biotechnol 79(3);433-41. PMID: 18392616

Takenaka00: Takenaka S, Murakami S, Kim YJ, Aoki K (2000). "Complete nucleotide sequence and functional analysis of the genes for 2-aminophenol metabolism from Pseudomonas sp. AP-3." Arch Microbiol 174(4);265-72. PMID: 11081795

Takenaka03: Takenaka S, Okugawa S, Kadowaki M, Murakami S, Aoki K (2003). "The metabolic pathway of 4-aminophenol in Burkholderia sp. strain AK-5 differs from that of aniline and aniline with C-4 substituents." Appl Environ Microbiol 69(9);5410-3. PMID: 12957929

Takenaka11: Takenaka S, Koshiya J, Okugawa S, Takata A, Murakami S, Aoki K (2011). "Fe-superoxide dismutase and 2-hydroxy-1,4-benzoquinone reductase preclude the auto-oxidation step in 4-aminophenol metabolism by Burkholderia sp. strain AK-5." Biodegradation 22(1);1-11. PMID: 20480210

Takenaka97: Takenaka S, Murakami S, Shinke R, Hatakeyama K, Yukawa H, Aoki K (1997). "Novel genes encoding 2-aminophenol 1,6-dioxygenase from Pseudomonas species AP-3 growing on 2-aminophenol and catalytic properties of the purified enzyme." J Biol Chem 272(23);14727-32. PMID: 9169437

Tang09a: Tang H, Wang L, Meng X, Ma L, Wang S, He X, Wu G, Xu P (2009). "Novel nicotine oxidoreductase-encoding gene involved in nicotine degradation by Pseudomonas putida strain S16." Appl Environ Microbiol 75(3);772-8. PMID: 19060159

Umemoto08: Umemoto Y, Onishi R, Araki T (2008). "Cloning of a novel gene encoding beta-1,3-xylosidase from a marine bacterium, Vibrio sp. strain XY-214, and characterization of the gene product." Appl Environ Microbiol 74(1);305-8. PMID: 17993567

Wu06a: Wu PC, Liu YH, Wang ZY, Zhang XY, Li H, Liang WQ, Luo N, Hu JM, Lu JQ, Luan TG, Cao LX (2006). "Molecular cloning, purification, and biochemical characterization of a novel pyrethroid-hydrolyzing esterase from Klebsiella sp. strain ZD112." J Agric Food Chem 54(3);836-42. PMID: 16448191

Xu12: Xu FF, Imlay JA (2012). "Silver(I), mercury(II), cadmium(II), and zinc(II) target exposed enzymic iron-sulfur clusters when they toxify Escherichia coli." Appl Environ Microbiol 78(10);3614-21. PMID: 22344668


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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