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MetaCyc Compound: 2-aminomuconate 6-semialdehyde

Synonyms: 2-aminomuconate semialdehyde, 2-aminomuconic semialdehyde, 2-aminomuconic 6-semialdehyde, (2E,4Z)-2-amino-6-oxohexa-2,4-dienoate

Chemical Formula: C6H6NO3

Molecular Weight: 140.12 Daltons

Monoisotopic Molecular Weight: 141.0425930962 Daltons

2-aminomuconate 6-semialdehyde compound structure

SMILES: C(C=C(C([O-])=O)N)=CC=O

InChI: InChI=1S/C6H7NO3/c7-5(6(9)10)3-1-2-4-8/h1-4H,7H2,(H,9,10)/p-1/b2-1-,5-3+

InChIKey: InChIKey=QCGTZPZKJPTAEP-REDYYMJGSA-M

Unification Links: ChEBI:57495 , ChemSpider:7822225 , HMDB:HMDB01280 , KEGG:C03824 , MetaboLights:MTBLC57495 , PubChem:9543252

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -3.9653397 Inferred by computational analysis [Latendresse13]

Reactions known to consume the compound:

2-amino-3-carboxymuconate semialdehyde degradation to 2-oxopentenoate , 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA , 2-aminophenol degradation , 2-nitrobenzoate degradation I :
2-aminomuconate 6-semialdehyde + NAD+ + H2O → 2-aminomuconate + NADH + 2 H+

L-tryptophan degradation XI (mammalian, via kynurenine) :
2-aminomuconate 6-semialdehyde → picolinate + H2O

Reactions known to produce the compound:

2-amino-3-carboxymuconate semialdehyde degradation to 2-oxopentenoate , 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA , 2-nitrobenzoate degradation I :
aminocarboxymuconate semialdehyde + H+2-aminomuconate 6-semialdehyde + CO2

2-aminophenol degradation :
2-aminophenol + oxygen → 2-aminomuconate 6-semialdehyde + H+

This compound has been characterized as an alternative substrate of the following enzymes: 2-amino-5-methyl-muconate semialdehyde dehydrogenase


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Mon May 4, 2015, biocyc14.