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MetaCyc Gene-Ontology-Terms Class: GO:0016853 - isomerase activity

Definition: Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.

Note that enzymes of class EC:5.99.-.- should also be annotated to this term.

Parent Classes:
GO:0003824 - catalytic activity

Child Classes:
GO:0003916 - DNA topoisomerase activity (4),
GO:0008719 - dihydroneopterin triphosphate 2'-epimerase activity (1),
GO:0016854 - racemase and epimerase activity (27),
GO:0016859 - cis-trans isomerase activity (8),
GO:0016860 - intramolecular oxidoreductase activity (38),
GO:0016866 - intramolecular transferase activity (43),
GO:0016872 - intramolecular lyase activity (1),
GO:0051075 - S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity (1),
GO:0061593 - sulfoquinovose isomerase activity (1)

Term Members:
dihydroneopterin triphosphate 2'-epimerase monomer (folX),
phosphoglucosamine mutase (glmM),
L-rhamnose mutarotase,
L-arabinose isomerase monomer (araA),
L-ribulose 5-phosphate 4-epimerase monomer (araD),
L-ribulose-5-phosphate 4-epimerase (sgbE),
L-ribulose 5-phosphate 4-epimerase (ulaF),
D-glucuronate isomerase / D-galacturonate isomerase (uxaC),
indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase (trpC),
L-rhamnose isomerase (rhaA),
L-xylulose 5-phosphate 3-epimerase (ulaE),
mannose-6-phosphate isomerase (manA),
L-fucose mutarotase (fucU),
allulose-6-phosphate 3-epimerase (alsE),
phosphopentomutase (deoB),
phosphoglucomutase (pgm),
ribose pyranase (rbsD),
glutamate racemase (murI),
L-Ala-D/L-Glu epimerase (ycjG),
isopentenyl diphosphate isomerase (idi),
isochorismate synthase 1 (entC),
alanine racemase 1, PLP-binding, biosynthetic subunit (alr),
2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmM),
triosephosphate isomerase monomer (tpiA),
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase monomer (gpmA),
S-adenosylmethionine:tRNA ribosyltransferase-isomerase (queA),
ribulose-5-phosphate 3-epimerase (rpe),
allose-6-phosphate isomerase / ribose-5-phosphate isomerase B monomer (rpiB),
ribose-5-phosphate isomerase A (rpiA),
glutamate-1-semialdehyde aminotransferase (hemL),
UDP-galactopyranose mutase (glf),
N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'-phosphoribosyl)-4-imidazolecarboxamide isomerase (hisA),
UDP-N-acetylglucosamine 2-epimerase (wecB),
UDP-glucose 4-epimerase monomer (galE),
D-arabinose 5-phosphate isomerase (kdsD),
D-arabinose 5-phosphate isomerase (gutQ),
ADP-L-glycero-D-mannoheptose-6-epimerase (rfaD),
D-sedoheptulose 7-phosphate isomerase (lpcA),
FadJ monomer,
phosphomannomutase (cpsG),
galactose-1-epimerase (galM),
23S rRNA pseudouridine synthase (rluC),
tRNA pseudouridine synthase I (truA),
tRNA pseudouridine 13 synthase (truD),
predicted 5-keto 4-deoxyuronate isomerase monomer (kduI),
lysine 2,3-aminomutase (epmB),
sulfoquinovose isomerase (yihS),
23S rRNA pseudouridine 2457 synthase (rluE),
β-phosphoglucomutase (ycjU),
23S rRNA pseudouridine synthase (rluD),
tRNA pseudouridine 65 synthase (truC),
dTDP-4-dehydrorhamnose 3,5-epimerase (rfbC),
NAD(P)HX epimerase / NAD(P)HX dehydratase (yjeF),
16S rRNA pseudouridine 516 synthase (rsuA),
N-acetylneuraminate mutarotase (nanM),
23S rRNA pseudouridine 2605 synthase (rluB),
DNA gyrase, subunit B (gyrB),
DNA gyrase, subunit A,
dodecenoyl-CoA δ-isomerase, enoyl-CoA hydratase, 3-hydroxybutyryl-CoA epimerase, 3-hydroxyacyl-CoA dehydrogenase (fadB),
fumarase A monomer,
tRNA pseudouridine 55 synthase (truB),
23S rRNA and tRNA pseudouridine synthase (rluA),
dihydroneopterin aldolase (folB),
phospho-AI-2 isomerase (lsrG),
23S rRNA pseudouridine 2604 synthase (rluF),
DNA topoisomerase I (topA),
DNA topoisomerase III (topB),
peptidyl-prolyl cis-trans isomerase A (rotamase A) (ppiA),
FKBP-type peptidyl prolyl cis-trans isomerase (slyD),
FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase) (fklB),
peptidyl-prolyl cis-trans isomerase B (rotamase B) (ppiB),
peptidyl-prolyl cis-trans isomerase C (rotamase C) (ppiC),
peptidyl-prolyl cis-trans isomerase (fkpB),
peptidyl-prolyl cis-trans isomerase (PPIase) (surA),
chaperone protein Tig; trigger factor,
3,2-trans-enoyl-CoA isomerase 2 (PECI),
Maleylacetoacetate isomerase (GSTZ1),
Methylmalonyl-CoA mutase, mitochondrial,
phosphoglucomutase-1 (PGM1),
thromboxane-A synthase (TBXAS1),
hematopoietic prostaglandin D synthase (HPGDS),
prostaglandin-D2 synthase (PTGDS),
prostacyclin synthase (PTGIS),
Triosephosphate isomerase (TPI1),
phosphoglycerate mutase 2 (PGAM2),
Bisphosphoglycerate mutase (BPGM),
scyllo-inosose epimerase/isomerase (iolI),
5-deoxy-D-glucuronate isomerase (iolB),
phosphoglycerate mutase 1 (PGAM1),
glucose-6-phosphate isomerase (GPI),
peroxisomal bifunctional enzyme (EHHADH),
α-methylacyl-CoA racemase (AMACR),
3 β-hydroxysteroid dehydrogenase/ Δ 5-->4-isomerase type 1 (HSD3B1),
Steroid Delta-isomerase (HSD3B2)

Unification Links: GO:0016853

Relationship Links: ENZYME:RELATED-TO:5

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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