MetaCyc Gene-Ontology-Terms Class: GO:0006783 - heme biosynthetic process

Synonyms: haem biosynthesis, haem biosynthetic process, heme anabolism, heme biosynthesis, heme formation, heme synthesis

Definition: The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.

Parent Classes:
GO:0006779 - porphyrin-containing compound biosynthetic process ,
GO:0042168 - heme metabolic process ,
GO:0046148 - pigment biosynthetic process

Child Classes:
GO:0019354 - siroheme biosynthetic process (1) ,
GO:0048034 - heme O biosynthetic process (1)

GO:0006782 - protoporphyrinogen IX biosynthetic process (9)

Term Members:
hydroxymethylbilane synthase (hemC) ,
porphobilinogen synthase (hemB) ,
uroporphyrinogen decarboxylase (hemE) ,
ferrochelatase (hemH) ,
coproporphyrinogen III oxidase (hemF) ,
HemG ,
heme O synthase (cyoE) ,
2-amino-3-ketobutyrate coenzyme A ligase (GCAT) ,
Ferrochelatase, mitochondrial (FECH) ,
Protoporphyrinogen oxidase (PPOX) ,
Coproporphyrinogen-III oxidase, mitochondrial (CPOX) ,
Uroporphyrinogen decarboxylase (UROD) ,
uroporphyrinogen-III synthase (UROS) ,
porphobilinogen deaminase (HMBS) ,
Delta-aminolevulinic acid dehydratase (ALAD) ,
5-aminolevulinate synthase, nonspecific, mitochondrial (ALAS1) ,
5-aminolevulinate synthase, erythroid-specific, mitochondrial (ALAS2)

Unification Links: GO:0006783

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Mon Oct 5, 2015, biocyc12.