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MetaCyc Gene-Ontology-Terms Class: GO:0006783 - heme biosynthetic process

Synonyms: haem biosynthesis, haem biosynthetic process, heme anabolism, heme biosynthesis, heme formation, heme synthesis

Definition: The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.

Parent Classes:
GO:0006779 - porphyrin-containing compound biosynthetic process,
GO:0042168 - heme metabolic process,
GO:0046148 - pigment biosynthetic process

Child Classes:
GO:0019354 - siroheme biosynthetic process (1),
GO:0048034 - heme O biosynthetic process (1)

GO:0006782 - protoporphyrinogen IX biosynthetic process (9)

Term Members:
uroporphyrinogen decarboxylase (hemE),
ferrochelatase (hemH),
coproporphyrinogen III oxidase (hemF),
hydroxymethylbilane synthase (hemC),
porphobilinogen synthase (hemB),
heme O synthase (cyoE),
2-amino-3-ketobutyrate coenzyme A ligase (GCAT),
Ferrochelatase, mitochondrial (FECH),
Protoporphyrinogen oxidase (PPOX),
Coproporphyrinogen-III oxidase, mitochondrial (CPOX),
Uroporphyrinogen decarboxylase (UROD),
uroporphyrinogen-III synthase (UROS),
porphobilinogen deaminase (HMBS),
Delta-aminolevulinic acid dehydratase (ALAD),
5-aminolevulinate synthase, nonspecific, mitochondrial (ALAS1),
5-aminolevulinate synthase, erythroid-specific, mitochondrial (ALAS2)

Unification Links: GO:0006783

Relationship Links: MetaCyc:RELATED-TO:HEMESYN2-PWY, Reactome:RELATED-TO:REACT_9465, Reactome:RELATED-TO:REACT_31279, Reactome:RELATED-TO:REACT_32048, Reactome:RELATED-TO:REACT_33762, Reactome:RELATED-TO:REACT_34363, Reactome:RELATED-TO:REACT_77747, Reactome:RELATED-TO:REACT_78621, Reactome:RELATED-TO:REACT_81550, Reactome:RELATED-TO:REACT_83388, Reactome:RELATED-TO:REACT_83502, Reactome:RELATED-TO:REACT_84579, Reactome:RELATED-TO:REACT_88226, Reactome:RELATED-TO:REACT_88314, Reactome:RELATED-TO:REACT_96583, Reactome:RELATED-TO:REACT_96932, Reactome:RELATED-TO:REACT_98337, Reactome:RELATED-TO:REACT_98999, Reactome:RELATED-TO:REACT_99419, Reactome:RELATED-TO:REACT_103117, Reactome:RELATED-TO:REACT_108806, Reactome:RELATED-TO:REACT_115611

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Sun May 1, 2016, biocyc14.