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MetaCyc Gene-Ontology-Terms Class: GO:0005887 - integral component of plasma membrane

Definition: The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

Parent Classes:
GO:0016021 - integral component of membrane,
GO:0031226 - intrinsic component of plasma membrane

Child Classes:
GO:0071575 - integral component of external side of plasma membrane (8)

Term Members:
protein disulfide oxidoreductase - DsbDreduced,
penicillin-binding protein 6 (dacC),
prolipoprotein signal peptidase II (lspA),
cell shape; peptidoglycan synthetase; penicillin-binding protein 2 (mrdA),
DD-carboxypeptidase, penicillin-binding protein 6b (dacD),
phosphatidylglycerol-prolipoprotein diacylglyceryl transferase (lgt),
Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein (wzzE),
essential cell division protein FtsI; penicillin-binding protein 3,
predicted Wzy protein involved in ECA polysaccharide chain elongation (wzyE),
fructose PTS permease - FruA subunit,
predicted PTS permease - SgcC subunit,
predicted PTS permease - FrwC subunit,
peptidoglycan glycosyltransferase (pbpC),
essential cell division protein FtsN,
MrcB,
MrcA,
1,4-dihydroxy-2-naphthoate octaprenyltransferase (menA),
GlpD,
glycerol-3-phosphate acyltransferase (plsB),
phosphatidylglycerophosphatase A (pgpA),
phosphatidylglycerophosphatase C (pgpC),
phosphatidylglycerophosphate synthase (pgsA),
inner membrane protein with thiosulfate sulfurtransferase activity (ygaP),
formate dehydrogenase N, γ subunit (fdnI),
formate dehydrogenase-O, γ subunit (fdoI),
dimethyl sulfoxide reductase, chain C (dmsC),
fumarate reductase,
fumarate reductase membrane protein (frdD),
hydrogenase 2 - integral membrane subunit HybB,
hydrogenase 2 - [Fe-S] binding, ferredoxin-type component HybA,
cytochrome bo terminal oxidase,
cytochrome bo terminal oxidase subunit III (cyoC),
cytochrome bo terminal oxidase subunit I (cyoB),
cytochrome bo terminal oxidase subunit II (cyoA),
cytochrome bo terminal oxidase subunit IV (cyoD),
cytochrome bd-I terminal oxidase,
cytochrome bd-I terminal oxidase - CydX subunit,
cytochrome bd-I terminal oxidase subunit II (cydB),
cytochrome bd-I terminal oxidase subunit I (cydA),
trimethylamine N-oxide reductase, c-type cytochrome subunit (torY),
NADH:ubiquinone oxidoreductase, membrane subunit N (nuoN),
NADH:ubiquinone oxidoreductase, membrane subunit M (nuoM),
NADH:ubiquinone oxidoreductase, membrane subunit L (nuoL),
NADH:ubiquinone oxidoreductase, membrane subunit K (nuoK),
NADH:ubiquinone oxidoreductase, membrane subunit J (nuoJ),
NADH:ubiquinone oxidoreductase, membrane subunit H (nuoH),
NADH:ubiquinone oxidoreductase, membrane subunit A (nuoA),
D-lactate dehydrogenase (dld),
pyridine nucleotide transhydrogenase,
pyridine nucleotide transhydrogenase, α subunit (pntA),
pyridine nucleotide transhydrogenase, β subunit (pntB),
lauroyl acyltransferase (lpxL),
palmitoleoyl acyltransferase (lpxP),
myristoyl-acyl carrier protein (ACP)-dependent acyltransferase (lpxM),
Rfe,
D-alanyl-D-alanine carboxypeptidase, fraction A; penicillin-binding protein 5 (dacA),
undecaprenyl pyrophosphate phosphatase (bacA),
phosphatidylglycerophosphatase [multifunctional] (pgpB),
Kdo2-lipid A phosphotransferase (lpxT),
protein-tyrosine kinase (wzc),
endolytic murein transglycosylase (mltG),
hydrogenase 1, b-type cytochrome subunit (hyaC),
formate-dependent nitrite reductase, 4Fe-4S subunit (nrfC),
formate dependent nitrite reductase - NrfD subunit,
intramembrane serine protease GlpG,
apolipoprotein N-acyltransferase (lnt),
leader peptidase (signal peptidase I) (lepB),
HflK-HflC complex; regulator of FtsH protease,
nitrate reductase A, γ subunit (narI),
hydrogenase 3,
hydrogenase 3, membrane subunit (hycD),
penicillin-binding protein 7 (pbpG),
murein DD-endopeptidase MepM,
phosphopantetheinyl transferase (entD),
protease IV (sppA),
phosphoethanolamine transferase (opgE),
membrane-bound lytic murein exotransglycosylase A (mltA),
NADH:quinone oxidoreductase II (ndh),
quinol dehydrogenase (msrQ),
poly-β-1,6-N-acetyl-D-glucosamine synthase,
poly-β-1,6-N-acetyl-D-glucosamine synthase - PgaC subunit,
poly-β-1,6-N-acetyl-D-glucosamine synthase - PgaD subunit,
MalX PTS permease,
glucose PTS permease - PtsG subunit,
N-acetylmuramic acid PTS permease / anhydro-N-acetylmuramic acid permease (murP),
predicted PTS permease - CmtA subunit,
MtlA,
sorbitol PTS permease - SrlE subunit,
sorbitol PTS permease - SrlA subunit,
trehalose PTS permease - TreB subunit,
2-O-α-mannosyl-D-glycerate PTS permease (mngA),
chitobiose PTS permease - ChbC subunit,
galactitol PTS permease - GatC subunit,
NagE,
mannose PTS permease - ManX subunit,
mannose PTS permease - ManY subunit,
mannose PTS permease - ManZ subunit,
L-ascorbate PTS permease - UlaA subunit,
L-arginine ABC transporter - membrane subunit (artM),
L-arginine ABC transporter - membrane subunit (artQ),
ABC complex for formation and release of holoCcmE - membrane subunit CcmC,
ABC complex for formation and release of holoCcmE - membrane subunit CcmB,
ABC complex for formation and release of holoCcmE - membrane subunit CcmD,
aliphatic sulfonate ABC transporter - membrane subunit (ssuC),
zinc, cadmium and lead efflux system (zntA),
glutathione ABC transporter - membrane subunit (gsiC),
glutathione ABC transporter - membrane subunit (gsiD),
K+ transporting ATPase - KdpC subunit,
K+ transporting ATPase - ATP binding subunit (kdpB),
K+ transporting ATPase - K+ channel forming subunit (kdpA),
Cu+ efflux ATPase (copA),
nickel ABC transporter - membrane subunit (nikC),
nickel ABC transporter - membrane subunit (nikB),
dipeptide ABC transporter - putative membrane subunit (dppC),
dipeptide ABC transporter - putative membrane subunit (dppB),
ferric enterobactin ABC transporter - membrane subunit (fepG),
ferric enterobactin ABC transporter - membrane subunit (fepD),
glycerol-3-phosphate / glycerophosphodiester ABC transporter,
glycerol-3-phosphate ABC transporter - membrane subunit (ugpE),
glycerol-3-phosphate ABC transporter - membrane subunit (ugpA),
glutathione / L-cysteine efflux transporter CydDC,
glutathione / L-cysteine efflux transporter - CydC subunit,
glutathione / L-cysteine efflux transporter - CydD subunit,
murein tripeptide ABC transporter / peptide ABC transporter - putative membrane subunit (oppC),
murein tripeptide ABC transporter / peptide ABC transporter - putative membrane subunit (oppB),
ATP synthase F0 complex - a subunit (atpB),
phosphate ABC transporter - membrane subunit (pstC),
phosphate ABC transporter - membrane subunit (pstA),
cystine/cysteine ABC transporter - predicted membrane subunit (tcyL),
maltose ABC transporter - membrane subunit (malG),
maltose ABC transporter - membrane subunit (malF),
vitamin B12 ABC transporter,
vitamin B12 ABC transporter - membrane subunit (btuC),
arabinose:H+ symporter (araE),
fucose:H+ symporter (fucP),
α-ketoglutarate:H+ symporter (kgtP),
K+ : H+ antiporter KefB,
KefC,
uracil:H+ symporter UraA,
uracil:H+ symporter RutG,
lysine:H+ symporter (lysP),
twin arginine protein translocation system - TatA protein,
twin arginine protein translocation system - TatE protein,
twin arginine protein translocation system - TatC protein,
twin arginine protein translocation system - TatB protein,
aromatic amino acid exporter (yddG),
gluconate transporter GntU,
gluconate transporter GntT,
gluconate / fructuronate transporter GntP,
xanthine:H+ symporter XanP,
xanthine:H+ symporter XanQ,
glutamic acid:4-aminobutyrate antiporter (gadC),
K+ transporter TrkG,
K+ transporter TrkH,
serine:H+ symporter SdaC,
adenine:H+ symporter (adeP),
O-Acetylserine / cysteine export protein (eamB),
AdiC monomer,
Na+ / K+:H+ antiporter ChaA,
multidrug efflux transporter MdfA (multifunctional),
multidrug efflux transporter / bile salt:H+ antiporter / Na+:H+ antiporter / K+:H+ antiporter (mdtM),
nitrate / nitrite transporter NarU,
ClcA,
cytosine transporter (codB),
4-aminobutyrate:H+ symporter (gabP),
ArsB monomer,
nucleoside:H+ symporter NupG,
acetate / succinate:H+ symporter (satP),
urate:H+ symporter (uacT),
ProP,
putrescine:H+ symporter PuuP,
putrescine:H+ symporter PlaP,
dipeptide / tripeptide:H+ symporter DtpB,
dipeptide / tripeptide:H+ symporter DptC (dtpC),
dipeptide:H+ symporter DtpD,
tripeptide / dipeptide:H+ symporter DtpA,
hexose-6-phosphate:phosphate antiporter (uhpT),
galactose:H+ symporter (galP),
hexuronate transporter (exuT),
shikimate:H+ symporter (shiA),
tryptophan:H+ symporter TnaB,
L-idonate / 5-ketogluconate / gluconate transporter IdnT,
lactose / melibiose:H+ symporter LacY,
glycolate / lactate:H+ symporter (glcA),
metal phosphate:H+ symporter PitB,
phenylalanine:H+ symporter PheP,
aromatic amino acid:H+ symporter AroP,
choline:H+ symporter (betT),
(R)-lactate / (S)-lactate / glycolate:H+ symporter LldP,
tryptohan / indole:H+ symporter Mtr,
3-hydroxyphenylpropionate / 3-hydroxycinnamate:H+ symporter (mhpT),
Zn2+ / Fe2+ / Cd2+ efflux transporter FieF,
multidrug / spermidine efflux transporter - membrane subunit MdtI,
multidrug / spermidine efflux transporter - membrane subunit MdtJ,
melibiose:H+/Na+/Li+ symporter (melB),
serine / alanine / glycine / cycloserine:H+symporter (cycA),
N-acetylneuraminate:H+ symporter (nanT),
NhaA monomer,
cadaverine:H+ symporter / lysine:cadaverine antiporter (cadB),
putrescine:H+ symporter / putrescine:ornithine antiporter PotE,
EmrE,
L-methionine / branched chain amino acid efflux transporter (yjeH),
nucleoside:H+ symporter NupC,
C4 dicarboxylate / orotate:H+ symporter (dctA),
xylose:H+ symporter (xylE),
serine / threonine:H+ symporter TdcC,
AqpZ monomer,
AmtB monomer,
FocA,
GlpF,
nitrite transporter NirC,
nitrate:nitrite antiporter NarK,
lysophospholipid transporter (lplT),
Ni2+ / Co2+ / Mg2+ transporter (corA),
LptC,
lipid III flippase (wzxE),
guanine / hypoxanthine transporter GhxP,
guanine / hypoxanthine transporter GhxQ,
manganese export protein (mntP),
tellurite resistance protein / ethidium efflux transporter (tehA),
F- efflux transporter / involved in resistance to camphor-induced chromosome decondensation (crcB),
fructoselysine / psicoselysine transporter (frlA),
putative inorganic phosphate export protein (yjbB),
L-lysine efflux transporter (lysO),
adenine transporter (adeQ),
S-methyl-L-methionine transporter (mmuP),
FMN / FAD exporter (yeeO),
undecaprenyl-phosphate-α-L-Ara4N flippase - ArnF subunit,
undecaprenyl-phosphate-α-L-Ara4N flippase - ArnE subunit,
C4 dicarboxylate transporter DauA,
cystine efflux transporter (yijE),
proline:Na+ symporter (putP),
lipid II flippase (murJ),
essential cell division protein FtsW; lipid II flippase,
L-alanine exporter (alaE),
ActP monomer,
L-arginine efflux transporter (argO),
biotin transporter (yigM),
nicotinamide riboside transporter (pnuC),
alkylglycerophosphoethanolamine phosphodiesterase (ENPP2),
sphingolipid 4-desaturase 1 (DEGS1),
N-acetyllactosaminide β-1,3-N-acetylglucosaminyltransferase (B3GNT1),
β-1,3-galactosyl-O-glycosyl-[glycoprotein] β-1,3-N-acetylglucosaminyltransferase 3 (B3GNT3),
ectonucleoside triphosphate diphosphohydrolase 1 monomer (ENTPD1),
Y+L amino acid transporter 2 (SLC7A6),
large neutral amino acids transporter small subunit 2 (SLC7A8),
retinol dehydrogenase 8 (RDH8),
acyl-CoA 4/6/8-desaturase (FADS2)

Unification Links: GO:0005887


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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