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MetaCyc Gene-Ontology-Terms Class: GO:0005887 - integral component of plasma membrane

Definition: The component of the plasma membrane consisting of gene products and protein complexes that have some part that penetrates at least one leaflet of the membrane bilayer. This component includes gene products that are buried in the bilayer with no exposure outside the bilayer.

Parent Classes:
GO:0016021 - integral component of membrane ,
GO:0031226 - intrinsic component of plasma membrane ,
GO:0044459 - plasma membrane part

Child Classes:
GO:0071575 - integral component of external side of plasma membrane (8)

Term Members:
GlpD ,
essential cell division protein FtsI; penicillin-binding protein 3 ,
peptidoglycan synthetase; penicillin-binding protein 1A (mrcA) ,
cell shape; peptidoglycan synthetase; penicillin-binding protein 2 (mrdA) ,
pyridine nucleotide transhydrogenase ,
pyridine nucleotide transhydrogenase, α subunit (pntA) ,
pyridine nucleotide transhydrogenase, β subunit (pntB) ,
D-lactate dehydrogenase (dld) ,
glycerol-3-phosphate acyltransferase (plsB) ,
phosphatidylglycerophosphatase A (pgpA) ,
phosphatidylglycerophosphatase C (pgpC) ,
Rfe ,
trimethylamine N-oxide reductase, c-type cytochrome subunit (torY) ,
NADH:ubiquinone oxidoreductase, membrane subunit N (nuoN) ,
NADH:ubiquinone oxidoreductase, membrane subunit M (nuoM) ,
NADH:ubiquinone oxidoreductase, membrane subunit L (nuoL) ,
NADH:ubiquinone oxidoreductase, membrane subunit K (nuoK) ,
NADH:ubiquinone oxidoreductase, membrane subunit J (nuoJ) ,
NADH:ubiquinone oxidoreductase, membrane subunit H (nuoH) ,
NADH:ubiquinone oxidoreductase, membrane subunit A (nuoA) ,
cytochrome bd-I terminal oxidase ,
cytochrome bd-I terminal oxidase - CydX subunit ,
cytochrome bd-I terminal oxidase subunit II (cydB) ,
cytochrome bd-I terminal oxidase subunit I (cydA) ,
cytochrome bo terminal oxidase ,
cytochrome bo terminal oxidase subunit III (cyoC) ,
cytochrome bo terminal oxidase subunit I (cyoB) ,
cytochrome bo terminal oxidase subunit II (cyoA) ,
cytochrome bo terminal oxidase subunit IV (cyoD) ,
formate dehydrogenase N, γ subunit (fdnI) ,
formate dehydrogenase-O, γ subunit (fdoI) ,
dimethyl sulfoxide reductase, chain C (dmsC) ,
fumarate reductase ,
fumarate reductase membrane protein (frdD) ,
inner membrane protein with thiosulfate sulfurtransferase activity (ygaP) ,
protease IV (sppA) ,
penicillin-binding protein 6 (dacC) ,
phosphoethanolamine transferase (opgE) ,
leader peptidase (signal peptidase I) (lepB) ,
phosphatidylglycerophosphatase [multifunctional] (pgpB) ,
membrane-bound lytic murein transglycosylase A (mltA) ,
protein-tyrosine kinase (wzc) ,
HflK-HflC complex; regulator of FtsH protease ,
D-alanyl-D-alanine carboxypeptidase, fraction A; penicillin-binding protein 5 (dacA) ,
hydrogenase 3 ,
hydrogenase 3, membrane subunit (hycD) ,
phosphatidylglycerol-prolipoprotein diacylglyceryl transferase (lgt) ,
nitrate reductase A, γ subunit (narI) ,
hydrogenase 2 - integral membrane subunit HybB ,
hydrogenase 2 - [Fe-S] binding, ferredoxin-type component HybA ,
formate-dependent nitrite reductase, 4Fe-4S subunit (nrfC) ,
formate dependent nitrite reductase - NrfD subunit ,
murein DD-endopeptidase MepM ,
NADH:quinone oxidoreductase II (ndh) ,
intramembrane serine protease GlpG ,
MalX PTS permease ,
poly-β-1,6-N-acetyl-D-glucosamine synthase ,
poly-β-1,6-N-acetyl-D-glucosamine synthase - PgaC subunit ,
poly-β-1,6-N-acetyl-D-glucosamine synthase - PgaD subunit ,
FocA ,
AmtB monomer ,
GlpF ,
AqpZ monomer ,
lipid II flippase (murJ) ,
essential cell division protein FtsW; lipid II flippase ,
L-alanine exporter (alaE) ,
nicotinamide riboside transporter (pnuC) ,
adenine transporter (adeQ) ,
cystine efflux transporter (yijE) ,
manganese export protein (mntP) ,
Ni2+ / Co2+ / Mg2+ transporter (corA) ,
F- efflux transporter / involved in resistance to camphor-induced chromosome decondensation (crcB) ,
LptC ,
putative inorganic phosphate export protein (yjbB) ,
S-methyl-L-methionine transporter (mmuP) ,
guanine / hypoxanthine transporter GhxP ,
guanine / hypoxanthine transporter GhxQ ,
undecaprenyl-phosphate-α-L-Ara4N flippase - ArnF subunit ,
undecaprenyl-phosphate-α-L-Ara4N flippase - ArnE subunit ,
tellurite resistance protein / ethidium efflux transporter (tehA) ,
C4 dicarboxylate / C4 monocarboxylate transporter DauA ,
NagE ,
2-O-α-mannosyl-D-glycerate PTS permease (mngA) ,
chitobiose PTS permease - ChbC subunit ,
galactitol PTS permease - GatC subunit ,
L-ascorbate PTS permease - UlaA subunit ,
glucose PTS permease - PtsG subunit ,
mannose PTS permease - ManX subunit ,
mannose PTS permease - ManY subunit ,
mannose PTS permease - ManZ subunit ,
trehalose PTS permease - TreB subunit ,
N-acetylmuramic acid PTS permease / anhydro-N-acetylmuramic acid permease (murP) ,
predicted PTS permease - CmtA subunit ,
MtlA ,
sorbitol PTS permease - SrlE subunit ,
sorbitol PTS permease - SrlA subunit ,
aliphatic sulfonate ABC transporter - membrane subunit (ssuC) ,
phosphonate ABC transporter - membrane subunit (phnE_1) ,
ABC complex for formation and release of holoCcmE - membrane subunit CcmC ,
ABC complex for formation and release of holoCcmE - membrane subunit CcmB ,
ABC complex for formation and release of holoCcmE - membrane subunit CcmD ,
glycerol-3-phosphate / glycerophosphodiester ABC transporter ,
glycerol-3-phosphate ABC transporter - membrane subunit (ugpE) ,
glycerol-3-phosphate ABC transporter - membrane subunit (ugpA) ,
glutathione / L-cysteine efflux transporter CydDC ,
glutathione / L-cysteine efflux transporter - CydC subunit ,
glutathione / L-cysteine efflux transporter - CydD subunit ,
phosphate ABC transporter - membrane subunit (pstA) ,
ATP synthase F0 complex - a subunit (atpB) ,
L-cystine ABC transporter - predicted membrane subunit (yecS) ,
L-arginine ABC transporter - membrane subunit (artM) ,
L-arginine ABC transporter - membrane subunit (artQ) ,
ArsB monomer ,
putrescine:H+ symporter PlaP ,
tryptophan:H+ symporter TnaB ,
dipeptide / tripeptide:H+ symporter DtpB ,
dipeptide / tripeptide:H+ symporter DptC (dtpC) ,
dipeptide:H+ symporter DtpD ,
tripeptide / dipeptide:H+ symporter DtpA ,
ActP monomer ,
uracil:H+ symporter UraA ,
uracil:H+ symporter RutG ,
3-hydroxyphenylpropionate / 3-hydroxycinnamate:H+ symporter (mhpT) ,
choline:H+ symporter (betT) ,
arabinose:H+ symporter (araE) ,
ProP ,
spermidine efflux transporter - MdtI subunit ,
(R)-lactate / (S)-lactate / glycolate:H+ symporter LldP ,
glycolate / lactate:H+ symporter (glcA) ,
xylose:H+ symporter (xylE) ,
cytosine transporter (codB) ,
nucleoside:H+ symporter NupG ,
acetate / succinate:H+ symporter (satP) ,
K+ : H+ antiporter KefB ,
KefC ,
xanthine:H+ symporter XanP ,
xanthine:H+ symporter XanQ ,
urate:H+ symporter (uacT) ,
lysine:H+ symporter (lysP) ,
Zn2+ / Fe2+ / Cd2+ efflux transporter FieF ,
O-Acetylserine / cysteine export protein (eamB) ,
hexuronate transporter (exuT) ,
TatA ,
TatE ,
TatC ,
TatB ,
aromatic amino acid exporter (yddG) ,
AdiC monomer ,
Na+ / K+:H+ antiporter ChaA ,
multidrug efflux transporter MdfA (multifunctional) ,
multidrug efflux transporter / bile salt:H+ antiporter / Na+:H+ antiporter / K+:H+ antiporter (mdtM) ,
lactose / melibiose:H+ symporter LacY ,
K+ transporter TrkG ,
K+ transporter TrkH ,
serine:H+ symporter SdaC ,
serine / threonine:H+ symporter TdcC ,
gluconate transporter GntU ,
gluconate / fructuronate transporter GntP ,
EmrE ,
ClcA ,
aromatic amino acid:H+ symporter AroP ,
muropeptide:H+ symporter (ampG) ,
adenine:H+ symporter (adeP) ,
proline:Na+ symporter (putP) ,
tryptohan / indole:H+ symporter Mtr ,
serine / alanine / glycine / cycloserine:H+symporter (cycA) ,
nucleoside:H+ symporter NupC ,
C4 dicarboxylate / orotate:H+ symporter (dctA) ,
N-acetylneuraminate:H+ symporter (nanT) ,
melibiose:H+/Na+/Li+ symporter (melB) ,
nitrate / nitrite transporter NarU ,
nitrate:nitrite antiporter NarK ,
hexose-6-phosphate:phosphate antiporter (uhpT) ,
vitamin B12 ABC transporter ,
vitamin B12 ABC transporter - membrane subunit (btuC) ,
ferric enterobactin ABC transporter - membrane subunit (fepD) ,
ferric enterobactin ABC transporter - membrane subunit (fepG) ,
protein disulfide oxidoreductase - DsbDreduced ,
predicted PTS permease - FrwC subunit ,
fructose PTS permease - FruA subunit ,
predicted PTS permease - SgcC subunit ,
N-acetyllactosaminide β-1,3-N-acetylglucosaminyltransferase (B3GNT1) ,
β-1,3-galactosyl-O-glycosyl-[glycoprotein] β-1,3-N-acetylglucosaminyltransferase 3 (B3GNT3) ,
ectonucleoside triphosphate diphosphohydrolase 1 monomer (ENTPD1) ,
Y+L amino acid transporter 2 (SLC7A6) ,
large neutral amino acids transporter small subunit 2 (SLC7A8) ,
retinol dehydrogenase 8 (RDH8) ,
acyl-CoA 6-desaturase (FADS2)

Unification Links: GO:0005887


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sat Apr 18, 2015, biocyc13.