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MetaCyc EC 6.5.1 -- Ligases that form phosphoric-ester bonds

Parent Class: EC-Numbers 6 -- Ligases 6.5 -- Forming phosphoric ester bonds

Instances:
6.5.1.1 -- DNA ligase (ATP) ,
6.5.1.2 -- DNA ligase (NAD+) ,
6.5.1.3 -- RNA ligase (ATP) ,
6.5.1.4 -- RNA 3′-terminal-phosphate cyclase (ATP) ,
6.5.1.5 -- RNA 3′-terminal-phosphate cyclase (GTP) ,
6.5.1.6 -- DNA ligase (ATP or NAD+) ,
6.5.1.7 -- DNA ligase (ATP, ADP or GTP)

Unofficial Reactions:
a 5' half-tRNA molecule with a 2',3' cyclic phosphate on its 3' end + a 3' half-tRNA molecule with a hydroxyl on its 5' end + 2 ATP + H2O → a 2'-phospho-[ligated tRNA] + AMP + ADP + diphosphate + 2 H+ ,
a 5' half-tRNA molecule with a 2',3' cyclic phosphate on its 3' end + a 3' half-tRNA molecule with a hydroxyl on its 5' end ↔ a ligated tRNA with a 2'-5' linkage

Enzymes and Genes:
RNA 2',3'-cyclic phosphodiesterase : thpR ( Escherichia coli K-12 substr. MG1655 )
tRNA ligase : TRL1 ( Saccharomyces cerevisiae )


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Fri Mar 27, 2015, biocyc13.