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MetaCyc EC 4.1.1 -- Carboxy-lyases

Parent Class: EC-Numbers4 -- Lyases4.1 -- Carbon-carbon lyases

Instances:
4.1.1.1 -- pyruvate decarboxylase,
4.1.1.2 -- oxalate decarboxylase,
4.1.1.3 -- oxaloacetate decarboxylase,
4.1.1.4 -- acetoacetate decarboxylase,
4.1.1.5 -- acetolactate decarboxylase,
4.1.1.6 -- aconitate decarboxylase,
4.1.1.7 -- benzoylformate decarboxylase,
4.1.1.8 -- oxalyl-CoA decarboxylase,
4.1.1.9 -- malonyl-CoA decarboxylase,
4.1.1.11 -- aspartate 1-decarboxylase,
4.1.1.12 -- aspartate 4-decarboxylase,
4.1.1.14 -- valine decarboxylase,
4.1.1.15 -- glutamate decarboxylase,
4.1.1.16 -- hydroxyglutamate decarboxylase,
4.1.1.17 -- ornithine decarboxylase,
4.1.1.18 -- lysine decarboxylase,
4.1.1.19 -- arginine decarboxylase,
4.1.1.20 -- diaminopimelate decarboxylase,
4.1.1.21 -- phosphoribosylaminoimidazole carboxylase,
4.1.1.22 -- histidine decarboxylase,
4.1.1.23 -- orotidine-5′-phosphate decarboxylase,
4.1.1.24 -- aminobenzoate decarboxylase,
4.1.1.25 -- tyrosine decarboxylase,
4.1.1.28 -- aromatic-L-amino-acid decarboxylase,
4.1.1.29 -- sulfinoalanine decarboxylase,
4.1.1.30 -- pantothenoylcysteine decarboxylase,
4.1.1.31 -- phosphoenolpyruvate carboxylase,
4.1.1.32 -- phosphoenolpyruvate carboxykinase (GTP),
4.1.1.33 -- diphosphomevalonate decarboxylase,
4.1.1.34 -- dehydro-L-gulonate decarboxylase,
4.1.1.35 -- UDP-glucuronate decarboxylase,
4.1.1.36 -- phosphopantothenoylcysteine decarboxylase,
4.1.1.37 -- uroporphyrinogen decarboxylase,
4.1.1.38 -- phosphoenolpyruvate carboxykinase (diphosphate),
4.1.1.39 -- ribulose-bisphosphate carboxylase,
4.1.1.40 -- hydroxypyruvate decarboxylase,
4.1.1.41 -- methylmalonyl-CoA decarboxylase,
4.1.1.42 -- carnitine decarboxylase,
4.1.1.43 -- phenylpyruvate decarboxylase,
4.1.1.44 -- 4-carboxymuconolactone decarboxylase,
4.1.1.45 -- aminocarboxymuconate-semialdehyde decarboxylase,
4.1.1.46 -- o-pyrocatechuate decarboxylase,
4.1.1.47 -- tartronate-semialdehyde synthase,
4.1.1.48 -- indole-3-glycerol-phosphate synthase,
4.1.1.49 -- phosphoenolpyruvate carboxykinase (ATP),
4.1.1.50 -- adenosylmethionine decarboxylase,
4.1.1.51 -- 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase,
4.1.1.52 -- 6-methylsalicylate decarboxylase,
4.1.1.53 -- phenylalanine decarboxylase,
4.1.1.54 -- dihydroxyfumarate decarboxylase,
4.1.1.55 -- 4,5-dihydroxyphthalate decarboxylase,
4.1.1.56 -- 3-oxolaurate decarboxylase,
4.1.1.57 -- methionine decarboxylase,
4.1.1.58 -- orsellinate decarboxylase,
4.1.1.59 -- gallate decarboxylase,
4.1.1.60 -- stipitatonate decarboxylase,
4.1.1.61 -- 4-hydroxybenzoate decarboxylase,
4.1.1.62 -- gentisate decarboxylase,
4.1.1.63 -- protocatechuate decarboxylase,
4.1.1.64 -- 2,2-dialkylglycine decarboxylase (pyruvate),
4.1.1.65 -- phosphatidylserine decarboxylase,
4.1.1.66 -- uracil-5-carboxylate decarboxylase,
4.1.1.67 -- UDP-galacturonate decarboxylase,
4.1.1.68 -- 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase,
4.1.1.69 -- 3,4-dihydroxyphthalate decarboxylase,
4.1.1.70 -- glutaconyl-CoA decarboxylase,
4.1.1.71 -- 2-oxoglutarate decarboxylase,
4.1.1.72 -- branched-chain-2-oxoacid decarboxylase,
4.1.1.73 -- tartrate decarboxylase,
4.1.1.74 -- indolepyruvate decarboxylase,
4.1.1.75 -- 5-guanidino-2-oxopentanoate decarboxylase,
4.1.1.76 -- arylmalonate decarboxylase,
4.1.1.77 -- 2-oxo-3-hexenedioate decarboxylase,
4.1.1.78 -- acetylenedicarboxylate decarboxylase,
4.1.1.79 -- sulfopyruvate decarboxylase,
4.1.1.80 -- 4-hydroxyphenylpyruvate decarboxylase,
4.1.1.81 -- threonine-phosphate decarboxylase,
4.1.1.82 -- phosphonopyruvate decarboxylase,
4.1.1.83 -- 4-hydroxyphenylacetate decarboxylase,
4.1.1.84 -- D-dopachrome decarboxylase,
4.1.1.85 -- 3-dehydro-L-gulonate-6-phosphate decarboxylase,
4.1.1.86 -- diaminobutyrate decarboxylase,
4.1.1.87 -- malonyl-S-ACP decarboxylase,
4.1.1.88 -- biotin-independent malonate decarboxylase,
4.1.1.89 -- biotin-dependent malonate decarboxylase,
4.1.1.90 -- peptidyl-glutamate 4-carboxylase,
4.1.1.91 -- salicylate decarboxylase,
4.1.1.92 -- indole-3-carboxylate decarboxylase,
4.1.1.93 -- pyrrole-2-carboxylate decarboxylase,
4.1.1.94 -- ethylmalonyl-CoA decarboxylase,
4.1.1.95 -- L-glutamyl-[BtrI acyl-carrier protein] decarboxylase,
4.1.1.96 -- carboxynorspermidine decarboxylase,
4.1.1.97 -- 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase,
4.1.1.98 -- 4-hydroxy-3-polyprenylbenzoate decarboxylase,
4.1.1.99 -- phosphomevalonate decarboxylase,
4.1.1.100 -- prephenate decarboxylase,
4.1.1.101 -- malolactic enzyme,
4.1.1.M2 -- phenacrylate decarboxylase,
4.1.1.M3

Unofficial Reactions:
3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H+ → 2-hexaprenyl-6-methoxyphenol + CO2,
2-oxopent-5-chloro-3-enoate + H+ → 2-oxo-5-chloro-4-pentenoate + CO2,
3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate + H+ → 2-methoxy-6-(all-trans-decaprenyl)phenol + CO2,
3-hexaprenyl-4-amino-5-methoxybenzoate + H+ → 2-hexaprenyl-6-methoxyaminobenzene + CO2,
2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate + H+ ↔ 2-hydroxy-6-oxo-7-methyl-octa-2,4-dienoate + CO2,
naphthalene + hydrogen carbonate → 2-naphthoate + H2O,
a 3-oxoacid + H+ → a methyl ketone + CO2,
3-methoxy-4-hydroxy-5-all-trans-heptaprenylbenzoate + H+ → 2-methoxy-6-(all-trans-heptaprenyl)phenol + CO2,
(-)-dehydrodiconiferyl acid carboxylate + H+ → 4,2'-dihydroxy-3,3'-dimethoxy-5'-(2''-carboxyvinyl)stilbene + CO2,
3,6,8-trimethyl-2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline + an oxidized unknown electron acceptor + H+S-(+)-3,6,8-trimethylallantoin + CO2 + an reduced unknown electron acceptor,
L-serine + H+ → ethanolamine + CO2,
2-phosphoglycolate + 3-phospho-D-glycerate + 2 H+ → D-ribulose-1,5-bisphosphate + oxygen,
UDP-α-D-glucuronate + H+ → UDP-D-apiose + CO2,
siroheme + 2 H+ → 12,18-didecarboxysiroheme + 2 CO2,
15-demethoxy-aclacinomycin A + an reduced unknown electron acceptor + H+ + oxygen → 10-decarboxymethyl, 10-hydroxyaclacinomycin A + CO2 + an oxidized unknown electron acceptor + H2O,
5-carboxyvanillate + H+ → vanillate + CO2,
3-methoxy-4-hydroxy-5-all-trans-nonaprenylbenzoate + H+ → 2-methoxy-6-(all-trans-nonaprenyl)phenol + CO2,
2-oxovalerate + H+ → butanal + CO2,
10-carboxy-3-deoxycarminomycin + H+ → 13-deoxycarminomycin + CO2,
carboxyspermidine + H+ → spermidine + CO2,
cytosyl-β-D-glucuronate + 2 S-adenosyl-L-methionine + 2 a reduced flavodoxin = cytosyl-α-L-arabinopyranose + CO2 + 2 5'-deoxyadenosine + 2 L-methionine + 2 an oxidized flavodoxin + H+,
3-phosphonomethylmalate + an oxidized unknown electron acceptor + H+ → 2-oxo-4-phosphonobutanoate + CO2 + an reduced unknown electron acceptor,
15-demethoxy-ε-rhodomycinone + H+ → 15-decarboxymethyl-ε-rhodomycinone + CO2,
3-carboxy-2-hydroxymuconate semialdehyde + H+ → (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + CO2,
3-methoxy-4-hydroxy-5-all-trans-octaprenylbenzoate + H+ → 2-methoxy-6-(all-trans-octaprenyl)phenol + CO2,
5-chloro-4-hydroxy-2-oxopentanoate + 2 an oxidized ferredoxin [iron-sulfur] cluster + coenzyme A → 4-chloro-3-hydroxybutyryl-CoA + CO2 + 2 a reduced ferredoxin [iron-sulfur] cluster + H+,
2-oxo-3-carboxy-4,5-cyclopropylhex-5-enoate + H+ → beta-methylenecyclopropyl pyruvate + CO2,
γ-L-glutamyl-(S)-2-carboxypropyl-L-cysteinyl-glycine + an oxidized unknown electron acceptor + H+ → γ-L-glutamyl-(S)-allyl-L-cysteinyl-glycine + CO2 + an reduced unknown electron acceptor,
4-amino-2-(methanethioyl)-5-oxo-3-sulfanylpyrrolidine-2-carboxylate + H+ → (5E)-3-amino-4-sulfanyl-5-(sulfanylmethylidene)pyrrolidin-2-one + CO2,
15-demethoxyaclacinomycin T + an reduced unknown electron acceptor + H+ + oxygen → 10-decarboxymethylaclacinomycin T + CO2 + an oxidized unknown electron acceptor + H2O

Enzymes and Genes:
Lantibiotic biosynthesis protein: hlmF ( Streptomyces clavuligerus )
5-chloro-4-hydroxy-2-oxopentanoate decarboxylase (acylating): salQ ( Salinispora tropica )
3-carboxy-2-hydroxymuconate semialdehyde decarboxylase: dhbB ( Pseudomonas reinekei )
cytosinine synthase: blsE ( Streptomyces griseochromogenes )
carboxyspermidine decarboxylase: C8J_1418 ( Campylobacter jejuni jejuni 81116 )
carboxynorspermidine decarboxylase: VVI_3048 ( Vibrio vulnificus CMCP6 )
carboxynorspermidine decarboxylase: nspC ( Vibrio alginolyticus NBRC 15630 = ATCC 17749 )
pyruvate decarboxylase 3: PDC6 ( Saccharomyces cerevisiae )
pyruvate decarboxylase 2: PDC5 ( Saccharomyces cerevisiae )
pyruvate decarboxylase 1: PDC1 ( Saccharomyces cerevisiae )
5-carboxyvanillate decarboxylase: ligW2 ( Sphingomonas sp. SYK6 )
5-carboxyvanillate decarboxylase: ligW ( Sphingomonas sp. SYK6 )
aclacinomycin 10-hydroxylase: rdmB ( Streptomyces purpurascens )
siroheme decarboxylase: ahbB, ahbA ( Desulfovibrio desulfuricans )
siroheme decarboxylase: nirH, nirG, nirD-L ( Paracoccus pantotrophus )
UDP-D-xylose synthase / UDP-D-apiose synthase ( Petroselinum crispum )
UDP-D-apiose synthase / UDP-D-xylose synthase: AXS1 ( Arabidopsis thaliana col )
ribulose bisphosphate carboxylase: cbbS, cbbL ( Synechocystis sp. PCC 6803 )
ribulose bisphosphate carboxylase/oxygenase: RBCS-2B, RBCL ( Arabidopsis thaliana col )
ribulose bisphosphate carboxylase/oxygenase: RBCS-3B, RBCL ( Arabidopsis thaliana col )
ribulose bisphosphate carboxylase/oxygenase: RBCL, RBCS-1A ( Arabidopsis thaliana col )
ribulose bisphosphate carboxylase/oxygenase: RBSS-1B, RBCL ( Arabidopsis thaliana col )
serine decarboxylase ( Spinacia oleracea )
serine decarboxylase: AtSDC ( Arabidopsis thaliana col )
serine decarboxylase: BnSDC ( Brassica napus )
methylketone synthase 1: MKS1 ( Lycopersicon hirsutum glabratum )
naphthalene carboxylase: N47_K27500, N47_K27540 ( delta proteobacterium N47 )
HCOMODA decarboxylase: cmtD ( Pseudomonas putida F1 )
2-oxo-3-hexenedioate decarboxylase / 2-oxopent-5-chloro-3-enoate decarboxylase: cnbF ( Comamonas testosteroni CNB-1 )


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Tue Feb 9, 2016, biocyc14.