Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
twitter

MetaCyc EC 1.2.1 -- With NAD(+) or NADP(+) as acceptor

Parent Class: EC-Numbers 1 -- Oxidoreductases 1.2 -- Acting on the aldehyde or oxo group of donors

Instances:
1.2.1.2 -- formate dehydrogenase ,
1.2.1.3 -- aldehyde dehydrogenase (NAD+) ,
1.2.1.4 -- aldehyde dehydrogenase (NADP+) ,
1.2.1.5 -- aldehyde dehydrogenase [NAD(P)+] ,
1.2.1.7 -- benzaldehyde dehydrogenase (NADP+) ,
1.2.1.8 -- betaine-aldehyde dehydrogenase ,
1.2.1.9 -- glyceraldehyde-3-phosphate dehydrogenase (NADP+) ,
1.2.1.10 -- acetaldehyde dehydrogenase (acetylating) ,
1.2.1.11 -- aspartate-semialdehyde dehydrogenase ,
1.2.1.12 -- glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) ,
1.2.1.13 -- glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) ,
1.2.1.15 -- malonate-semialdehyde dehydrogenase ,
1.2.1.17 -- glyoxylate dehydrogenase (acylating) ,
1.2.1.18 -- malonate-semialdehyde dehydrogenase (acetylating) ,
1.2.1.19 -- aminobutyraldehyde dehydrogenase ,
1.2.1.20 -- glutarate-semialdehyde dehydrogenase ,
1.2.1.21 -- glycolaldehyde dehydrogenase ,
1.2.1.22 -- lactaldehyde dehydrogenase ,
1.2.1.23 -- 2-oxoaldehyde dehydrogenase (NAD+) ,
1.2.1.24 -- succinate-semialdehyde dehydrogenase (NAD+) ,
1.2.1.25 -- 2-oxoisovalerate dehydrogenase (acylating) ,
1.2.1.26 -- 2,5-dioxovalerate dehydrogenase ,
1.2.1.27 -- methylmalonate-semialdehyde dehydrogenase (CoA-acylating) ,
1.2.1.28 -- benzaldehyde dehydrogenase (NAD+) ,
1.2.1.29 -- aryl-aldehyde dehydrogenase ,
1.2.1.30 -- aryl-aldehyde dehydrogenase (NADP+) ,
1.2.1.31 -- L-aminoadipate-semialdehyde dehydrogenase ,
1.2.1.32 -- aminomuconate-semialdehyde dehydrogenase ,
1.2.1.33 -- (R)-dehydropantoate dehydrogenase ,
1.2.1.36 -- retinal dehydrogenase ,
1.2.1.38 -- N-acetyl-γ-glutamyl-phosphate reductase ,
1.2.1.39 -- phenylacetaldehyde dehydrogenase ,
1.2.1.41 -- glutamate-5-semialdehyde dehydrogenase ,
1.2.1.42 -- hexadecanal dehydrogenase (acylating) ,
1.2.1.43 -- formate dehydrogenase (NADP+) ,
1.2.1.44 -- cinnamoyl-CoA reductase ,
1.2.1.46 -- formaldehyde dehydrogenase ,
1.2.1.47 -- 4-trimethylammoniobutyraldehyde dehydrogenase ,
1.2.1.48 -- long-chain-aldehyde dehydrogenase ,
1.2.1.49 -- 2-oxoaldehyde dehydrogenase (NADP+) ,
1.2.1.50 -- long-chain-fatty-acyl-CoA reductase ,
1.2.1.51 -- pyruvate dehydrogenase (NADP+) ,
1.2.1.52 -- oxoglutarate dehydrogenase (NADP+) ,
1.2.1.53 -- 4-hydroxyphenylacetaldehyde dehydrogenase ,
1.2.1.54 -- γ-guanidinobutyraldehyde dehydrogenase ,
1.2.1.57 -- butanal dehydrogenase ,
1.2.1.58 -- phenylglyoxylate dehydrogenase (acylating) ,
1.2.1.59 -- glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) ,
1.2.1.60 -- 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase ,
1.2.1.61 -- 4-hydroxymuconic-semialdehyde dehydrogenase ,
1.2.1.62 -- 4-formylbenzenesulfonate dehydrogenase ,
1.2.1.63 -- 6-oxohexanoate dehydrogenase ,
1.2.1.64 -- 4-hydroxybenzaldehyde dehydrogenase ,
1.2.1.65 -- salicylaldehyde dehydrogenase ,
1.2.1.67 -- vanillin dehydrogenase ,
1.2.1.68 -- coniferyl-aldehyde dehydrogenase ,
1.2.1.69 -- fluoroacetaldehyde dehydrogenase ,
1.2.1.70 -- glutamyl-tRNA reductase ,
1.2.1.71 -- succinylglutamate-semialdehyde dehydrogenase ,
1.2.1.72 -- erythrose-4-phosphate dehydrogenase ,
1.2.1.73 -- sulfoacetaldehyde dehydrogenase ,
1.2.1.74 -- abieta-7,13-dien-18-al dehydrogenase ,
1.2.1.75 -- malonyl-CoA reductase (malonate semialdehyde-forming) ,
1.2.1.76 -- succinate-semialdehyde dehydrogenase (acylating) ,
1.2.1.77 -- 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP+) ,
1.2.1.78 -- 2-formylbenzoate dehydrogenase ,
1.2.1.79 -- succinate-semialdehyde dehydrogenase (NADP+) ,
1.2.1.80 -- long-chain acyl-[acyl-carrier-protein] reductase ,
1.2.1.81 -- sulfoacetaldehyde dehydrogenase (acylating) ,
1.2.1.82 -- β-apo-4′-carotenal oxygenase ,
1.2.1.83 -- 3-succinoylsemialdehyde-pyridine dehydrogenase ,
1.2.1.84 -- alcohol-forming fatty acyl-CoA reductase ,
1.2.1.85 -- 2-hydroxymuconate-6-semialdehyde dehydrogenase ,
1.2.1.86 -- geranial dehydrogenase ,
1.2.1.87 -- propanal dehydrogenase (CoA-propanoylating) ,
1.2.1.88 -- L-glutamate γ-semialdehyde dehydrogenase ,
1.2.1.89 -- D-glyceraldehyde dehydrogenase (NADP+) ,
1.2.1.v -- glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+]

Unofficial Reactions:
malonate semialdehyde + coenzyme A + NADP+ = acetyl-CoA + CO2 + NADPH ,
1-pyrroline + NAD+ + 2 H2O = 4-aminobutanoate + NADH + 2 H+ ,
chloroacetaldehyde + NAD+ + H2O ↔ chloroacetate + NADH + 2 H+ ,
(S)-2-amino-6-oxohexanoate + NAD+ + H2O = L-2-aminoadipate + NADH + 2 H+ ,
4-carboxybenzaldehyde + NAD+ + H2O ↔ terephthalate + NADH + 2 H+ ,
apo-4'-lycopenal + NAD(P)+ + H2O → apo-4'-lycopenoate + NADPH + H+ ,
22-oxo-docosanoate + NADP+ + H2O → docosanedioate + NADPH + 2 H+ ,
(S)-lactaldehyde + NADP+ + H2O → (S)-lactate + NADPH + 2 H+ ,
3-aminopropanal + NAD+ + H2O = β-alanine + NADH + 2 H+ ,
phosphonoacetaldehyde + NAD+ + H2O → phosphonoacetate + NADH + 2 H+ ,
hexanal + coenzyme A + NAD(P)+ ← hexanoyl-CoA + NAD(P)H + H+ ,
3-oxo-24-ethyl-26-al-cholest-4-ene + NAD+ + H2O → 3-oxo-24-ethyl-cholest-4-en-26-oate + NADH + 2 H+ ,
3-oxocholest-4-en-26-al + NAD+ + H2O → 3-oxocholest-4-en-26-oate + NADH + 2 H+ ,
a long-chain aldehyde + coenzyme A + NAD+ ← a long-chain acyl-CoA + NADH + H+ ,
(15Z)-tetracos-15-enal + coenzyme A + NAD+ ← (Z)-15-tetracosenoyl-CoA + NADH + H+ ,
a long-chain aldehyde + NADH + H+ → a long-chain alcohol + NAD+ ,
4-hydroxybenzaldehyde + NAD(P)+ + H2O → 4-hydroxybenzoate + NAD(P)H + 2 H+ ,
4-aminobutanal + NADP+ + H2O = 4-aminobutanoate + NADPH + 2 H+ ,
L-4-hydroxyglutamate semialdehyde + NAD+ + H2O → erythro-4-hydroxy-L-glutamate + NADH + 2 H+ ,
glycolaldehyde + an oxidized electron acceptor → glycolate + a reduced electron acceptor + H+ ,
(10E,12Z)-10,12-hexadecadienoate + 2 NADPH + 3 H+ → bombykol + 2 NADP+ + H2O ,
gentisaldehyde + NADP+ + H2O → gentisate + NADPH + 2 H+ ,
4-guanidinobutyraldehyde + an oxidized electron acceptor + H2O → 4-guanidinobutyrate + a reduced electron acceptor + H+ ,
18-oxo-oleate + NADP+ + H2O → α,ω-9Z-octadecenedioate + NADPH + 2 H+ ,
malonate semialdehyde + coenzyme A + NAD+ → acetyl-CoA + CO2 + NADH ,
an ω-oxo fatty acid + NAD+ + H2O → an α,ω-dicarboxylate + NADH + H+ ,
a [LysW]-C-terminal-L-glutamyl-γ-L-2-aminoadipate 6-phosphate + NADPH + H+ → a [LysW]-C-terminal-L-glutamyl-γ-L-2-aminoadipate semialdehyde + NADP+ + phosphate ,
indole-3-glycol aldehyde + an oxidized electron acceptor + H2O → indole-3-glycolate + a reduced electron acceptor + H+ ,
indole-3-glyoxal + an oxidized electron acceptor + H2O → indole-3-glyoxylate + a reduced electron acceptor + H+ ,
3-aminopropanal + NAD(P)+ + H2O → β-alanine + NAD(P)H + 2 H+ ,
sinapaldehyde + NADP+ + H2O → sinapate + NADPH + 2 H+ ,
(S)-2,3,4,5-tetrahydropiperidine-2-carboxylate + NAD+ + 2 H2O → L-2-aminoadipate + NADH + H+ ,
glutarate semialdehyde + NADP+ + H2O → glutarate + NADPH + 2 H+ ,
bixin aldehyde + NAD+ + oxygen → norbixin + NADH + H+ ,
2,5-dioxopentanoate + NAD(P)+ + H2O → 2-oxoglutarate + NAD(P)H + 2 H+ ,
16-oxo-palmitate + NADP+ + H2O → hexadecanedioate + NADPH + 2 H+ ,
4-(γ-glutamylamino)butanal + NAD(P)+ + H2O → 4-(γ-L-glutamylamino)butanoate + NAD(P)H + 2 H+ ,
3-hydroxypropionaldehyde + NAD+ + H2O → 3-hydroxypropanoate + NADH + 2 H+ ,
a very long chain alcohol + coenzyme A + 2 NADP+ ← a very long chain fatty acyl-CoA + 2 NADPH + 2 H+ ,
(S)-3-methyl-2-oxopentanoate + coenzyme A + NAD+ ↔ 2-methylbutanoyl-CoA + CO2 + NADH ,
4-methyl-2-oxopentanoate + coenzyme A + NAD+ → isovaleryl-CoA + CO2 + NADH ,
pyruvate + coenzyme A + NAD+ ↔ acetyl-CoA + CO2 + NADH

Enzymes and Genes:
pyruvate dehydrogenase : aceE , aceF , lpd ( Escherichia coli K-12 substr. MG1655 )
pyruvate dehydrogenase complex : pdhB , Synpcc7942_1944 , pdhC , pdhD ( Synechococcus elongatus PCC 7942 )
pyruvate dehydrogenase complex : DLD , AF123459 , DLAT , PDHA1 , PDHB ( Ascaris suum )
pyruvate dehydrogenase complex : PDHA1 , PDHB , DLAT , PDHX , DLD ( Homo sapiens )
pyruvate dehydrogenase complex ( Crithidia fasciculata )
pyruvate dehydrogenase complex ( Pisum sativum )
pyruvate dehydrogenase complex : pdhB , pdhA , pdhC , pdhD ( Mycoplasma pneumoniae M129 )
branched-chain α-keto acid dehydrogenase complex : BCKDHB , BCKDHA , DBT , DLD ( Homo sapiens )
branched-chain α-keto acid dehydrogenase complex : bfmBAB , bfmBAA , bfmBB , pdhD ( Bacillus subtilis )
alcohol-forming fatty acyl-CoA reductase : CER4 ( Arabidopsis thaliana col )
γ-glutamyl-γ-aminobutyraldehyde dehydrogenase : puuC ( Escherichia coli K-12 substr. MG1655 )
2-ketoglutarate semialdehyde dehydrogenase : PA2217 ( Pseudomonas aeruginosa PAO1 )
α-ketoglutaric semialdehyde dehydrogenase : araE ( Azospirillum brasilense )
bixin aldehyde dehydrogenase : BADH ( Bixa orellana )
glutarate semialdehyde dehydrogenase : PA0265 ( Pseudomonas aeruginosa )
glutarate semialdehyde dehydrogenase : davD ( Pseudomonas putida )
α aminoadipate reductase : LYS2 ( Saccharomyces cerevisiae )
hydroxycinnamaldehyde dehydrogenase : REF1 ( Arabidopsis thaliana col )
[LysW]-L-2-aminoadipate/[LysW]-L-glutamate phosphate reductase : lysY ( Sulfolobus acidocaldarius )
[LysW]-L-2-aminoadipate 6-phosphate reductase : lysY ( Thermus thermophilus )
(methyl)malonate-semialdehyde dehydrogenase : mmsA ( Bacillus subtilis subtilis 168 )
malonate-semialdehyde dehydrogenase ( Enterobacter aerogenes )
malonate semialdehyde dehydrogenase ( Pseudomonas fluorescens )
malonate semialdehyde dehydrogenase ( Rattus norvegicus )
pheromone gland-specific fatty-acyl reductase : FAR ( Bombyx mori )
glycolaldehyde oxidoreductase : SSO2637 , SSO2636 , SSO2639 ( Sulfolobus solfataricus P2 )
Δ1-pyrroline-5-carboxylate dehydrogenase, mitochondrial : ALDH4A1 ( Homo sapiens )
Δ1-pyrroline-5-carboxylate dehydrogenase ( Bos taurus )
acyl-CoA reductase (NADH) : U80676 ( Botryococcus braunii BOT88-2 )
cholest-4-en-3-one 26-monooxygenase : cyp125 ( Mycobacterium tuberculosis )
cholest-4-en-3-one 26-monooxygenase : cyp125 ( Rhodococcus jostii RHA1 )
aldehyde/alcohol dehydrogenase : adhE2 ( Clostridium acetobutylicum )
phosphonoacetaldehyde dehydrogenase : phnY ( Sinorhizobium meliloti 1021 )
betaine aldehyde / aminoaldehyde dehydrogenase : ALDH10A9 ( Arabidopsis thaliana col )
3-aminopropionaldehyde dehydrogenase ( Setaria italica )
aminopropionaldehyde dehydrogenase ( Arthrobacter sp. TMP-1 )
aldehyde dehydrogenase : ALD2 ( Saccharomyces cerevisiae )
aldehyde dehydrogenase : ALD3 ( Saccharomyces cerevisiae )
NAD(P)+ L-lactaldehyde dehydrogenase : LADH ( Scheffersomyces stipitis CBS 6054 )
aldehyde dehydrogenase, mitochondrial : ALD5 ( Saccharomyces cerevisiae )
potassium-activated aldehyde dehydrogenase, mitochondrial : ALD4 ( Saccharomyces cerevisiae )
NADPH-dependent aldehyde reductase : yqhD ( Escherichia coli K-12 substr. MG1655 )
apo-4'-lycopenal dehydrogenase : YLO-1 ( Neurospora crassa )
4-carboxybenzaldehyde dehydrogenase / 4-sulfobenzaldehyde dehydrogenase : tsaD ( Comamonas testosteroni T-2 )
Δ1-piperideine-6-carboxylate dehydrogenase : pcd ( [Flavobacterium] lutescens )
Δ1-piperideine-6-carboxylate dehydrogenase : pcd ( Streptomyces clavuligerus )
L-α-aminoadipate δ-semialdehyde:NAD oxidoreductase : amaA ( Pseudomonas putida )
α-aminoadipic semialdehyde dehydrogenase : ALDH7A1 ( Homo sapiens )
chloroacetaldehyde dehydrogenase ( Xanthobacter autotrophicus )
malonate-semialdehyde dehydrogenase (acetylating) : dddC ( Halomonas sp. HTNK1 )


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Dec 20, 2014, BIOCYC13B.