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June 28th 2015
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June 28th 2015
Join us at the Metabolomics Conference tutorial
June 28th 2015
Join us at the Metabolomics Conference tutorial
June 28th 2015
Join us at the Metabolomics Conference tutorial
June 28th 2015
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MetaCyc EC 1.2.1 -- With NAD(+) or NADP(+) as acceptor

Parent Class: EC-Numbers 1 -- Oxidoreductases 1.2 -- Acting on the aldehyde or oxo group of donors

Instances:
1.2.1.2 -- formate dehydrogenase ,
1.2.1.3 -- aldehyde dehydrogenase (NAD+) ,
1.2.1.4 -- aldehyde dehydrogenase (NADP+) ,
1.2.1.5 -- aldehyde dehydrogenase [NAD(P)+] ,
1.2.1.7 -- benzaldehyde dehydrogenase (NADP+) ,
1.2.1.8 -- betaine-aldehyde dehydrogenase ,
1.2.1.9 -- glyceraldehyde-3-phosphate dehydrogenase (NADP+) ,
1.2.1.10 -- acetaldehyde dehydrogenase (acetylating) ,
1.2.1.11 -- aspartate-semialdehyde dehydrogenase ,
1.2.1.12 -- glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) ,
1.2.1.13 -- glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) ,
1.2.1.15 -- malonate-semialdehyde dehydrogenase ,
1.2.1.16 -- succinate-semialdehyde dehydrogenase [NAD(P)+] ,
1.2.1.17 -- glyoxylate dehydrogenase (acylating) ,
1.2.1.18 -- malonate-semialdehyde dehydrogenase (acetylating) ,
1.2.1.19 -- aminobutyraldehyde dehydrogenase ,
1.2.1.20 -- glutarate-semialdehyde dehydrogenase ,
1.2.1.21 -- glycolaldehyde dehydrogenase ,
1.2.1.22 -- lactaldehyde dehydrogenase ,
1.2.1.23 -- 2-oxoaldehyde dehydrogenase (NAD+) ,
1.2.1.24 -- succinate-semialdehyde dehydrogenase (NAD+) ,
1.2.1.25 -- 2-oxoisovalerate dehydrogenase (acylating) ,
1.2.1.26 -- 2,5-dioxovalerate dehydrogenase ,
1.2.1.27 -- methylmalonate-semialdehyde dehydrogenase (CoA-acylating) ,
1.2.1.28 -- benzaldehyde dehydrogenase (NAD+) ,
1.2.1.29 -- aryl-aldehyde dehydrogenase ,
1.2.1.30 -- aryl-aldehyde dehydrogenase (NADP+) ,
1.2.1.31 -- L-aminoadipate-semialdehyde dehydrogenase ,
1.2.1.32 -- aminomuconate-semialdehyde dehydrogenase ,
1.2.1.33 -- (R)-dehydropantoate dehydrogenase ,
1.2.1.36 -- retinal dehydrogenase ,
1.2.1.38 -- N-acetyl-γ-glutamyl-phosphate reductase ,
1.2.1.39 -- phenylacetaldehyde dehydrogenase ,
1.2.1.41 -- glutamate-5-semialdehyde dehydrogenase ,
1.2.1.42 -- hexadecanal dehydrogenase (acylating) ,
1.2.1.43 -- formate dehydrogenase (NADP+) ,
1.2.1.44 -- cinnamoyl-CoA reductase ,
1.2.1.46 -- formaldehyde dehydrogenase ,
1.2.1.47 -- 4-trimethylammoniobutyraldehyde dehydrogenase ,
1.2.1.48 -- long-chain-aldehyde dehydrogenase ,
1.2.1.49 -- 2-oxoaldehyde dehydrogenase (NADP+) ,
1.2.1.50 -- long-chain-fatty-acyl-CoA reductase ,
1.2.1.51 -- pyruvate dehydrogenase (NADP+) ,
1.2.1.52 -- oxoglutarate dehydrogenase (NADP+) ,
1.2.1.53 -- 4-hydroxyphenylacetaldehyde dehydrogenase ,
1.2.1.54 -- γ-guanidinobutyraldehyde dehydrogenase ,
1.2.1.57 -- butanal dehydrogenase ,
1.2.1.58 -- phenylglyoxylate dehydrogenase (acylating) ,
1.2.1.59 -- glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) ,
1.2.1.60 -- 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase ,
1.2.1.61 -- 4-hydroxymuconic-semialdehyde dehydrogenase ,
1.2.1.62 -- 4-formylbenzenesulfonate dehydrogenase ,
1.2.1.63 -- 6-oxohexanoate dehydrogenase ,
1.2.1.64 -- 4-hydroxybenzaldehyde dehydrogenase ,
1.2.1.65 -- salicylaldehyde dehydrogenase ,
1.2.1.67 -- vanillin dehydrogenase ,
1.2.1.68 -- coniferyl-aldehyde dehydrogenase ,
1.2.1.69 -- fluoroacetaldehyde dehydrogenase ,
1.2.1.70 -- glutamyl-tRNA reductase ,
1.2.1.71 -- succinylglutamate-semialdehyde dehydrogenase ,
1.2.1.72 -- erythrose-4-phosphate dehydrogenase ,
1.2.1.73 -- sulfoacetaldehyde dehydrogenase ,
1.2.1.74 -- abieta-7,13-dien-18-al dehydrogenase ,
1.2.1.75 -- malonyl-CoA reductase (malonate semialdehyde-forming) ,
1.2.1.76 -- succinate-semialdehyde dehydrogenase (acylating) ,
1.2.1.77 -- 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP+) ,
1.2.1.78 -- 2-formylbenzoate dehydrogenase ,
1.2.1.79 -- succinate-semialdehyde dehydrogenase (NADP+) ,
1.2.1.80 -- long-chain acyl-[acyl-carrier-protein] reductase ,
1.2.1.81 -- sulfoacetaldehyde dehydrogenase (acylating) ,
1.2.1.82 -- β-apo-4′-carotenal oxygenase ,
1.2.1.83 -- 3-succinoylsemialdehyde-pyridine dehydrogenase ,
1.2.1.84 -- alcohol-forming fatty acyl-CoA reductase ,
1.2.1.85 -- 2-hydroxymuconate-6-semialdehyde dehydrogenase ,
1.2.1.86 -- geranial dehydrogenase ,
1.2.1.87 -- propanal dehydrogenase (CoA-propanoylating) ,
1.2.1.88 -- L-glutamate γ-semialdehyde dehydrogenase ,
1.2.1.89 -- D-glyceraldehyde dehydrogenase (NADP+) ,
1.2.1.90 -- glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] ,
1.2.1.91 -- 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase ,
1.2.1.92 -- 3,6-anhydro-α-L-galactose dehydrogenase

Unofficial Reactions:
a very long chain alcohol + coenzyme A + 2 NADP+ ← a very long chain fatty acyl-CoA + 2 NADPH + 2 H+ ,
indole-3-glycol aldehyde + an oxidized unknown electron acceptor + H2O → indole-3-glycolate + an reduced unknown electron acceptor + H+ ,
(S)-2-amino-6-oxohexanoate + NAD+ + H2O = L-2-aminoadipate + NADH + 2 H+ ,
4-(γ-glutamylamino)butanal + NAD(P)+ + H2O → 4-(γ-L-glutamylamino)butanoate + NAD(P)H + 2 H+ ,
a long-chain aldehyde + coenzyme A + NAD+ ← a long-chain acyl-CoA + NADH + H+ ,
an ω-oxo fatty acid + NAD+ + H2O → an α,ω-dicarboxylate + NADH + 2 H+ ,
4-hydroxybenzaldehyde + NAD(P)+ + H2O → 4-hydroxybenzoate + NAD(P)H + 2 H+ ,
bixin aldehyde + 2 NAD+ + 2 H2O → norbixin + 2 NADH + 4 H+ ,
3-oxo-24-ethyl-26-al-cholest-4-ene + NAD+ + H2O → 3-oxo-24-ethyl-cholest-4-en-26-oate + NADH + 2 H+ ,
chloroacetaldehyde + NAD+ + H2O ↔ chloroacetate + NADH + 2 H+ ,
18-oxo-oleoyl-CoA + NADP+ + H2O = ω-carboxy-(9Z)-octadec-9-enoyl-CoA + NADPH + 2 H+ ,
3-aminopropanal + NAD+ + H2O = β-alanine + NADH + 2 H+ ,
4-carboxybenzaldehyde + NAD+ + H2O ↔ terephthalate + NADH + 2 H+ ,
gentisaldehyde + NADP+ + H2O → gentisate + NADPH + 2 H+ ,
(S)-lactaldehyde + NADP+ + H2O → (S)-lactate + NADPH + 2 H+ ,
L-4-hydroxyglutamate semialdehyde + NAD+ + H2O → erythro-4-hydroxy-L-glutamate + NADH + 2 H+ ,
18-oxo-oleate + NADP+ + H2O → α,ω-9Z-octadecenedioate + NADPH + 2 H+ ,
a [LysW]-C-terminal-L-glutamyl-γ-L-2-aminoadipate 6-phosphate + NADPH + H+ → a [LysW]-C-terminal-L-glutamyl-γ-L-2-aminoadipate semialdehyde + NADP+ + phosphate ,
3-hydroxypropionaldehyde + NAD+ + H2O → 3-hydroxypropanoate + NADH + 2 H+ ,
a long-chain aldehyde + NADH + H+ → a long-chain alcohol + NAD+ ,
22-oxo-docosanoyl-CoA + NADP+ + H2O → 22-carboxy-docosanoyl-CoA + NADPH + 2 H+ ,
apo-4'-lycopenal + NAD(P)+ + H2O → apo-4'-lycopenoate + NADPH + H+ ,
(25S)-3-oxocholest-4-en-26-al + NAD+ + H2O → (25S)-3-oxocholest-4-en-26-oate + NADH + 2 H+ ,
(15Z)-tetracos-15-enal + coenzyme A + NAD+ ← (Z)-15-tetracosenoyl-CoA + NADH + H+ ,
3-aminopropanal + NAD(P)+ + H2O → β-alanine + NAD(P)H + 2 H+ ,
(10E,12Z)-10,12-hexadecadienoate + 2 NADPH + 3 H+ → bombykol + 2 NADP+ + H2O ,
phosphonoacetaldehyde + NAD+ + H2O → phosphonoacetate + NADH + 2 H+ ,
2,5-dioxopentanoate + NAD(P)+ + H2O → 2-oxoglutarate + NAD(P)H + 2 H+ ,
4-guanidinobutyraldehyde + an oxidized unknown electron acceptor + H2O → 4-guanidinobutanoate + an reduced unknown electron acceptor + H+ ,
glutarate semialdehyde + NADP+ + H2O → glutarate + NADPH + 2 H+ ,
3-oxopropanoate + coenzyme A + NADP+ = acetyl-CoA + CO2 + NADPH ,
hexanal + coenzyme A + NAD(P)+ ← hexanoyl-CoA + NAD(P)H + H+ ,
1-piperideine 6-carboxylate + NAD+ + 2 H2O → L-2-aminoadipate + NADH + H+ ,
3-oxopropanoate + coenzyme A + NAD+ → acetyl-CoA + CO2 + NADH ,
glycolaldehyde + an oxidized unknown electron acceptor → glycolate + an reduced unknown electron acceptor + H+ ,
1-pyrroline + NAD+ + 2 H2O = 4-aminobutanoate + NADH + 2 H+ ,
16-oxo-palmitate + NADP+ + H2O → hexadecanedioate + NADPH + 2 H+ ,
sinapaldehyde + NADP+ + H2O → sinapate + NADPH + 2 H+ ,
indole-3-glyoxal + an oxidized unknown electron acceptor + H2O → indole-3-glyoxylate + an reduced unknown electron acceptor + H+ ,
4-aminobutanal + NADP+ + H2O = 4-aminobutanoate + NADPH + 2 H+ ,
(8E,10E)-dodeca-8,10-dienoate + 2 NADPH + 3 H+ = (8E,10E)-dodeca-8,10-dienol + 2 NADP+ + H2O ,
4-methyl-2-oxopentanoate + coenzyme A + NAD+ → isovaleryl-CoA + CO2 + NADH ,
pyruvate + coenzyme A + NAD+ ↔ acetyl-CoA + CO2 + NADH ,
(S)-3-methyl-2-oxopentanoate + coenzyme A + NAD+ ↔ 2-methylbutanoyl-CoA + CO2 + NADH

Enzymes and Genes:
pyruvate dehydrogenase : lpd , aceE , aceF
pyruvate dehydrogenase complex : pdhB , Synpcc7942_1944 , pdhC , pdhD ( Synechococcus elongatus PCC 7942 )
pyruvate dehydrogenase complex : DLD , AF123459 , DLAT , PDHA1 , PDHB ( Ascaris suum )
pyruvate dehydrogenase complex : PDHA1 , PDHB , DLAT , PDHX , DLD ( Homo sapiens )
pyruvate dehydrogenase complex ( Crithidia fasciculata )
pyruvate dehydrogenase complex ( Pisum sativum )
pyruvate dehydrogenase complex : pdhB , pdhA , pdhC , pdhD ( Mycoplasma pneumoniae M129 )
branched-chain α-keto acid dehydrogenase complex : BCKDHB , BCKDHA , DBT , DLD ( Homo sapiens )
branched-chain α-keto acid dehydrogenase complex : bfmBAB , bfmBAA , bfmBB , pdhD ( Bacillus subtilis )
hydroxycinnamaldehyde dehydrogenase : REF1 ( Arabidopsis thaliana col )
glycolaldehyde oxidoreductase : SSO2637 , SSO2636 , SSO2639 ( Sulfolobus solfataricus P2 )
malonate semialdehyde dehydrogenase (CoA-acylating) : ALD6 ( Candida albicans SC5314 )
(methyl)malonate-semialdehyde dehydrogenase : mmsA ( Bacillus subtilis subtilis 168 )
malonate-semialdehyde dehydrogenase ( Enterobacter aerogenes )
malonate semialdehyde dehydrogenase ( Pseudomonas fluorescens )
malonate semialdehyde dehydrogenase ( Rattus norvegicus )
aldehyde/alcohol dehydrogenase : adhE2 ( Clostridium acetobutylicum )
malonate-semialdehyde dehydrogenase (acetylating) : dddC ( Halomonas sp. HTNK1 )
glutarate semialdehyde dehydrogenase : PA0265 ( Pseudomonas aeruginosa )
glutarate semialdehyde dehydrogenase : davD ( Pseudomonas putida )
2-ketoglutarate semialdehyde dehydrogenase : PA2217 ( Pseudomonas aeruginosa PAO1 )
α-ketoglutaric semialdehyde dehydrogenase : araE ( Azospirillum brasilense )
phosphonoacetaldehyde dehydrogenase : phnY ( Sinorhizobium meliloti 1021 )
pheromone gland-specific fatty-acyl reductase : FAR ( Bombyx mori )
cholest-4-en-3-one 26-monooxygenase : cyp125 ( Mycobacterium tuberculosis )
cholest-4-en-3-one 26-monooxygenase : cyp125 ( Rhodococcus jostii RHA1 )
apo-4'-lycopenal dehydrogenase : YLO-1 ( Neurospora crassa )
[LysW]-L-2-aminoadipate/[LysW]-L-glutamate phosphate reductase : lysY ( Sulfolobus acidocaldarius )
[LysW]-L-2-aminoadipate 6-phosphate reductase : lysY ( Thermus thermophilus )
Δ1-pyrroline-5-carboxylate dehydrogenase, mitochondrial : ALDH4A1 ( Homo sapiens )
Δ1-pyrroline-5-carboxylate dehydrogenase ( Bos taurus )
NAD(P)+ L-lactaldehyde dehydrogenase : LADH ( Scheffersomyces stipitis CBS 6054 )
aldehyde dehydrogenase, mitochondrial : ALD5 ( Saccharomyces cerevisiae )
potassium-activated aldehyde dehydrogenase, mitochondrial : ALD4 ( Saccharomyces cerevisiae )
NADPH-dependent aldehyde reductase : yqhD ( Escherichia coli K-12 substr. MG1655 )
4-carboxybenzaldehyde dehydrogenase / 4-sulfobenzaldehyde dehydrogenase : tsaD ( Comamonas testosteroni T-2 )
betaine aldehyde / aminoaldehyde dehydrogenase : ALDH10A9 ( Arabidopsis thaliana col )
3-aminopropionaldehyde dehydrogenase ( Setaria italica )
aminopropionaldehyde dehydrogenase ( Arthrobacter sp. TMP-1 )
aldehyde dehydrogenase : ALD2 ( Saccharomyces cerevisiae )
aldehyde dehydrogenase : ALD3 ( Saccharomyces cerevisiae )
chloroacetaldehyde dehydrogenase ( Xanthobacter autotrophicus )
bixin aldehyde dehydrogenase : BADH ( Bixa orellana )
acyl-CoA reductase (NADH) : U80676 ( Botryococcus braunii BOT88-2 )
γ-glutamyl-γ-aminobutyraldehyde dehydrogenase : puuC ( Escherichia coli K-12 substr. MG1655 )
Δ1-piperideine-6-carboxylate dehydrogenase : pcd ( [Flavobacterium] lutescens )
Δ1-piperideine-6-carboxylate dehydrogenase : pcd ( Streptomyces clavuligerus )
L-α-aminoadipate δ-semialdehyde:NAD oxidoreductase : amaA ( Pseudomonas putida )
α-aminoadipic semialdehyde dehydrogenase : ALDH7A1 ( Homo sapiens )
alcohol-forming fatty acyl-CoA reductase : CER4 ( Arabidopsis thaliana col )


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Tue Jun 30, 2015, BIOCYC14A.