Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
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for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc EC 1.14.11 -- With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

Parent Class: EC-Numbers 1 -- Oxidoreductases 1.14 -- Acting on paired donors, with incorporation or reduction of molecular oxygen

Instances:
1.14.11.1 -- γ-butyrobetaine dioxygenase ,
1.14.11.2 -- procollagen-proline dioxygenase ,
1.14.11.3 -- pyrimidine-deoxynucleoside 2′-dioxygenase ,
1.14.11.4 -- procollagen-lysine 5-dioxygenase ,
1.14.11.6 -- thymine dioxygenase ,
1.14.11.7 -- procollagen-proline 3-dioxygenase ,
1.14.11.8 -- trimethyllysine dioxygenase ,
1.14.11.9 -- flavanone 3-dioxygenase ,
1.14.11.10 -- pyrimidine-deoxynucleoside 1′-dioxygenase ,
1.14.11.11 -- hyoscyamine (6S)-dioxygenase ,
1.14.11.12 -- gibberellin-44 dioxygenase ,
1.14.11.13 -- gibberellin 2β-dioxygenase ,
1.14.11.14 -- 6β-hydroxyhyoscyamine epoxidase ,
1.14.11.15 -- gibberellin 3β-dioxygenase ,
1.14.11.16 -- peptide-aspartate β-dioxygenase ,
1.14.11.17 -- taurine dioxygenase ,
1.14.11.18 -- phytanoyl-CoA dioxygenase ,
1.14.11.19 -- leucocyanidin oxygenase ,
1.14.11.20 -- deacetoxyvindoline 4-hydroxylase ,
1.14.11.21 -- clavaminate synthase ,
1.14.11.22 -- flavone synthase ,
1.14.11.23 -- flavonol synthase ,
1.14.11.24 -- 2′-deoxymugineic-acid 2′-dioxygenase ,
1.14.11.25 -- mugineic-acid 3-dioxygenase ,
1.14.11.26 -- deacetoxycephalosporin-C hydroxylase ,
1.14.11.27 -- [histone-H3]-lysine-36 demethylase ,
1.14.11.28 -- proline 3-hydroxylase ,
1.14.11.29 -- hypoxia-inducible factor-proline dioxygenase ,
1.14.11.30 -- hypoxia-inducible factor-asparagine dioxygenase ,
1.14.11.31 -- thebaine 6-O-demethylase ,
1.14.11.32 -- codeine 3-O-demethylase ,
1.14.11.33 -- DNA oxidative demethylase ,
1.14.11.34 -- 2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming) ,
1.14.11.35 -- 1-deoxypentalenic acid 11β-hydroxylase ,
1.14.11.36 -- pentalenolactone F synthase ,
1.14.11.37 -- kanamycin B dioxygenase ,
1.14.11.38 -- verruculogen synthase ,
1.14.11.39 -- L-asparagine hydroxylase ,
1.14.11.40 -- enduracididine β-hydroxylase ,
1.14.11.41 -- L-arginine hydroxylase ,
1.14.11.42 -- tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase ,
1.14.11.43 -- (S)-dichlorprop dioxygenase (2-oxoglutarate) ,
1.14.11.44 -- (R)-dichlorprop dioxygenase (2-oxoglutarate) ,
1.14.11.45 -- L-isoleucine 4-hydroxylase ,
1.14.11.46 -- 2-aminoethylphosphonate dioxygenase ,
1.14.11.u -- xanthine dioxygenase

Unofficial Reactions:
leucopelargonidin + 2-oxoglutarate + oxygen → pelargonidin + succinate + CO2 + H+ + 2 H2O ,
gibberellin A20 + 2-oxoglutarate + oxygen → gibberellin A29 + succinate + CO2 ,
gibberellin A29 + 2-oxoglutarate + oxygen → gibberellin A29-catabolite + succinate + CO2 + H+ + H2O ,
gibberellin A8 + 2-oxoglutarate + oxygen → gibberellin A8-catabolite + succinate + CO2 + H+ + H2O ,
2-hydroxyethylphosphonate + 2-oxoglutarate + oxygen → 1,2-dihydroxyethylphosphonate + succinate + CO2 ,
feruloyl-CoA + 2-oxoglutarate + oxygen → 6'-hydroxyferuloyl-CoA + succinate + CO2 ,
3 2-oxoglutarate + L-arginine + 3 oxygen + 3 H+ → 2 ethylene + 7 CO2 + succinate + guanidinium + (S)-1-pyrroline-5-carboxylate + 3 H2O ,
L-arginine + 2-oxoglutarate + oxygen → Nω-hydroxy-L-arginine + succinate + CO2 ,
pentalenolactone E + 2-oxoglutarate + oxygen → pentalenolactone F + succinate + CO2 ,
pentalenolactone D + 2-oxoglutarate + oxygen → pentalenolactone E + succinate + CO2 + H2O ,
neopentalenolactone D + 2-oxoglutarate + oxygen → neopentalenolactone E + succinate + CO2 + H2O ,
neopentalenolactone E + 2-oxoglutarate + oxygen → neopentalenolactone F + succinate + CO2 ,
4-coumaryl-CoA + 2-oxoglutarate + oxygen → 2,4-dihydroxycinnamoyl-CoA + succinate + CO2 ,
L-leucine + 2-oxoglutarate + oxygen → 4-hydroxy-L-leucine + succinate + CO2 ,
L-methionine + 2-oxoglutarate + oxygen → L-methionine S-oxide + succinate + CO2 ,
L-threonine + 2-oxoglutarate + oxygen → 4-hydroxy-L-threonine + succinate + CO2 ,
3,7-dimethylquercetin + 2-oxoglutarate + oxygen → 3,7-dimethylquercetagetin + succinate + CO2 ,
3,7,4'-trimethylquercetin + 2-oxoglutarate + oxygen → 3,7,4'-trimethylquercetagetin + succinate + CO2 ,
L-proline + 2-oxoglutarate + oxygen → cis-4-hydroxy-L-proline + succinate + CO2 ,
gibberellin A20 + a reduced electron acceptor + oxygen → gibberellin A5 + an oxidized electron acceptor + 2 H2O ,
gibberellin A5 + 2-oxoglutarate + oxygen → gibberellin A3 + succinate + CO2 ,
gibberellin A5 + 2-oxoglutarate + oxygen → gibberellin A6 + succinate + CO2 ,
UMP + 2-oxoglutarate + oxygen → uridine-5'-aldehyde + succinate + CO2 + phosphate ,
luteoforol + 2-oxoglutarate + oxygen + H+ → luteolinidin + succinate + CO2 + 2 H2O ,
apiforol + 2-oxoglutarate + oxygen → apigeninidin + succinate + CO2 + 2 H2O ,
gardenin B + 2-oxoglutarate + oxygen → nevadensin + formaldehyde + succinate + CO2 ,
8-hydroxy-salvigenin + 2-oxoglutarate + oxygen → pilosin + formaldehyde + succinate + CO2 ,
FR-900098 + 2-oxoglutarate + oxygen → FR-33289 + succinate + CO2 ,
fusicocca-2,10(14)-diene-8β,16-diol + 2-oxoglutarate + oxygen → fusicocca-1,10(14)-diene-3,8β,16-triol + succinate + CO2 ,
fusicocca-2,10(14)-diene-8β,16-diol + 2-oxoglutarate + oxygen → 8β-hydroxyfusicocca-1,10(14)-diene-16-al + succinate + CO2 + H2O ,
gibberellin A9 + 2-oxoglutarate + oxygen → gibberellin A51 + succinate + CO2 ,
gibberellin A51 + 2-oxoglutarate + oxygen → gibberellin A51-catabolite + succinate + CO2 + H+ + H2O ,
gibberellin A34 + 2-oxoglutarate + oxygen → gibberellin A34-catabolite + succinate + CO2 + H+ + H2O ,
gibberellin A15 (open lactone form) + 2-oxoglutarate + oxygen → gibberellin A37 + succinate + CO2 ,
gibberellin A24 + 2-oxoglutarate + oxygen → gibberellin A36 + succinate + CO2 ,
gibberellin44 (open lactone form) + 2-oxoglutarate + H+ + oxygen → gibberellin A38 + succinate + CO2 + H2O ,
gibberellin A25 + 2-oxoglutarate + oxygen → gibberellin A13 + succinate + CO2 ,
gibberellin A13 + 2-oxoglutarate + oxygen → gibberellin A43 + succinate + CO2 ,
gibberellin A25 + 2-oxoglutarate + oxygen → gibberellin A46 + succinate + CO2 ,
gibberellin A12 + 2-oxoglutarate + oxygen → gibberellin A14 + succinate + CO2 ,
gibberellin A12-aldehyde + NADPH + H+ + oxygen → gibberellin A14-aldehyde + NADP+ + H2O ,
gibberellin A17 + 2-oxoglutarate + oxygen → gibberellin A28 + succinate + CO2 ,
gibberellin A28 + 2-oxoglutarate + oxygen → (2βOH)-gibberellin28 + succinate + CO2 ,
gibberellin A14-aldehyde + NADPH + oxygen → gibberellin A14 + NADP+ + H2O ,
gibberellin A4 + 2-oxoglutarate + oxygen → gibberellin A34 + succinate + CO2 ,
gibberellin A14 + 2-oxoglutarate + oxygen → gibberellin A37 + CO2 + succinate ,
gibberellin A37 + 2-oxoglutarate + oxygen → gibberellin A36 + succinate + CO2 + H2O ,
gibberellin A36 + 2-oxoglutarate + oxygen → gibberellin A4 + succinate + 2 CO2 + H+ ,
gibberellin A7 + NADPH + H+ + oxygen → gibberellin A3 + NADP+ + H2O ,
gibberellin A9 + a reduced electron acceptor + oxygen → gibberellin A40 + an oxidized electron acceptor + H2O ,
gibberellin A15 (closed lactone form) + 2-oxoglutarate + oxygen → gibberellin A37 (closed lactone form) + succinate + CO2 ,
leucodelphinidin + 2-oxoglutarate + oxygen → delphinidin + CO2 + succinate + H+ + 2 H2O ,
a [protein] N6-methyl-L-lysine + 2-oxoglutarate + oxygen + H+ → a [protein]-L-lysine + succinate + formaldehyde + CO2 ,
gibberellin A44 (closed lactone form) + 2-oxoglutarate + 2 H+ + oxygen → gibberellin A98 + succinate + CO2 ,
gibberellin A12 + 2-oxoglutarate + oxygen → gibberellin A110 + succinate + CO2 ,
2,4-dichlorophenoxyacetate + 2-oxoglutarate + oxygen → 2,4-dichlorophenol + glyoxylate + succinate + CO2 ,
4-chloro-2-methylphenoxyacetate + 2-oxoglutarate + oxygen → 2-methyl-4-chlorophenol + glyoxylate + succinate + CO2 ,
2-chloro-4-methyl-phenoxyacetate + 2-oxoglutarate + oxygen → 2-chloro-4-methylphenol + glyoxylate + succinate + CO2 ,
gibberellin A53 + 2-oxoglutarate + oxygen → gibberellin A97 + succinate + CO2 ,
gibberellin A19 + 2-oxoglutarate + oxygen → gibberellin A17 + succinate + CO2 + H+ ,
gibberellin A12 + 2-oxoglutarate + oxygen → gibberellin A15 (open lactone form) + CO2 + succinate ,
gibberellin A15 (open lactone form) + 2-oxoglutarate + oxygen → gibberellin A24 + succinate + CO2 + H2O ,
gibberellin A24 + 2-oxoglutarate + oxygen → gibberellin A9 + 2 CO2 + succinate + H+ ,
gibberellin A9 + 2-oxoglutarate + oxygen → gibberellin A4 + succinate + CO2 ,
gibberellin A4 + NADPH + H+ + oxygen → gibberellin A1 + NADP+ + H2O ,
gibberellin A53 + 2-oxoglutarate + oxygen → gibberellin44 (open lactone form) + CO2 + succinate ,
gibberellin A19 + 2-oxoglutarate + oxygen → gibberellin A20 + 2 CO2 + succinate + H+ ,
gibberellin A24 + 2-oxoglutarate + oxygen → gibberellin A25 + CO2 + succinate + H+ ,
L-proline + 2-oxoglutarate + oxygen → trans-4-hydroxy-L-proline + succinate + CO2 ,
a 3-methyl-branched 2,3,4-saturated fatty acyl-CoA + 2-oxoglutarate + oxygen → a 2-hydroxy-3-methyl-branched 2,3,4-saturated fatty acyl-CoA + succinate + CO2

Enzymes and Genes:
phytanoyl-CoA dioxygenase, peroxisomal : Phyh ( Rattus norvegicus )
phytanoyl-CoA dioxygenase, peroxisomal : PHYH ( Homo sapiens )
proline 4-hydroxylase : D78338 ( Dactylosporangium sp. strain RH1 )
gibberellin 20-oxidase : SD1 ( Oryza sativa )
gibberellin 3-oxidase : GA3ox2 ( Arabidopsis thaliana col )
gibberellin 3-oxidase : GA3ox3 ( Cucurbita maxima )
gibberellin 3-oxidase : GA3ox1 ( Spinacia oleracea )
gibberellin 3-oxidase : GA3ox1 ( Phaseolus coccineus )
gibberellin 20-oxidase : GA20ox4 ( Arabidopsis thaliana col )
gibberellin 20-oxidase : GA20ox1D ( Triticum aestivum )
gibberellin 20-oxidase : GA20ox3 ( Arabidopsis thaliana col )
gibberellin 20-oxidase : GA20ox2 ( Arabidopsis thaliana col )
gibberellin 20-oxidase : GA20ox ( Pisum sativum )
gibberellin 20-oxidase : GA20ox ( Cucurbita maxima )
2,4-dichlorophenoxyacetate dioxygenase : tfdA ( Ralstonia eutropha JMP134 )
gibberellin 2-oxidase : GA2ox3 ( Spinacia oleracea )
gibberellin 2-oxidase : GA2ox8 ( Arabidopsis thaliana col )
gibberellin 2-oxidase : GA2ox7 ( Arabidopsis thaliana col )
anthocyanidin synthase : ans ( Vaccinium myrtillus )
gibberellin 2α-hydroxylase / gibberellin 1,2-desaturase : DES ( Fusarium fujikuroi )
gibberellin 13-hydroxylase : P450-3 ( Fusarium fujikuroi )
gibberellin 20-oxidase : GA20ox2 ( Cucurbita maxima )
gibberellin 20-oxidase : GA20ox1 ( Arabidopsis thaliana col )
gibberellin 3β-hydroxylase / ent-kaurenoate oxidase : P450-1 ( Fusarium fujikuroi )
gibberellin 3-oxidase : GA3ox1 ( Arabidopsis thaliana col )
gibberellin 2β,3β-hydroxylase : GA3ox1 ( Cucurbita maxima )
fusicocca-2,10(14)-diene-8β,16-diol dioxygenase : fc-dox ( Diaporthe amygdali )
fusicocca-2,10(14)-diene-8β,16-diol dioxygenase : bc-dox ( Alternaria brassicicola ATCC 96836 )
FR-33289 synthase : frbJ ( Streptomyces rubellomurinus )
gardenin B 7-O-demethylase / 8-hydroxy-salvigenin 7-O-demethylase ( Ocimum basilicum )
uridine-5'-monophosphate:2-oxoglutarate dioxygenase : lipL ( Streptomyces sp. SANK 60405 )
gibberellin 3-oxidase (multifunctional) : GA3ox2-1 ( Triticum aestivum )
gibberellin 2β,3β-hydroxylase : GA3ox1 ( Oryza sativa )
flavonol 6-hydroxylase : F6H ( Chrysosplenium americanum )
L-threonine 4-hydroxylase : tdo ( Bordetella petrii DSM 12804 )
L-isoleucine-4-hydroxylase : ido ( Bacillus thuringiensis )
neopentalenolactone D dioxygenase : ptlD ( Streptomyces avermitilis )
pentalenolactone D dioxygenase : penD ( Streptomyces exfoliatus )
L-arginine Nω-oxidase : dcsA ( Streptomyces lavendulae lavendulae )
4-coumaroyl 2'-hydroxylase : C2'H ( Ipomoea batatas )
4-coumaroyl 2'-hydroxylase : CYP98A22 ( Ruta graveolens )
feruloyl-CoA 6'-hydroxylase : At3G13610 ( Arabidopsis thaliana col )
2-hydroxyethylphosphonate 1-hydroxylase : dhpA ( Streptomyces luridus )
gibberellin 2-oxidase : GA2ox1 ( Pisum sativum )
gibberellin 2-oxidase : GA2ox2 ( Spinacia oleracea )
gibberellin 2-oxidase : GA2ox1 ( Phaseolus coccineus )
gibberellin 2-oxidase : GA2ox1 ( Spinacia oleracea )
gibberellin 2-oxidase : GA2ox3 ( Oryza sativa )
gibberellin 2-oxidase : GA2ox1 ( Oryza sativa )
gibberellin 2-oxidase : GA2ox3 ( Arabidopsis thaliana col )
gibberellin 2-oxidase : GA2ox2 ( Arabidopsis thaliana col )
gibberellin 2-oxidase : GA2ox1 ( Arabidopsis thaliana col )
anthocyanidin synthase : AT4g22880 ( Arabidopsis thaliana col )
anthocyanidin synthase ( Glycine max )


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Dec 20, 2014, biocyc11.