Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc EC 1.14.11 -- With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

Parent Class: EC-Numbers 1 -- Oxidoreductases 1.14 -- Acting on paired donors, with incorporation or reduction of molecular oxygen

Instances:
1.14.11.1 -- γ-butyrobetaine dioxygenase ,
1.14.11.2 -- procollagen-proline dioxygenase ,
1.14.11.3 -- pyrimidine-deoxynucleoside 2′-dioxygenase ,
1.14.11.4 -- procollagen-lysine 5-dioxygenase ,
1.14.11.6 -- thymine dioxygenase ,
1.14.11.7 -- procollagen-proline 3-dioxygenase ,
1.14.11.8 -- trimethyllysine dioxygenase ,
1.14.11.9 -- flavanone 3-dioxygenase ,
1.14.11.10 -- pyrimidine-deoxynucleoside 1′-dioxygenase ,
1.14.11.11 -- hyoscyamine (6S)-dioxygenase ,
1.14.11.12 -- gibberellin-44 dioxygenase ,
1.14.11.13 -- gibberellin 2β-dioxygenase ,
1.14.11.14 -- 6β-hydroxyhyoscyamine epoxidase ,
1.14.11.15 -- gibberellin 3β-dioxygenase ,
1.14.11.16 -- peptide-aspartate β-dioxygenase ,
1.14.11.17 -- taurine dioxygenase ,
1.14.11.18 -- phytanoyl-CoA dioxygenase ,
1.14.11.19 -- leucocyanidin oxygenase ,
1.14.11.20 -- deacetoxyvindoline 4-hydroxylase ,
1.14.11.21 -- clavaminate synthase ,
1.14.11.22 -- flavone synthase ,
1.14.11.23 -- flavonol synthase ,
1.14.11.24 -- 2′-deoxymugineic-acid 2′-dioxygenase ,
1.14.11.25 -- mugineic-acid 3-dioxygenase ,
1.14.11.26 -- deacetoxycephalosporin-C hydroxylase ,
1.14.11.27 -- [histone-H3]-lysine-36 demethylase ,
1.14.11.28 -- proline 3-hydroxylase ,
1.14.11.29 -- hypoxia-inducible factor-proline dioxygenase ,
1.14.11.30 -- hypoxia-inducible factor-asparagine dioxygenase ,
1.14.11.31 -- thebaine 6-O-demethylase ,
1.14.11.32 -- codeine 3-O-demethylase ,
1.14.11.33 -- DNA oxidative demethylase ,
1.14.11.34 -- 2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming) ,
1.14.11.35 -- 1-deoxypentalenic acid 11β-hydroxylase ,
1.14.11.36 -- pentalenolactone F synthase ,
1.14.11.37 -- kanamycin B dioxygenase ,
1.14.11.38 -- verruculogen synthase ,
1.14.11.39 -- L-asparagine hydroxylase ,
1.14.11.40 -- enduracididine β-hydroxylase ,
1.14.11.41 -- L-arginine hydroxylase ,
1.14.11.42 -- tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase ,
1.14.11.43 -- (S)-dichlorprop dioxygenase (2-oxoglutarate) ,
1.14.11.44 -- (R)-dichlorprop dioxygenase (2-oxoglutarate) ,
1.14.11.45 -- L-isoleucine 4-hydroxylase ,
1.14.11.46 -- 2-aminoethylphosphonate dioxygenase ,
1.14.11.u -- xanthine dioxygenase

Unofficial Reactions:
leucopelargonidin + 2-oxoglutarate + oxygen → pelargonidin + succinate + CO2 + H+ + 2 H2O ,
gibberellin A20 + 2-oxoglutarate + oxygen → gibberellin A29 + succinate + CO2 ,
gibberellin A29 + 2-oxoglutarate + oxygen → gibberellin A29-catabolite + succinate + CO2 + H+ + H2O ,
gibberellin A8 + 2-oxoglutarate + oxygen → gibberellin A8-catabolite + succinate + CO2 + H+ + H2O ,
2-hydroxyethylphosphonate + 2-oxoglutarate + oxygen → 1,2-dihydroxyethylphosphonate + succinate + CO2 ,
feruloyl-CoA + 2-oxoglutarate + oxygen → 6'-hydroxyferuloyl-CoA + succinate + CO2 ,
3 2-oxoglutarate + L-arginine + 3 oxygen + 3 H+ → 2 ethylene + 7 CO2 + succinate + guanidinium + (S)-1-pyrroline-5-carboxylate + 3 H2O ,
L-arginine + 2-oxoglutarate + oxygen → Nω-hydroxy-L-arginine + succinate + CO2 ,
pentalenolactone E + 2-oxoglutarate + oxygen → pentalenolactone F + succinate + CO2 ,
pentalenolactone D + 2-oxoglutarate + oxygen → pentalenolactone E + succinate + CO2 + H2O ,
neopentalenolactone D + 2-oxoglutarate + oxygen → neopentalenolactone E + succinate + CO2 + H2O ,
neopentalenolactone E + 2-oxoglutarate + oxygen → neopentalenolactone F + succinate + CO2 ,
4-coumaryl-CoA + 2-oxoglutarate + oxygen → 2,4-dihydroxycinnamoyl-CoA + succinate + CO2 ,
L-leucine + 2-oxoglutarate + oxygen → 4-hydroxy-L-leucine + succinate + CO2 ,
L-methionine + 2-oxoglutarate + oxygen → L-methionine S-oxide + succinate + CO2 ,
L-threonine + 2-oxoglutarate + oxygen → 4-hydroxy-L-threonine + succinate + CO2 ,
3,7-dimethylquercetin + 2-oxoglutarate + oxygen → 3,7-dimethylquercetagetin + succinate + CO2 ,
3,7,4'-trimethylquercetin + 2-oxoglutarate + oxygen → 3,7,4'-trimethylquercetagetin + succinate + CO2 ,
L-proline + 2-oxoglutarate + oxygen → cis-4-hydroxy-L-proline + succinate + CO2 ,
gibberellin A20 + a reduced electron acceptor + oxygen → gibberellin A5 + an oxidized electron acceptor + 2 H2O ,
gibberellin A5 + 2-oxoglutarate + oxygen → gibberellin A3 + succinate + CO2 ,
gibberellin A5 + 2-oxoglutarate + oxygen → gibberellin A6 + succinate + CO2 ,
UMP + 2-oxoglutarate + oxygen → uridine-5'-aldehyde + succinate + CO2 + phosphate ,
luteoforol + 2-oxoglutarate + oxygen + H+ → luteolinidin + succinate + CO2 + 2 H2O ,
apiforol + 2-oxoglutarate + oxygen → apigeninidin + succinate + CO2 + 2 H2O ,
gardenin B + 2-oxoglutarate + oxygen → nevadensin + formaldehyde + succinate + CO2 ,
8-hydroxy-salvigenin + 2-oxoglutarate + oxygen → pilosin + formaldehyde + succinate + CO2 ,
FR-900098 + 2-oxoglutarate + oxygen → FR-33289 + succinate + CO2 ,
fusicocca-2,10(14)-diene-8β,16-diol + 2-oxoglutarate + oxygen → fusicocca-1,10(14)-diene-3,8β,16-triol + succinate + CO2 ,
fusicocca-2,10(14)-diene-8β,16-diol + 2-oxoglutarate + oxygen → 8β-hydroxyfusicocca-1,10(14)-diene-16-al + succinate + CO2 + H2O ,
gibberellin A9 + 2-oxoglutarate + oxygen → gibberellin A51 + succinate + CO2 ,
gibberellin A51 + 2-oxoglutarate + oxygen → gibberellin A51-catabolite + succinate + CO2 + H+ + H2O ,
gibberellin A34 + 2-oxoglutarate + oxygen → gibberellin A34-catabolite + succinate + CO2 + H+ + H2O ,
gibberellin A15 (open lactone form) + 2-oxoglutarate + oxygen → gibberellin A37 + succinate + CO2 ,
gibberellin A24 + 2-oxoglutarate + oxygen → gibberellin A36 + succinate + CO2 ,
gibberellin44 (open lactone form) + 2-oxoglutarate + H+ + oxygen → gibberellin A38 + succinate + CO2 + H2O ,
gibberellin A25 + 2-oxoglutarate + oxygen → gibberellin A13 + succinate + CO2 ,
gibberellin A13 + 2-oxoglutarate + oxygen → gibberellin A43 + succinate + CO2 ,
gibberellin A25 + 2-oxoglutarate + oxygen → gibberellin A46 + succinate + CO2 ,
gibberellin A12 + 2-oxoglutarate + oxygen → gibberellin A14 + succinate + CO2 ,
gibberellin A12-aldehyde + NADPH + H+ + oxygen → gibberellin A14-aldehyde + NADP+ + H2O ,
gibberellin A17 + 2-oxoglutarate + oxygen → gibberellin A28 + succinate + CO2 ,
gibberellin A28 + 2-oxoglutarate + oxygen → (2βOH)-gibberellin28 + succinate + CO2 ,
gibberellin A14-aldehyde + NADPH + oxygen → gibberellin A14 + NADP+ + H2O ,
gibberellin A4 + 2-oxoglutarate + oxygen → gibberellin A34 + succinate + CO2 ,
gibberellin A14 + 2-oxoglutarate + oxygen → gibberellin A37 + CO2 + succinate ,
gibberellin A37 + 2-oxoglutarate + oxygen → gibberellin A36 + succinate + CO2 + H2O ,
gibberellin A36 + 2-oxoglutarate + oxygen → gibberellin A4 + succinate + 2 CO2 + H+ ,
gibberellin A7 + NADPH + H+ + oxygen → gibberellin A3 + NADP+ + H2O ,
gibberellin A9 + a reduced electron acceptor + oxygen → gibberellin A40 + an oxidized electron acceptor + H2O ,
gibberellin A15 (closed lactone form) + 2-oxoglutarate + oxygen → gibberellin A37 (closed lactone form) + succinate + CO2 ,
leucodelphinidin + 2-oxoglutarate + oxygen → delphinidin + CO2 + succinate + H+ + 2 H2O ,
a [protein] N6-methyl-L-lysine + 2-oxoglutarate + oxygen + H+ → a [protein]-L-lysine + succinate + formaldehyde + CO2 ,
gibberellin A44 (closed lactone form) + 2-oxoglutarate + 2 H+ + oxygen → gibberellin A98 + succinate + CO2 ,
gibberellin A12 + 2-oxoglutarate + oxygen → gibberellin A110 + succinate + CO2 ,
2,4-dichlorophenoxyacetate + 2-oxoglutarate + oxygen → 2,4-dichlorophenol + glyoxylate + succinate + CO2 ,
4-chloro-2-methylphenoxyacetate + 2-oxoglutarate + oxygen → 2-methyl-4-chlorophenol + glyoxylate + succinate + CO2 ,
2-chloro-4-methyl-phenoxyacetate + 2-oxoglutarate + oxygen → 2-chloro-4-methylphenol + glyoxylate + succinate + CO2 ,
gibberellin A53 + 2-oxoglutarate + oxygen → gibberellin A97 + succinate + CO2 ,
gibberellin A19 + 2-oxoglutarate + oxygen → gibberellin A17 + succinate + CO2 + H+ ,
gibberellin A12 + 2-oxoglutarate + oxygen → gibberellin A15 (open lactone form) + CO2 + succinate ,
gibberellin A15 (open lactone form) + 2-oxoglutarate + oxygen → gibberellin A24 + succinate + CO2 + H2O ,
gibberellin A24 + 2-oxoglutarate + oxygen → gibberellin A9 + 2 CO2 + succinate + H+ ,
gibberellin A9 + 2-oxoglutarate + oxygen → gibberellin A4 + succinate + CO2 ,
gibberellin A4 + NADPH + H+ + oxygen → gibberellin A1 + NADP+ + H2O ,
gibberellin A53 + 2-oxoglutarate + oxygen → gibberellin44 (open lactone form) + CO2 + succinate ,
gibberellin A19 + 2-oxoglutarate + oxygen → gibberellin A20 + 2 CO2 + succinate + H+ ,
gibberellin A24 + 2-oxoglutarate + oxygen → gibberellin A25 + CO2 + succinate + H+ ,
L-proline + 2-oxoglutarate + oxygen → trans-4-hydroxy-L-proline + succinate + CO2 ,
a 3-methyl-branched 2,3,4-saturated fatty acyl-CoA + 2-oxoglutarate + oxygen → a 2-hydroxy-3-methyl-branched 2,3,4-saturated fatty acyl-CoA + succinate + CO2

Enzymes and Genes:
phytanoyl-CoA dioxygenase, peroxisomal : Phyh ( Rattus norvegicus )
phytanoyl-CoA dioxygenase, peroxisomal : PHYH ( Homo sapiens )
proline 4-hydroxylase : D78338 ( Dactylosporangium sp. strain RH1 )
gibberellin 20-oxidase : SD1 ( Oryza sativa )
gibberellin 3-oxidase : GA3ox2 ( Arabidopsis thaliana col )
gibberellin 3-oxidase : GA3ox3 ( Cucurbita maxima )
gibberellin 3-oxidase : GA3ox1 ( Spinacia oleracea )
gibberellin 3-oxidase : GA3ox1 ( Phaseolus coccineus )
gibberellin 20-oxidase : GA20ox4 ( Arabidopsis thaliana col )
gibberellin 20-oxidase : GA20ox1D ( Triticum aestivum )
gibberellin 20-oxidase : GA20ox3 ( Arabidopsis thaliana col )
gibberellin 20-oxidase : GA20ox2 ( Arabidopsis thaliana col )
gibberellin 20-oxidase : GA20ox ( Pisum sativum )
gibberellin 20-oxidase : GA20ox ( Cucurbita maxima )
2,4-dichlorophenoxyacetate dioxygenase : tfdA ( Ralstonia eutropha JMP134 )
gibberellin 2-oxidase : GA2ox3 ( Spinacia oleracea )
gibberellin 2-oxidase : GA2ox8 ( Arabidopsis thaliana col )
gibberellin 2-oxidase : GA2ox7 ( Arabidopsis thaliana col )
anthocyanidin synthase : ans ( Vaccinium myrtillus )
gibberellin 2α-hydroxylase / gibberellin 1,2-desaturase : DES ( Fusarium fujikuroi )
gibberellin 13-hydroxylase : P450-3 ( Fusarium fujikuroi )
gibberellin 20-oxidase : GA20ox2 ( Cucurbita maxima )
gibberellin 20-oxidase : GA20ox1 ( Arabidopsis thaliana col )
gibberellin 3β-hydroxylase / ent-kaurenoate oxidase : P450-1 ( Fusarium fujikuroi )
gibberellin 3-oxidase : GA3ox1 ( Arabidopsis thaliana col )
gibberellin 2β,3β-hydroxylase : GA3ox1 ( Cucurbita maxima )
fusicocca-2,10(14)-diene-8β,16-diol dioxygenase : fc-dox ( Diaporthe amygdali )
fusicocca-2,10(14)-diene-8β,16-diol dioxygenase : bc-dox ( Alternaria brassicicola ATCC 96836 )
FR-33289 synthase : frbJ ( Streptomyces rubellomurinus )
gardenin B 7-O-demethylase / 8-hydroxy-salvigenin 7-O-demethylase ( Ocimum basilicum )
uridine-5'-monophosphate:2-oxoglutarate dioxygenase : lipL ( Streptomyces sp. SANK 60405 )
gibberellin 3-oxidase (multifunctional) : GA3ox2-1 ( Triticum aestivum )
gibberellin 2β,3β-hydroxylase : GA3ox1 ( Oryza sativa )
flavonol 6-hydroxylase : F6H ( Chrysosplenium americanum )
L-threonine 4-hydroxylase : tdo ( Bordetella petrii DSM 12804 )
L-isoleucine-4-hydroxylase : ido ( Bacillus thuringiensis )
neopentalenolactone D dioxygenase : ptlD ( Streptomyces avermitilis )
pentalenolactone D dioxygenase : penD ( Streptomyces exfoliatus )
L-arginine Nω-oxidase : dcsA ( Streptomyces lavendulae lavendulae )
4-coumaroyl 2'-hydroxylase : C2'H ( Ipomoea batatas )
4-coumaroyl 2'-hydroxylase : CYP98A22 ( Ruta graveolens )
feruloyl-CoA 6'-hydroxylase : At3G13610 ( Arabidopsis thaliana col )
2-hydroxyethylphosphonate 1-hydroxylase : dhpA ( Streptomyces luridus )
gibberellin 2-oxidase : GA2ox1 ( Pisum sativum )
gibberellin 2-oxidase : GA2ox2 ( Spinacia oleracea )
gibberellin 2-oxidase : GA2ox1 ( Phaseolus coccineus )
gibberellin 2-oxidase : GA2ox1 ( Spinacia oleracea )
gibberellin 2-oxidase : GA2ox3 ( Oryza sativa )
gibberellin 2-oxidase : GA2ox1 ( Oryza sativa )
gibberellin 2-oxidase : GA2ox3 ( Arabidopsis thaliana col )
gibberellin 2-oxidase : GA2ox2 ( Arabidopsis thaliana col )
gibberellin 2-oxidase : GA2ox1 ( Arabidopsis thaliana col )
anthocyanidin synthase : AT4g22880 ( Arabidopsis thaliana col )
anthocyanidin synthase ( Glycine max )


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Mon Nov 24, 2014, BIOCYC13A.