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MetaCyc EC 1.14.11 -- With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into each donors

Parent Class: EC-Numbers1 -- Oxidoreductases1.14 -- Acting on paired donors, with incorporation or reduction of molecular oxygen

Instances:
1.14.11.1 -- γ-butyrobetaine dioxygenase,
1.14.11.2 -- procollagen-proline dioxygenase,
1.14.11.3 -- pyrimidine-deoxynucleoside 2′-dioxygenase,
1.14.11.4 -- procollagen-lysine 5-dioxygenase,
1.14.11.6 -- thymine dioxygenase,
1.14.11.7 -- procollagen-proline 3-dioxygenase,
1.14.11.8 -- trimethyllysine dioxygenase,
1.14.11.9 -- flavanone 3-dioxygenase,
1.14.11.10 -- pyrimidine-deoxynucleoside 1′-dioxygenase,
1.14.11.11 -- hyoscyamine (6S)-dioxygenase,
1.14.11.12 -- gibberellin-44 dioxygenase,
1.14.11.13 -- gibberellin 2β-dioxygenase,
1.14.11.14 -- 6β-hydroxyhyoscyamine epoxidase,
1.14.11.15 -- gibberellin 3β-dioxygenase,
1.14.11.16 -- peptide-aspartate β-dioxygenase,
1.14.11.17 -- taurine dioxygenase,
1.14.11.18 -- phytanoyl-CoA dioxygenase,
1.14.11.19 -- leucocyanidin oxygenase,
1.14.11.20 -- deacetoxyvindoline 4-hydroxylase,
1.14.11.21 -- clavaminate synthase,
1.14.11.22 -- flavone synthase,
1.14.11.23 -- flavonol synthase,
1.14.11.24 -- 2′-deoxymugineic-acid 2′-dioxygenase,
1.14.11.25 -- mugineic-acid 3-dioxygenase,
1.14.11.26 -- deacetoxycephalosporin-C hydroxylase,
1.14.11.27 -- [histone-H3]-lysine-36 demethylase,
1.14.11.28 -- proline 3-hydroxylase,
1.14.11.29 -- hypoxia-inducible factor-proline dioxygenase,
1.14.11.30 -- hypoxia-inducible factor-asparagine dioxygenase,
1.14.11.31 -- thebaine 6-O-demethylase,
1.14.11.32 -- codeine 3-O-demethylase,
1.14.11.33 -- DNA oxidative demethylase,
1.14.11.34 -- 2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming),
1.14.11.35 -- 1-deoxypentalenic acid 11β-hydroxylase,
1.14.11.36 -- pentalenolactone F synthase,
1.14.11.37 -- kanamycin B dioxygenase,
1.14.11.38 -- verruculogen synthase,
1.14.11.39 -- L-asparagine hydroxylase,
1.14.11.40 -- enduracididine β-hydroxylase,
1.14.11.41 -- L-arginine hydroxylase,
1.14.11.42 -- tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase ,
1.14.11.43 -- (S)-dichlorprop dioxygenase (2-oxoglutarate),
1.14.11.44 -- (R)-dichlorprop dioxygenase (2-oxoglutarate),
1.14.11.45 -- L-isoleucine 4-hydroxylase,
1.14.11.46 -- 2-aminoethylphosphonate dioxygenase,
1.14.11.47 -- 50S ribosomal protein L16 3-hydroxylase,
1.14.11.48 -- xanthine dioxygenase,
1.14.11.M1,
1.14.11.M2 -- N-3-fumaramoyl-(S)-2,3-diaminopropanoyl-[DdaD non-ribosomal peptide synthase] oxygenase,
1.14.11.v -- uridine-5'-monophosphate dioxygenase

Unofficial Reactions:
gibberellin A7 + NADPH + H+ + oxygen → gibberellin A3 + NADP+ + H2O,
3,7-dimethylquercetin + 2-oxoglutarate + oxygen → 3,7-dimethylquercetagetin + succinate + CO2,
2-chloro-4-methyl-phenoxyacetate + 2-oxoglutarate + oxygen → 2-chloro-4-methylphenol + glyoxylate + succinate + CO2,
gibberellin A12 + 2-oxoglutarate + oxygen → gibberellin A14 + succinate + CO2,
4'-methoxydehydrocyclopeptine + 2-oxoglutarate + oxygen → (-)-4'-methoxycyclopenine + succinate + CO2,
L-leucine + 2-oxoglutarate + oxygen → 4-hydroxy-L-leucine + succinate + CO2,
pentalenolactone E + 2-oxoglutarate + oxygen → pentalenolactone F + succinate + CO2,
5-hydroxy-leucine + 2-oxoglutarate + oxygen → 5,5-dihydroxy-leucine + succinate + CO2,
gibberellin A5 + 2-oxoglutarate + oxygen → gibberellin A3 + succinate + CO2,
gibberellin A44 (closed lactone form) + 2-oxoglutarate + 2 H+ + oxygen → gibberellin A98 + succinate + CO2,
gibberellin A28 + 2-oxoglutarate + oxygen → (2βOH)-gibberellin28 + succinate + CO2,
luteoforol + 2-oxoglutarate + oxygen + H+ → luteolinidin + succinate + CO2 + 2 H2O,
gibberellin A15 (open lactone form) + 2-oxoglutarate + oxygen → gibberellin A24 + succinate + CO2 + H2O,
L-threonine + 2-oxoglutarate + oxygen → 4-hydroxy-L-threonine + succinate + CO2,
apiforol + 2-oxoglutarate + oxygen → apigeninidin + succinate + CO2 + 2 H2O,
gibberellin A4 + NADPH + H+ + oxygen → gibberellin A1 + NADP+ + H2O,
gibberellin A20 + 2-oxoglutarate + oxygen → gibberellin A29 + succinate + CO2,
gibberellin A14 + 2-oxoglutarate + oxygen → gibberellin A37 + CO2 + succinate,
gibberellin A9 + 2-oxoglutarate + oxygen → gibberellin A51 + succinate + CO2,
leucodelphinidin + 2-oxoglutarate + oxygen → delphinidin + CO2 + succinate + H+ + 2 H2O,
gibberellin A5 + 2-oxoglutarate + oxygen → gibberellin A6 + succinate + CO2,
gibberellin A19 + 2-oxoglutarate + oxygen → gibberellin A20 + 2 CO2 + succinate + H+,
gibberellin A24 + 2-oxoglutarate + oxygen → gibberellin A25 + CO2 + succinate + H+,
gardenin B + 2-oxoglutarate + oxygen → nevadensin + formaldehyde + succinate + CO2,
fusicocca-2,10(14)-diene-8β,16-diol + 2-oxoglutarate + oxygen → fusicocca-1,10(14)-diene-3,8β,16-triol + succinate + CO2,
gibberellin A15 (closed lactone form) + 2-oxoglutarate + oxygen → gibberellin A37 (closed lactone form) + succinate + CO2,
2,4-dichlorophenoxyacetate + 2-oxoglutarate + oxygen → 2,4-dichlorophenol + glyoxylate + succinate + CO2,
gibberellin44 (open lactone form) + 2-oxoglutarate + H+ + oxygen → gibberellin A38 + succinate + CO2 + H2O,
3 2-oxoglutarate + L-arginine + 3 oxygen + 3 H+ → 2 ethylene + 7 CO2 + succinate + guanidinium + (S)-1-pyrroline-5-carboxylate + 3 H2O,
dehydrocyclopeptine + 2-oxoglutarate + oxygen → (-)-cyclopenine + succinate + CO2,
fusicocca-2,10(14)-diene-8β,16-diol + 2-oxoglutarate + oxygen → 8β-hydroxyfusicocca-1,10(14)-diene-16-al + succinate + CO2 + H2O,
gibberellin A25 + 2-oxoglutarate + oxygen → gibberellin A46 + succinate + CO2,
4'-methoxycyclopeptine + 2-oxoglutarate + oxygen → 4'-methoxydehydrocyclopeptine + succinate + CO2 + H2O,
L-leucine + 2-oxoglutarate + oxygen → 5-hydroxy-leucine + succinate + CO2,
gibberellin A51 + 2-oxoglutarate + oxygen → gibberellin A51-catabolite + succinate + CO2 + H+ + H2O,
a 3-methyl-branched 2,3,4-saturated fatty acyl-CoA + 2-oxoglutarate + oxygen → a 2-hydroxy-3-methyl-branched 2,3,4-saturated fatty acyl-CoA + succinate + CO2,
gibberellin A20 + an reduced unknown electron acceptor + oxygen → gibberellin A5 + an oxidized unknown electron acceptor + 2 H2O,
gibberellin A17 + 2-oxoglutarate + oxygen → gibberellin A28 + succinate + CO2,
gibberellin A12 + 2-oxoglutarate + oxygen → gibberellin A15 (open lactone form) + CO2 + succinate,
L-methionine + 2-oxoglutarate + oxygen → L-methionine S-oxide + succinate + CO2,
andilesin C + 2-oxoglutarate + oxygen → anditomin + succinate + CO2 + H2O,
3,7,4'-trimethylquercetin + 2-oxoglutarate + oxygen → 3,7,4'-trimethylquercetagetin + succinate + CO2,
gibberellin A4 + 2-oxoglutarate + oxygen → gibberellin A34 + succinate + CO2,
gibberellin A19 + 2-oxoglutarate + oxygen → gibberellin A17 + succinate + CO2 + H+,
gibberellin A9 + 2-oxoglutarate + oxygen → gibberellin A4 + succinate + CO2,
pentalenolactone D + 2-oxoglutarate + oxygen → pentalenolactone E + succinate + CO2 + H2O,
gibberellin A53 + 2-oxoglutarate + oxygen → gibberellin A97 + succinate + CO2,
gibberellin A12 + 2-oxoglutarate + oxygen → gibberellin A53 + succinate + CO2,
neopentalenolactone E + 2-oxoglutarate + oxygen → neopentalenolactone F + succinate + CO2,
L-homotyrosine + 2-oxoglutarate + oxygen → 3-hydroxy-L-homotyrosine + succinate + CO2,
gibberellin A36 + 2-oxoglutarate + NADP+ + oxygen → gibberellin A4 + succinate + 2 CO2 + NADPH,
leucopelargonidin + 2-oxoglutarate + oxygen → pelargonidin + succinate + CO2 + H+ + 2 H2O,
gibberellin A29 + 2-oxoglutarate + oxygen → gibberellin A29-catabolite + succinate + CO2 + H+ + H2O,
4-coumaryl-CoA + 2-oxoglutarate + oxygen → 2,4-dihydroxycinnamoyl-CoA + succinate + CO2,
gibberellin A24 + 2-oxoglutarate + oxygen → gibberellin A36 + succinate + CO2,
cyclopeptine + 2-oxoglutarate + oxygen → dehydrocyclopeptine + succinate + CO2 + H2O,
preandiloid C + 2-oxoglutarate + an reduced unknown electron acceptor + oxygen → andiconin + succinate + CO2 + an oxidized unknown electron acceptor + H2O,
gibberellin A13 + 2-oxoglutarate + oxygen → gibberellin A43 + succinate + CO2,
L-arginine + 2-oxoglutarate + oxygen → Nω-hydroxy-L-arginine + succinate + CO2,
FR-900098 + 2-oxoglutarate + oxygen → FR-33289 + succinate + CO2,
L-proline + 2-oxoglutarate + oxygen → cis-4-hydroxy-L-proline + succinate + CO2,
(2R,6Z)-2-hydroxy-6-(hydroxymethylidene)-2,5-dimethylcyclohex-4-ene-1,3-dione + 2-oxoglutarate + oxygen → stipitaldehyde + succinate + CO2 + H2O,
gibberellin A12-aldehyde + NADPH + H+ + oxygen → gibberellin A14-aldehyde + NADP+ + H2O,
gibberellin A34 + 2-oxoglutarate + oxygen → gibberellin A34-catabolite + succinate + CO2 + H+ + H2O,
a [protein] N6-methyl-L-lysine + 2-oxoglutarate + oxygen + H+ → a [protein]-L-lysine + succinate + formaldehyde + CO2,
L-proline + 2-oxoglutarate + oxygen → trans-4-hydroxy-L-proline + succinate + CO2,
2-hydroxyethylphosphonate + 2-oxoglutarate + oxygen → 1,2-dihydroxyethylphosphonate + succinate + CO2,
gibberellin A14-aldehyde + NADPH + oxygen → gibberellin A14 + NADP+ + H2O,
gibberellin A24 + 2-oxoglutarate + oxygen → gibberellin A9 + 2 CO2 + succinate + H+,
trans-caffeoyl-CoA + 2-oxoglutarate + oxygen → 2,4,6-trihydroxycinnamoyl-CoA + succinate + CO2,
gibberellin A53 + 2-oxoglutarate + oxygen → gibberellin44 (open lactone form) + CO2 + succinate,
neopentalenolactone D + 2-oxoglutarate + oxygen → neopentalenolactone E + succinate + CO2 + H2O,
gibberellin A37 + 2-oxoglutarate + oxygen → gibberellin A36 + succinate + CO2 + H2O,
gibberellin A9 + an reduced unknown electron acceptor + oxygen → gibberellin A40 + an oxidized unknown electron acceptor + H2O,
feruloyl-CoA + 2-oxoglutarate + oxygen → 6'-hydroxyferuloyl-CoA + succinate + CO2,
gibberellin A15 (open lactone form) + 2-oxoglutarate + oxygen → gibberellin A37 + succinate + CO2,
8-hydroxy-salvigenin + 2-oxoglutarate + oxygen → pilosin + formaldehyde + succinate + CO2,
gibberellin A8 + 2-oxoglutarate + oxygen → gibberellin A8-catabolite + succinate + CO2 + H+ + H2O,
4-chloro-2-methylphenoxyacetate + 2-oxoglutarate + oxygen → 2-methyl-4-chlorophenol + glyoxylate + succinate + CO2,
gibberellin A25 + 2-oxoglutarate + oxygen → gibberellin A13 + succinate + CO2,
gibberellin A12 + 2-oxoglutarate + oxygen → gibberellin A110 + succinate + CO2

Enzymes and Genes:
feruloyl-CoA 6'-hydroxylase: F6'H1 ( Arabidopsis thaliana col )
gibberellin 2α-hydroxylase / gibberellin 1,2-desaturase: DES ( Fusarium fujikuroi )
gibberellin 20-oxidase: GA20ox4 ( Arabidopsis thaliana col )
2-hydroxyethylphosphonate 1-hydroxylase: dhpA ( Streptomyces luridus )
proline 4-hydroxylase: D78338 ( Dactylosporangium sp. strain RH1 )
gibberellin 3β-hydroxylase / ent-kaurenoate oxidase: P450-1 ( Fusarium fujikuroi )
stipitaldehyde synthase: tropC ( Talaromyces stipitatus )
FR-33289 synthase: frbJ ( Streptomyces rubellomurinus )
L-arginine Nω-oxidase: dcsA ( Streptomyces lavendulae lavendulae )
andiconin synthase / preandiloid B dehydrogenase: andA ( Aspergillus stellatus )
4-coumaroyl 2'-hydroxylase: C2'H ( Ipomoea batatas )
4-coumaroyl 2'-hydroxylase: CYP98A22 ( Ruta graveolens )
anthocyanidin synthase: AT4g22880 ( Arabidopsis thaliana col )
anthocyanidin synthase ( Glycine max )
L-homotyrosine 3-hydroxylase: EcdG ( Aspergillus rugulosus )
neopentalenolactone D dioxygenase: ptlD ( Streptomyces avermitilis )
gibberellin C13 oxidase: CYP714B2 ( Oryza sativa Japonica Group )
gibberellin C13 oxidase: CYP714B1 ( Oryza sativa Japonica Group )
gibberellin 2-oxidase: GA2ox3 ( Spinacia oleracea )
gibberellin 2-oxidase: GA2ox8 ( Arabidopsis thaliana col )
gibberellin 2-oxidase: GA2ox7 ( Arabidopsis thaliana col )
gibberellin 3-oxidase: GA3ox2 ( Arabidopsis thaliana col )
gibberellin 3-oxidase: GA3ox3 ( Cucurbita maxima )
gibberellin 3-oxidase: GA3ox1 ( Spinacia oleracea )
gibberellin 3-oxidase: GA3ox1 ( Phaseolus coccineus )
anditomin synthase: andF ( Aspergillus stellatus )
phytanoyl-CoA dioxygenase, peroxisomal: Phyh ( Rattus norvegicus )
phytanoyl-CoA dioxygenase, peroxisomal: PHYH ( Homo sapiens )
fusicocca-2,10(14)-diene-8β,16-diol dioxygenase: fc-dox ( Diaporthe amygdali )
2,4-dichlorophenoxyacetate dioxygenase: tfdA ( Ralstonia eutropha JMP134 )
gibberellin 3-oxidase: GA3ox1 ( Arabidopsis thaliana col )
fusicocca-2,10(14)-diene-8β,16-diol dioxygenase: bc-dox ( Alternaria brassicicola ATCC 96836 )
gardenin B 7-O-demethylase / 8-hydroxy-salvigenin 7-O-demethylase ( Ocimum basilicum )
gibberellin 20-oxidase: SD1 ( Oryza sativa )
anthocyanidin synthase: ans ( Vaccinium myrtillus )
gibberellin 2-oxidase: GA2ox1 ( Pisum sativum )
gibberellin 2-oxidase: GA2ox2 ( Spinacia oleracea )
gibberellin 2-oxidase: GA2ox1 ( Phaseolus coccineus )
gibberellin 2-oxidase: GA2ox1 ( Spinacia oleracea )
gibberellin 2-oxidase: GA2ox3 ( Oryza sativa )
gibberellin 2-oxidase: GA2ox3 ( Arabidopsis thaliana col )
gibberellin 2-oxidase: GA2ox2 ( Arabidopsis thaliana col )
gibberellin 2-oxidase: GA2ox1 ( Arabidopsis thaliana col )
gibberellin 20-oxidase: GA20ox2 ( Cucurbita maxima )
gibberellin 20-oxidase: GA20ox1D ( Triticum aestivum )
gibberellin 20-oxidase: GA20ox ( Cucurbita maxima )
gibberellin 20-oxidase: GA20ox3 ( Arabidopsis thaliana col )
gibberellin 20-oxidase: GA20ox2 ( Arabidopsis thaliana col )
gibberellin 20-oxidase: GA20ox1 ( Arabidopsis thaliana col )
gibberellin 20-oxidase: GA20ox ( Pisum sativum )
gibberellin 2-oxidase: GA2ox1 ( Oryza sativa )
gibberellin 3-oxidase (multifunctional): GA3ox2-1 ( Triticum aestivum )
gibberellin 2β,3β-hydroxylase: GA3ox1 ( Oryza sativa )
leucine 5-hydroxylase: EcdK ( Aspergillus rugulosus )
pentalenolactone D dioxygenase: penD ( Streptomyces exfoliatus )
L-threonine 4-hydroxylase: tdo ( Bordetella petrii DSM 12804 )
L-isoleucine-4-hydroxylase: ido ( Bacillus thuringiensis )
4'-methoxycyclopenine synthase: AsqJ ( Aspergillus nidulans )
gibberellin 2β,3β-hydroxylase: GA3ox1 ( Cucurbita maxima )
flavonol 6-hydroxylase: F6H ( Chrysosplenium americanum )
gibberellin 13-hydroxylase: P450-3 ( Fusarium fujikuroi )


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Tue Feb 9, 2016, BIOCYC11A.