MetaCyc Compound Class: carboxymethyl cellulose

Synonyms: cellulose gum, CMC, E466, carboxymethylcellulose

Superclasses: all carbohydratesa carbohydratea glycana polysaccharide

Carboxymethylcellulose (CMC) is a cellulose derivative with carboxymethyl groups bound to some of the hydroxyl groups of the glucopyranose monomers that make up the cellulose backbone. It is often used as its sodium salt, sodium carboxymethyl cellulose. Unlike unmodified cellulose, carboxymethylcellulose is soluble in water.

CMC is used in food science as a viscosity modifier or thickener, and to stabilize emulsions in various products including ice cream. It is also a constituent of many non-food products, such as K-Y Jelly, toothpaste, laxatives, diet pills, water-based paints, detergents, textile sizing and various paper products.

carboxymethyl cellulose compound structure

SMILES: C([O-])(=O)COCC4(OC(OC1(C(OCC(=O)[O-])C(O)C(OC(CO)1)OC2(C(O)C(OCC(=O)[O-])C(OC(CO)2)OC3(C(O)C(O)C([R2])OC(COCC([O-])=O)3))))C(O)C(O)C([R1])4)

Unification Links: Wikipedia:Carboxymethyl_cellulose

Reactions known to produce the compound:

cellulose and hemicellulose degradation (cellulolosome) :
a feruloyl-polysaccharide + H2O → ferulate + a polysaccharide + H+

Enzymes activated by carboxymethyl cellulose, sorted by the type of activation, are:

Activator (Mechanism unknown) of: cellulase [Nakazawa08]

This compound has been characterized as an alternative substrate of the following enzymes: endo-1,4-β-xylanase, cellulase, cellulase, cellulose 1,4-β-cellobiosidase, cellulase, cellulase, cellulase, cellulase, cellulase

Created 28-Mar-2011 by Caspi R, SRI International


Nakazawa08: Nakazawa H, Okada K, Kobayashi R, Kubota T, Onodera T, Ochiai N, Omata N, Ogasawara W, Okada H, Morikawa Y (2008). "Characterization of the catalytic domains of Trichoderma reesei endoglucanase I, II, and III, expressed in Escherichia coli." Appl Microbiol Biotechnol 81(4);681-9. PMID: 18762935

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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