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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
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for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Escherichia coli K-12 substr. MG1655 Reaction: 3.6.1.45

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.6.1.45

Enzymes and Genes:
UDP-sugar hydrolase Inferred from experiment : ushA

Reaction Locations: periplasmic space (sensu Gram-negative Bacteria)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Marked as unbalanced.

Enzyme Commission Primary Name: UDP-sugar diphosphatase

Enzyme Commission Synonyms: nucleosidediphosphate-sugar pyrophosphatase, nucleosidediphosphate-sugar diphosphatase, UDP-sugar hydrolase, UDP-sugar pyrophosphatase

Enzyme Commission Summary:
A divalent cation is required for activity. UDP-sugar is the best substrate, although other nucleoside-sugar diphosphates are used as substrates with similar Km values but much lower maximum velocities. Thus, this enzyme has a specificity distinct from that of ADP-sugar diphosphatase (EC 3.6.1.21). Some but not all enzymes of this class also appear to have 5′-nucleotidase (see EC 3.1.3.5) activity.

Citations: [Glaser67, Garrett89]

Gene-Reaction Schematic: ?

Instance reactions of [a ribonucleoside 5'-monophosphate + H2O → a ribonucleoside + phosphate] (3.1.3.5):
i1: CMP + H2O → cytidine + phosphate (3.1.3.91)

i2: UMP + H2O → uridine + phosphate (3.1.3.5)

i3: AMP + H2O → adenosine + phosphate (3.1.3.5)

Instance reactions of [a 2'-deoxyribonucleoside 5'-monophosphate + H2O → a 2'-deoxynucleoside + phosphate] (3.1.3.89):
i4: dTMP + H2O → thymidine + phosphate (3.1.3.89)

i5: dAMP + H2O → 2'-deoxyadenosine + phosphate (3.1.3.89)

i6: dCMP + H2O → 2'-deoxycytidine + phosphate (3.1.3.89)

i7: dGMP + H2O → 2'-deoxyguanosine + phosphate (3.1.3.89)

i8: dUMP + H2O → 2'-deoxyuridine + phosphate (3.1.3.89)

Relationship Links: BRENDA:EC:3.6.1.45 , ENZYME:EC:3.6.1.45 , IUBMB-ExplorEnz:EC:3.6.1.45


References

Garrett89: Garrett AR, Johnson LA, Beacham IR (1989). "Isolation, molecular characterization and expression of the ushB gene of Salmonella typhimurium which encodes a membrane-bound UDP-sugar hydrolase." Mol Microbiol 3(2);177-86. PMID: 2548058

Glaser67: Glaser L, Melo A, Paul R (1967). "Uridine diphosphate sugar hydrolase. Purification of enzyme and protein inhibitor." J Biol Chem 1967;242(8);1944-54. PMID: 5337593


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Sun Dec 21, 2014, BIOCYC14A.