Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
twitter

Escherichia coli K-12 substr. MG1655 Reaction: 3.6.1.45

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.6.1.45

Enzymes and Genes:
UDP-sugar hydrolase Inferred from experiment : ushA

Reaction Locations: periplasmic space (sensu Gram-negative Bacteria)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Marked as unbalanced.

Enzyme Commission Primary Name: UDP-sugar diphosphatase

Enzyme Commission Synonyms: nucleosidediphosphate-sugar pyrophosphatase, nucleosidediphosphate-sugar diphosphatase, UDP-sugar hydrolase, UDP-sugar pyrophosphatase

Enzyme Commission Summary:
A divalent cation is required for activity. UDP-sugar is the best substrate, although other nucleoside-sugar diphosphates are used as substrates with similar Km values but much lower maximum velocities. Thus, this enzyme has a specificity distinct from that of ADP-sugar diphosphatase (EC 3.6.1.21). Some but not all enzymes of this class also appear to have 5′-nucleotidase (see EC 3.1.3.5) activity.

Citations: [Glaser67, Garrett89]

Gene-Reaction Schematic: ?

Instance reactions of [a ribonucleoside 5'-monophosphate + H2O → a ribonucleoside + phosphate] (3.1.3.5):
i1: CMP + H2O → cytidine + phosphate (3.1.3.91)

i2: UMP + H2O → uridine + phosphate (3.1.3.5)

i3: AMP + H2O → adenosine + phosphate (3.1.3.5)

Instance reactions of [a 2'-deoxyribonucleoside 5'-monophosphate + H2O → a 2'-deoxynucleoside + phosphate] (3.1.3.89):
i4: dTMP + H2O → thymidine + phosphate (3.1.3.89)

i5: dAMP + H2O → 2'-deoxyadenosine + phosphate (3.1.3.89)

i6: dCMP + H2O → 2'-deoxycytidine + phosphate (3.1.3.89)

i7: dGMP + H2O → 2'-deoxyguanosine + phosphate (3.1.3.89)

i8: dUMP + H2O → 2'-deoxyuridine + phosphate (3.1.3.89)

Relationship Links: BRENDA:EC:3.6.1.45 , ENZYME:EC:3.6.1.45 , IUBMB-ExplorEnz:EC:3.6.1.45


References

Garrett89: Garrett AR, Johnson LA, Beacham IR (1989). "Isolation, molecular characterization and expression of the ushB gene of Salmonella typhimurium which encodes a membrane-bound UDP-sugar hydrolase." Mol Microbiol 3(2);177-86. PMID: 2548058

Glaser67: Glaser L, Melo A, Paul R (1967). "Uridine diphosphate sugar hydrolase. Purification of enzyme and protein inhibitor." J Biol Chem 1967;242(8);1944-54. PMID: 5337593


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Mon Nov 24, 2014, BIOCYC14A.