|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 188.8.131.52
Reaction Locations: periplasmic space (sensu Gram-negative Bacteria)
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Marked as unbalanced.
Enzyme Commission Primary Name: UDP-sugar diphosphatase
Enzyme Commission Synonyms: nucleosidediphosphate-sugar pyrophosphatase, nucleosidediphosphate-sugar diphosphatase, UDP-sugar hydrolase, UDP-sugar pyrophosphatase
Enzyme Commission Summary:
A divalent cation is required for activity. UDP-sugar is the best substrate, although other nucleoside-sugar diphosphates are used as substrates with similar Km values but much lower maximum velocities. Thus, this enzyme has a specificity distinct from that of ADP-sugar diphosphatase (EC 184.108.40.206). Some but not all enzymes of this class also appear to have 5′-nucleotidase (see EC 220.127.116.11) activity.
Instance reaction of [a nucleoside 5'-monophosphate[periplasmic space] + H2O[periplasmic space] → a nucleoside[periplasmic space] + phosphate[periplasmic space]] (no EC#):
i1: a ribonucleoside 5'-monophosphate + H2O → a ribonucleoside + phosphate (18.104.22.168)
Instance reactions of [a ribonucleoside 5'-monophosphate + H2O → a ribonucleoside + phosphate] (22.214.171.124):
i2: AMP + H2O → adenosine + phosphate (126.96.36.199)
i3: CMP + H2O → cytidine + phosphate (188.8.131.52/184.108.40.206)
i4: UMP + H2O → uridine + phosphate (220.127.116.11)
Instance reactions of [a 2'-deoxyribonucleoside 5'-monophosphate + H2O → a 2'-deoxynucleoside + phosphate] (18.104.22.168):
i5: dUMP + H2O → 2'-deoxyuridine + phosphate (22.214.171.124)
i6: dCMP + H2O → 2'-deoxycytidine + phosphate (126.96.36.199)
i7: dTMP + H2O → thymidine + phosphate (188.8.131.52/184.108.40.206)
i8: dGMP + H2O → 2'-deoxyguanosine + phosphate (220.127.116.11)
i9: dAMP + H2O → 2'-deoxyadenosine + phosphate (18.104.22.168)
Garrett89: Garrett AR, Johnson LA, Beacham IR (1989). "Isolation, molecular characterization and expression of the ushB gene of Salmonella typhimurium which encodes a membrane-bound UDP-sugar hydrolase." Mol Microbiol 3(2);177-86. PMID: 2548058
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