|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
Reaction Locations: periplasm (sensu Gram-negative Bacteria)
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Marked as unbalanced.
Enzyme Commission Primary Name: UDP-sugar diphosphatase
Enzyme Commission Synonyms: nucleosidediphosphate-sugar pyrophosphatase, nucleosidediphosphate-sugar diphosphatase, UDP-sugar hydrolase, UDP-sugar pyrophosphatase
Enzyme Commission Summary:
A divalent cation is required for activity. UDP-sugar is the best substrate, although other nucleoside-sugar diphosphates are used as substrates with similar Km values but much lower maximum velocities. Thus, this enzyme has a specificity distinct from that of ADP-sugar diphosphatase ( EC 22.214.171.124). Some but not all enzymes of this class also appear to have 5′-nucleotidase (see EC 126.96.36.199) activity.
Instance reactions of [a ribonucleoside 5'-monophosphate + H2O → a ribonucleoside + phosphate] (188.8.131.52):
i1: UMP + H2O → uridine + phosphate (184.108.40.206)
i2: CMP + H2O → cytidine + phosphate (220.127.116.11/18.104.22.168)
i3: AMP + H2O → adenosine + phosphate (22.214.171.124)
Instance reactions of [a 2'-deoxyribonucleoside 5'-monophosphate + H2O → a 2'-deoxynucleoside + phosphate] (126.96.36.199):
i4: dGMP + H2O → 2'-deoxyguanosine + phosphate (188.8.131.52)
i5: dAMP + H2O → 2'-deoxyadenosine + phosphate (184.108.40.206)
i6: dUMP + H2O → 2'-deoxyuridine + phosphate (220.127.116.11)
i7: dCMP + H2O → 2'-deoxycytidine + phosphate (18.104.22.168)
i8: dTMP + H2O → thymidine + phosphate (22.214.171.124/126.96.36.199)
Garrett89: Garrett AR, Johnson LA, Beacham IR (1989). "Isolation, molecular characterization and expression of the ushB gene of Salmonella typhimurium which encodes a membrane-bound UDP-sugar hydrolase." Mol Microbiol 3(2);177-86. PMID: 2548058
©2015 SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025-3493