Escherichia coli K-12 substr. MG1655 Reaction: transport of 4-amino-2-methyl-5-pyrimidinemethanol

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsTransport ReactionsTransport Reactions of Unknown Mechanism
Reactions Classified By SubstrateSmall-Molecule Reactions

Transport reaction diagram

Reaction Locations: inner membrane (sensu Gram-negative Bacteria)

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Phosphorylation of hydroxymethylpyrimidine (HMP) by HMP kinase is the first step in a non-essential salvage reaction of the superpathway of thiamine diphosphate biosynthesis I pathway. This pathway is common to both E.coli and S. typhimurium and has been extensively studied in both organisms. Salvage of HMP from the culture medium has been experimentally demonstrated in S. typhimurium [Bellion83].

Created 13-Apr-2011 by Mackie A, Macquarie University


Bellion83: Bellion E, Lash TD (1983). "Transport of 2-methyl-4-amino-5-hydroxymethylpyrimidine by Salmonella typhimurium." Biochim Biophys Acta 735(3);337-40. PMID: 6357279

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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