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Escherichia coli K-12 substr. MG1655 Reaction: 2.7.1.145


Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 2.7.1.145

Enzymes and Genes:
thymidine kinaseInferred from experiment: tdk

In Pathway: salvage pathways of pyrimidine deoxyribonucleotides

Note that this reaction equation differs from the official Enzyme Commission reaction equations for this EC number.

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: deoxynucleoside kinase

Enzyme Commission Synonyms: multispecific deoxynucleoside kinase, ms-dNK, multisubstrate deoxyribonucleoside kinase, multifunctional deoxynucleoside kinase, D. melanogaster deoxynucleoside kinase, Dm-dNK

Summary:
This reaction is part of the pyrimidine salvage pathway.

Enzyme Commission Summary:
The enzyme from embryonic cells of Drosophila melanogaster differs from other deoxynucleoside kinases (EC 2.7.1.76 and EC 2.7.1.113) in its broad specificity for all four common deoxynucleosides.

Citations: [MunchPetersen00, MunchPetersen98]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:2.7.1.145, ENZYME:EC:2.7.1.145, IUBMB-ExplorEnz:EC:2.7.1.145


References

MunchPetersen00: Munch-Petersen B, Knecht W, Lenz C, Sondergaard L, Piskur J (2000). "Functional expression of a multisubstrate deoxyribonucleoside kinase from Drosophila melanogaster and its C-terminal deletion mutants." J Biol Chem 275(9);6673-9. PMID: 10692477

MunchPetersen98: Munch-Petersen B, Piskur J, Sondergaard L (1998). "Four deoxynucleoside kinase activities from Drosophila melanogaster are contained within a single monomeric enzyme, a new multifunctional deoxynucleoside kinase." J Biol Chem 273(7);3926-31. PMID: 9461577


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by Pathway Tools version 19.5 (software by SRI International) on Wed May 4, 2016, biocyc13.