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Escherichia coli K-12 substr. MG1655 Reaction: 2.7.1.145

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.7.1.145

Enzymes and Genes:
thymidine kinase Inferred from experiment : tdk

In Pathway: salvage pathways of pyrimidine deoxyribonucleotides

Note that this reaction equation differs from the official Enzyme Commission reaction equations for this EC number.

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: deoxynucleoside kinase

Enzyme Commission Synonyms: multispecific deoxynucleoside kinase, ms-dNK, multisubstrate deoxyribonucleoside kinase, multifunctional deoxynucleoside kinase, D. melanogaster deoxynucleoside kinase, Dm-dNK

Summary:
This reaction is part of the pyrimidine salvage pathway.

Enzyme Commission Summary:
The enzyme from embryonic cells of Drosophila melanogaster differs from other deoxynucleoside kinases (EC 2.7.1.76 and EC 2.7.1.113) in its broad specificity for all four common deoxynucleosides.

Citations: [MunchPetersen00, MunchPetersen98]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:2.7.1.145 , ENZYME:EC:2.7.1.145 , IUBMB-ExplorEnz:EC:2.7.1.145


References

MunchPetersen00: Munch-Petersen B, Knecht W, Lenz C, Sondergaard L, Piskur J (2000). "Functional expression of a multisubstrate deoxyribonucleoside kinase from Drosophila melanogaster and its C-terminal deletion mutants." J Biol Chem 275(9);6673-9. PMID: 10692477

MunchPetersen98: Munch-Petersen B, Piskur J, Sondergaard L (1998). "Four deoxynucleoside kinase activities from Drosophila melanogaster are contained within a single monomeric enzyme, a new multifunctional deoxynucleoside kinase." J Biol Chem 273(7);3926-31. PMID: 9461577


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Sat Feb 28, 2015, BIOCYC14A.