|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 184.108.40.206
Note that this reaction equation differs from the official Enzyme Commission reaction equations for this EC number.
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: deoxynucleoside kinase
Enzyme Commission Synonyms: multispecific deoxynucleoside kinase, ms-dNK, multisubstrate deoxyribonucleoside kinase, multifunctional deoxynucleoside kinase, D. melanogaster deoxynucleoside kinase, Dm-dNK
This reaction is part of the pyrimidine salvage pathway.
Enzyme Commission Summary:
The enzyme from embryonic cells of Drosophila melanogaster differs from other deoxynucleoside kinases (EC 220.127.116.11 and EC 18.104.22.168) in its broad specificity for all four common deoxynucleosides.
MunchPetersen00: Munch-Petersen B, Knecht W, Lenz C, Sondergaard L, Piskur J (2000). "Functional expression of a multisubstrate deoxyribonucleoside kinase from Drosophila melanogaster and its C-terminal deletion mutants." J Biol Chem 275(9);6673-9. PMID: 10692477
MunchPetersen98: Munch-Petersen B, Piskur J, Sondergaard L (1998). "Four deoxynucleoside kinase activities from Drosophila melanogaster are contained within a single monomeric enzyme, a new multifunctional deoxynucleoside kinase." J Biol Chem 273(7);3926-31. PMID: 9461577
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