Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:
alkaline phosphataseInferred from experiment: phoA
phosphosugar phosphataseInferred from experiment: yigL
sugar phosphataseInferred from experiment: yidA
sugar phosphataseInferred from experiment: yfbT
sugar phosphataseInferred from experiment: ybiV

Reaction Locations: periplasm (sensu Gram-negative Bacteria), cytosol

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balance undetermined; a substrate lacks a chemical formula

Instance reactions:
L-glyceraldehyde 3-phosphate + H2O → L-glyceraldehyde + phosphate (3.1.3.-)

glycerone phosphate + H2O → dihydroxyacetone + phosphate (3.1.3.-)

D-glyceraldehyde 3-phosphate + H2O → D-glyceraldehyde + phosphate (3.1.3.-)

a hexose phosphate + H2O → a hexose + phosphate (3.1.3.-)

α-D-glucopyranose 1-phosphate + H2O → D-glucopyranose + phosphate (

α-D-glucose 6-phosphate + H2O → α-D-glucopyranose + phosphate (

β-D-glucose 6-phosphate + H2O → β-D-glucopyranose + phosphate (

β-D-fructofuranose 1-phosphate + H2O → β-D-fructofuranose + phosphate (3.1.3.-)

Enzyme Commission Primary Name: sugar-phosphatase

Enzyme Commission Summary:
Has a wide specificity, acting on aldohexose 1-phosphates, ketohexose 1-phosphates, aldohexose 6-phosphates, ketohexose 6-phosphates, both phosphate ester bonds of fructose 1,6-bisphosphate, phosphoric esters of disaccharides, and on pentose and triose phosphates, but at a slower rate.

Citations: [Lee67]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Lee67: Lee YP, Sowokinos JR (1967). "Sugar phosphate phosphohydrolase. I. Substrate specificity, intracellular localization, and purification from Neisseria meningitidis." J Biol Chem 242(9);2264-71. PMID: 4290224

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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