Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Protein-Modification Reactions
Reactions Classified By Substrate Macromolecule Reactions Protein-Reactions Protein-Modification Reactions

EC Number:

Enzymes and Genes:
ribonucleoside-triphosphate reductase Inferred from experiment : nrdD

In Pathway: superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) , pyrimidine deoxyribonucleotides de novo biosynthesis II

Note that this reaction equation differs from the official Enzyme Commission reaction equations for this EC number.

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: ribonucleoside-triphosphate reductase

Enzyme Commission Synonyms: ribonucleotide reductase, 2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase

Enzyme Commission Summary:
Requires a cobamide coenzyme and ATP.

Citations: [Blakley65, Goulian66]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:


Blakley65: Blakley RL (1965). "Cobamides and ribonucleotide reduction. I. Cobamide stimulation of ribonucleotide reduction in extracts of Lactobacillus leichmannii." J Biol Chem 240;2173-80. PMID: 14299643

Goulian66: Goulian M, Beck WS (1966). "Purification and properties of cobamide-dependent ribonucleotide reductase from Lactobacillus leichmannii." J Biol Chem 241(18);4233-42. PMID: 5924645

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Thu Jul 30, 2015, biocyc13.