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Escherichia coli K-12 substr. MG1655 Reaction: 2.7.7.56


Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateMacromolecule ReactionsPolynucleotide-ReactionsRNA-ReactionstRNA-Reactions

EC Number: 2.7.7.56

Enzymes and Genes:
RNase PHInferred from experiment: rph

In Pathway: tRNA processing

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Marked as unbalanced.

Enzyme Commission Primary Name: tRNA nucleotidyltransferase

Enzyme Commission Synonyms: phosphate-dependent exonuclease, RNase PH, ribonuclease PH

Enzyme Commission Summary:
Brings about the final exonucleolytic trimming of the 3-terminus of tRNA precursors in Escherichia coli by a phosphorolysis, producing a mature 3-terminus on tRNA and nucleoside diphosphate. Not identical with EC 2.7.7.8 polyribonucleotide nucleotidyltransferase.

Citations: [Cudny88, Deutscher88]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:2.7.7.56, ENZYME:EC:2.7.7.56, IUBMB-ExplorEnz:EC:2.7.7.56

Credits:
Created 16-Jun-2010 by Shearer A, SRI International


References

Cudny88: Cudny H, Deutscher MP (1988). "3' processing of tRNA precursors in ribonuclease-deficient Escherichia coli. Development and characterization of an in vitro processing system and evidence for a phosphate requirement." J Biol Chem 263(3);1518-23. PMID: 3275667

Deutscher88: Deutscher MP, Marshall GT, Cudny H (1988). "RNase PH: an Escherichia coli phosphate-dependent nuclease distinct from polynucleotide phosphorylase." Proc Natl Acad Sci U S A 85(13);4710-4. PMID: 2455297


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by Pathway Tools version 19.5 (software by SRI International) on Thu Feb 11, 2016, biocyc14.