Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Macromolecule Reactions Polynucleotide-Reactions RNA-Reactions tRNA-Reactions

EC Number:

Enzymes and Genes:
tRNAMet cytidine acetyltransferase Inferred from experiment : tmcA

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: tRNAMet cytidine acetyltransferase

Enzyme Commission Synonyms: YpfI, TmcA

Enzyme Commission Summary:
The enzyme acetylates the wobble base C34 of the CAU anticodon of elongation-specific tRNAMet. Escherichia coli TmcA strictly discriminates elongator tRNAMet from tRNAIle, that is structurally similar and has the same anticodon loop, by mainly recognizing the C27-G43 pair in the anticodon stem. The enzyme can use GTP in place of ATP for formation of N4-acetylcytidine [Ikeuchi08].

Citations: [Chimnaronk09]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:


Chimnaronk09: Chimnaronk S, Suzuki T, Manita T, Ikeuchi Y, Yao M, Suzuki T, Tanaka I (2009). "RNA helicase module in an acetyltransferase that modifies a specific tRNA anticodon." EMBO J 28(9):1362-73. PMID: 19322199

Ikeuchi08: Ikeuchi Y, Kitahara K, Suzuki T (2008). "The RNA acetyltransferase driven by ATP hydrolysis synthesizes N(4)-acetylcytidine of tRNA anticodon." EMBO J 27(16):2194-203. PMID: 18668122

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Wed Oct 7, 2015, biocyc14.