Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateMacromolecule ReactionsPolynucleotide-ReactionsRNA-ReactionstRNA-Reactions

EC Number:

Enzymes and Genes:
tRNAMet cytidine acetyltransferaseInferred from experiment: tmcA

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: tRNAMet cytidine acetyltransferase

Enzyme Commission Synonyms: YpfI, TmcA

Enzyme Commission Summary:
The enzyme acetylates the wobble base C34 of the CAU anticodon of elongation-specific tRNAMet. Escherichia coli TmcA strictly discriminates elongator tRNAMet from tRNAIle, that is structurally similar and has the same anticodon loop, by mainly recognizing the C27-G43 pair in the anticodon stem. The enzyme can use GTP in place of ATP for formation of N4-acetylcytidine [Ikeuchi08].

Citations: [Chimnaronk09]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Chimnaronk09: Chimnaronk S, Suzuki T, Manita T, Ikeuchi Y, Yao M, Suzuki T, Tanaka I (2009). "RNA helicase module in an acetyltransferase that modifies a specific tRNA anticodon." EMBO J 28(9):1362-73. PMID: 19322199

Ikeuchi08: Ikeuchi Y, Kitahara K, Suzuki T (2008). "The RNA acetyltransferase driven by ATP hydrolysis synthesizes N(4)-acetylcytidine of tRNA anticodon." EMBO J 27(16):2194-203. PMID: 18668122

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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