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Escherichia coli K-12 substr. MG1655 Reaction: 2.4.1.44


Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 2.4.1.44

Enzymes and Genes:
UDP-D-galactose:(glucosyl)lipopolysaccharide-1,6-D-galactosyltransferaseInferred from experiment: waaB

In Pathway: Lipid A-core biosynthesis

Note that this reaction equation differs from the official Enzyme Commission reaction equations for this EC number.

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: lipopolysaccharide 3-α-galactosyltransferase

Enzyme Commission Synonyms: UDP-galactose:lipopolysaccharide α,3-galactosyltransferase, UDP-galactose:polysaccharide galactosyltransferase, uridine diphosphate galactose:lipopolysaccharide α-3-galactosyltransferase, uridine diphosphogalactose-lipopolysaccharide α,3-galactosyltransferase, UDP-galactose:lipopolysaccharide 3-α-D-galactosyltransferase

Enzyme Commission Summary:
Transfers α-D-galactosyl residues to D-glucose in the partially completed core of lipopolysaccharide [cf. EC 2.4.1.56 (lipopolysaccharide N-acetylglucosaminyltransferase), EC 2.4.1.58 (lipopolysaccharide glucosyltransferase I) and EC 2.4.1.73 (lipopolysaccharide glucosyltransferase II)].

Citations: [Endo69, Wollin83]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:2.4.1.44, ENZYME:EC:2.4.1.44, IUBMB-ExplorEnz:EC:2.4.1.44


References

Endo69: Endo A, Rothfield L (1969). "Studies of a phospholipid-requiring bacterial enzyme. I. Purification and properties of uridine diphosphate galactose: lipopolysaccharide alpha-3-galactosyl transferase." Biochemistry 8(9);3500-7. PMID: 4898284

Wollin83: Wollin R, Creeger ES, Rothfield LI, Stocker BA, Lindberg AA (1983). "Salmonella typhimurium mutants defective in UDP-D-galactose:lipopolysaccharide alpha 1,6-D-galactosyltransferase. Structural, immunochemical, and enzymologic studies of rfaB mutants." J Biol Chem 258(6);3769-74. PMID: 6403519


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by Pathway Tools version 19.5 (software by SRI International) on Fri Apr 29, 2016, biocyc14.