Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:
N-acetylmuramic acid 6-phosphate etheraseInferred from experiment: murQ

In Pathway: anhydromuropeptides recycling

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: N-acetylmuramic acid 6-phosphate etherase

Enzyme Commission Synonyms: MurNAc-6-P etherase, MurQ

Enzyme Commission Summary:
This enzyme, along with EC, anhydro-N-acetylmuramic acid kinase, is required for the utilization of anhydro-N-acetylmuramic acid in proteobacteria. The substrate is either imported from the medium or derived from the bacterium's own cell wall murein during cell wall recycling.

Citations: [Jaeger05, Uehara05, Uehara06, Hadi08, Jaeger08]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Hadi08: Hadi T, Dahl U, Mayer C, Tanner ME (2008). "Mechanistic studies on N-acetylmuramic acid 6-phosphate hydrolase (MurQ): an etherase involved in peptidoglycan recycling." Biochemistry 47(44);11547-58. PMID: 18837509

Jaeger05: Jaeger T, Arsic M, Mayer C (2005). "Scission of the lactyl ether bond of N-acetylmuramic acid by Escherichia coli "etherase"." J Biol Chem 280(34);30100-6. PMID: 15983044

Jaeger08: Jaeger T, Mayer C (2008). "N-acetylmuramic acid 6-phosphate lyases (MurNAc etherases): role in cell wall metabolism, distribution, structure, and mechanism." Cell Mol Life Sci 65(6);928-39. PMID: 18049859

Uehara05: Uehara T, Suefuji K, Valbuena N, Meehan B, Donegan M, Park JT (2005). "Recycling of the anhydro-N-acetylmuramic acid derived from cell wall murein involves a two-step conversion to N-acetylglucosamine-phosphate." J Bacteriol 187(11);3643-9. PMID: 15901686

Uehara06: Uehara T, Suefuji K, Jaeger T, Mayer C, Park JT (2006). "MurQ Etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall." J Bacteriol 188(4);1660-2. PMID: 16452451

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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