|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 22.214.171.124
In Pathway: anhydromuropeptides recycling
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
Enzyme Commission Primary Name: N-acetylmuramic acid 6-phosphate etherase
Enzyme Commission Synonyms: MurNAc-6-P etherase, MurQ
Enzyme Commission Summary:
This enzyme, along with EC 126.96.36.199, anhydro-N-acetylmuramic acid kinase, is required for the utilization of anhydro-N-acetylmuramic acid in proteobacteria. The substrate is either imported from the medium or derived from the bacterium's own cell wall murein during cell wall recycling.
Hadi08: Hadi T, Dahl U, Mayer C, Tanner ME (2008). "Mechanistic studies on N-acetylmuramic acid 6-phosphate hydrolase (MurQ): an etherase involved in peptidoglycan recycling." Biochemistry 47(44);11547-58. PMID: 18837509
Jaeger08: Jaeger T, Mayer C (2008). "N-acetylmuramic acid 6-phosphate lyases (MurNAc etherases): role in cell wall metabolism, distribution, structure, and mechanism." Cell Mol Life Sci 65(6);928-39. PMID: 18049859
Uehara05: Uehara T, Suefuji K, Valbuena N, Meehan B, Donegan M, Park JT (2005). "Recycling of the anhydro-N-acetylmuramic acid derived from cell wall murein involves a two-step conversion to N-acetylglucosamine-phosphate." J Bacteriol 187(11);3643-9. PMID: 15901686
Uehara06: Uehara T, Suefuji K, Jaeger T, Mayer C, Park JT (2006). "MurQ Etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall." J Bacteriol 188(4);1660-2. PMID: 16452451
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