Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:
D-sedoheptulose 7-phosphate isomeraseInferred from experiment: lpcA

In Pathway: ADP-L-glycero-β-D-manno-heptose biosynthesis

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: D-sedoheptulose 7-phosphate isomerase

Enzyme Commission Synonyms: sedoheptulose-7-phosphate isomerase, phosphoheptose isomerase, gmhA (gene name), lpcA (gene name)

Enzyme Commission Summary:
In Gram-negative bacteria the enzyme is involved in biosynthesis of ADP-L-glycero-β-D-manno-heptose, which is utilized for assembly of the lipopolysaccharide inner core. In Gram-positive bacteria the enzyme is involved in biosynthesis of GDP-D-glycero-α-D-manno-heptose, which is required for assembly of S-layer glycoprotein.

Citations: [Kneidinger02, Kneidinger01, Valvano02, Kim09e, Taylor08]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Kim09e: Kim MS, Shin DH (2009). "A preliminary X-ray study of sedoheptulose-7-phosphate isomerase from Burkholderia pseudomallei." Acta Crystallogr Sect F Struct Biol Cryst Commun 65(Pt 11);1110-2. PMID: 19923728

Kneidinger01: Kneidinger B, Graninger M, Puchberger M, Kosma P, Messner P (2001). "Biosynthesis of nucleotide-activated D-glycero-D-manno-heptose." J Biol Chem 276(24);20935-44. PMID: 11279237

Kneidinger02: Kneidinger B, Marolda C, Graninger M, Zamyatina A, McArthur F, Kosma P, Valvano MA, Messner P (2002). "Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli." J Bacteriol 184(2);363-9. PMID: 11751812

Taylor08: Taylor PL, Blakely KM, de Leon GP, Walker JR, McArthur F, Evdokimova E, Zhang K, Valvano MA, Wright GD, Junop MS (2008). "Structure and function of GmhA (sedoheptulose 7-phosphate isomerase): A critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants." J Biol Chem 283(5):2835-45. PMID: 18056714

Valvano02: Valvano MA, Messner P, Kosma P (2002). "Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides." Microbiology 148(Pt 7);1979-89. PMID: 12101286

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.5 on Sat Nov 28, 2015, BIOCYC13A.