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Metabolic Modeling Tutorial
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discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
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Escherichia coli K-12 substr. MG1655 Reaction: 5.3.1.28

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 5.3.1.28

Enzymes and Genes:
D-sedoheptulose 7-phosphate isomerase Inferred from experiment : lpcA

In Pathway: ADP-L-glycero-β-D-manno-heptose biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: D-sedoheptulose 7-phosphate isomerase

Enzyme Commission Synonyms: sedoheptulose-7-phosphate isomerase, phosphoheptose isomerase, gmhA (gene name), lpcA (gene name)

Enzyme Commission Summary:
In Gram-negative bacteria the enzyme is involved in biosynthesis of ADP-L-glycero-β-D-manno-heptose, which is utilized for assembly of the lipopolysaccharide inner core. In Gram-positive bacteria the enzyme is involved in biosynthesis of GDP-D-glycero-α-D-manno-heptose, which is required for assembly of S-layer glycoprotein.

Citations: [Kneidinger02, Kneidinger01, Valvano02, Kim09, Taylor08]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:5.3.1.28 , ENZYME:EC:5.3.1.28 , IUBMB-ExplorEnz:EC:5.3.1.28


References

Kim09: Kim MS, Shin DH (2009). "A preliminary X-ray study of sedoheptulose-7-phosphate isomerase from Burkholderia pseudomallei." Acta Crystallogr Sect F Struct Biol Cryst Commun 65(Pt 11);1110-2. PMID: 19923728

Kneidinger01: Kneidinger B, Graninger M, Puchberger M, Kosma P, Messner P (2001). "Biosynthesis of nucleotide-activated D-glycero-D-manno-heptose." J Biol Chem 276(24);20935-44. PMID: 11279237

Kneidinger02: Kneidinger B, Marolda C, Graninger M, Zamyatina A, McArthur F, Kosma P, Valvano MA, Messner P (2002). "Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli." J Bacteriol 184(2);363-9. PMID: 11751812

Taylor08: Taylor PL, Blakely KM, de Leon GP, Walker JR, McArthur F, Evdokimova E, Zhang K, Valvano MA, Wright GD, Junop MS (2008). "Structure and function of GmhA (sedoheptulose 7-phosphate isomerase): A critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants." J Biol Chem 283(5):2835-45. PMID: 18056714

Valvano02: Valvano MA, Messner P, Kosma P (2002). "Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides." Microbiology 148(Pt 7);1979-89. PMID: 12101286


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Wed Nov 26, 2014, biocyc14.