|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: (d)CTP diphosphatase
Enzyme Commission Synonyms: (d)CTP pyrophosphohydrolase, (d)CTP diphosphohydrolase, nudG (gene name)
Enzyme Commission Summary:
The enzyme, characterized from the bacterium Escherichia coli, is specific for the pyrimidine nucleotides CTP and dCTP. It also acts on 5-methyl-dCTP, 5-hydroxy-CTP and 8-hydroxy-dGTP.
Instance reactions of [a nucleoside triphosphate + H2O → a nucleoside 5'-monophosphate + diphosphate + H+] (22.214.171.124):
i1: ITP + H2O → IMP + diphosphate + H+ (126.96.36.199)
i2: XTP + H2O → XMP + diphosphate + H+ (188.8.131.52)
i3: ATP + H2O → AMP + diphosphate + H+ (184.108.40.206)
i4: dTTP + H2O → dTMP + diphosphate + H+ (220.127.116.11)
i5: UTP + H2O → UMP + diphosphate + H+ (18.104.22.168)
i6: dCTP + H2O → dCMP + diphosphate + H+ (22.214.171.124/126.96.36.199/188.8.131.52)
i7: CTP + H2O → CMP + diphosphate + H+ (184.108.40.206)
i8: dATP + H2O → dAMP + diphosphate + H+ (220.127.116.11)
i9: dUTP + H2O → dUMP + diphosphate + H+ (18.104.22.168/22.214.171.124)
i10: dGTP + H2O → dGMP + diphosphate + H+ (126.96.36.199)
i11: dITP + H2O → dIMP + diphosphate + H+ (188.8.131.52)
Fujikawa02: Fujikawa K, Kasai H (2002). "The oxidized pyrimidine ribonucleotide, 5-hydroxy-CTP, is hydrolyzed efficiently by the Escherichia coli recombinant Orf135 protein." DNA Repair (Amst) 1(7);571-6. PMID: 12509230
Iida05: Iida E, Satou K, Mishima M, Kojima C, Harashima H, Kamiya H (2005). "Amino acid residues involved in substrate recognition of the Escherichia coli Orf135 protein." Biochemistry 44(15);5683-9. PMID: 15823026
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