|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name for 18.104.22.168: nucleoside-triphosphate diphosphatase
Enzyme Commission Synonyms for 22.214.171.124: nucleoside-triphosphate pyrophosphatase
Enzyme Commission Primary Name for 126.96.36.199: (d)CTP diphosphatase
Enzyme Commission Synonyms for 188.8.131.52: (d)CTP pyrophosphohydrolase, (d)CTP diphosphohydrolase, nudG (gene name)
Enzyme Commission Summary for 184.108.40.206:
May be identical with EC 220.127.116.11 nucleotide diphosphatase.
Enzyme Commission Summary for 18.104.22.168:
The enzyme, characterized from the bacterium Escherichia coli, is specific for the pyrimidine nucleotides CTP and dCTP. It also acts on 5-methyl-dCTP, 5-hydroxy-CTP and 8-hydroxy-dGTP.
Instance reactions of [a nucleoside triphosphate + H2O → a nucleoside 5'-monophosphate + diphosphate + H+] (22.214.171.124):
i1: dGTP + H2O → dGMP + diphosphate + H+ (126.96.36.199)
i2: dATP + H2O → dAMP + diphosphate + H+ (188.8.131.52)
i3: dUTP + H2O → dUMP + diphosphate + H+ (184.108.40.206/220.127.116.11)
i4: XTP + H2O → XMP + diphosphate + H+ (18.104.22.168)
i5: CTP + H2O → CMP + diphosphate + H+ (22.214.171.124/126.96.36.199)
i6: dITP + H2O → dIMP + diphosphate + H+ (188.8.131.52)
i7: ATP + H2O → AMP + diphosphate + H+ (184.108.40.206)
i8: ITP + H2O → IMP + diphosphate + H+ (220.127.116.11)
i9: dCTP + H2O → dCMP + diphosphate + H+ (18.104.22.168/22.214.171.124/126.96.36.199)
i10: UTP + H2O → UMP + diphosphate + H+ (188.8.131.52)
i11: dTTP + H2O → dTMP + diphosphate + H+ (184.108.40.206)
Chern69: Chern CJ, MacDonald AB, Morris AJ (1969). "Purification and properties of a nucleoside triphosphate pyrophosphohydrolase from red cells of the rabbit." J Biol Chem 244(20);5489-95. PMID: 4310599
Fujikawa02: Fujikawa K, Kasai H (2002). "The oxidized pyrimidine ribonucleotide, 5-hydroxy-CTP, is hydrolyzed efficiently by the Escherichia coli recombinant Orf135 protein." DNA Repair (Amst) 1(7);571-6. PMID: 12509230
Iida05: Iida E, Satou K, Mishima M, Kojima C, Harashima H, Kamiya H (2005). "Amino acid residues involved in substrate recognition of the Escherichia coli Orf135 protein." Biochemistry 44(15);5683-9. PMID: 15823026
©2016 SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025-3493