|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions → Transport Energised by P-P Bond Hydrolysis|
|Reactions Classified By Conversion Type → Simple Reactions → Transport Reactions → Transport Energised by P-P Bond Hydrolysis|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 184.108.40.206
Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .
Reaction Locations: inner membrane (sensu Gram-negative Bacteria)
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: polar-amino-acid-transporting ATPase
Enzyme Commission Synonyms: histidine permease
Enzyme Commission Summary:
ABC-type (ATP-binding cassette-type) ATPase, characterised by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. Comprises bacterial enzymes that import His, Arg, Lys, Glu, Gln, Asp, ornithine, octopine and nopaline.
Kuan95: Kuan G, Dassa E, Saurin W, Hofnung M, Saier MH (1995). "Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases." Res Microbiol 146(4);271-8. PMID: 7569321
Nikaido97: Nikaido K, Liu PQ, Ames GF (1997). "Purification and characterization of HisP, the ATP-binding subunit of a traffic ATPase (ABC transporter), the histidine permease of Salmonella typhimurium. Solubility, dimerization, and ATPase activity." J Biol Chem 272(44);27745-52. PMID: 9346917
Walshaw97: Walshaw DL, Lowthorpe S, East A, Poole PS (1997). "Distribution of a sub-class of bacterial ABC polar amino acid transporter and identification of an N-terminal region involved in solute specificity." FEBS Lett 414(2);397-401. PMID: 9315727
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