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Escherichia coli K-12 substr. MG1655 Reaction: 1.14.14.5

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.14.14.5

Enzymes and Genes:
alkanesulfonate monooxygenase, FMNH2-dependent Inferred from experiment : ssuD

In Pathway: two-component alkanesulfonate monooxygenase

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Instance reactions:
1-butanesulfonate + FMNH2 + oxygen → butanal + sulfite + FMN + H2O + 2 H+ (1.14.14.5)

isethionate + FMNH2 + oxygen → glycolaldehyde + sulfite + FMN + H2O + 2 H+ (1.14.14.5)

3-(N-morpholino)propanesulfonate + FMNH2 + oxygen → 3-(N-morpholino)propanal + sulfite + FMN + H2O + 2 H+ (1.14.14.5)

Enzyme Commission Primary Name: alkanesulfonate monooxygenase

Enzyme Commission Synonyms: SsuD, sulfate starvation-induced protein 6, alkanesulfonate,reduced-FMN:oxygen oxidoreductase

Enzyme Commission Summary:
The enzyme from Escherichia coli catalyses the desulfonation of a wide range of aliphatic sulfonates (unsubstituted C1- to C14-sulfonates as well as substituted C2-sulfonates). Does not desulfonate taurine (2-aminoethanesulfonate) or aromatic sulfonates. Does not use FMN as a bound cofactor. Instead, it uses reduced FMN (i.e., FMNH2) as a substrate. FMNH2 is provided by SsuE, the associated FMN reductase (EC 1.5.1.38).

Citations: [Eichhorn99]

Gene-Reaction Schematic: ?

Instance reactions of [an alkanesulfonate + FMNH2 + oxygen → an aldehyde + sulfite + FMN + H2O + 2 H+] (1.14.14.5):
i1: 1-butanesulfonate + FMNH2 + oxygen → butanal + sulfite + FMN + H2O + 2 H+ (1.14.14.5)

i2: isethionate + FMNH2 + oxygen → glycolaldehyde + sulfite + FMN + H2O + 2 H+ (1.14.14.5)

i3: 3-(N-morpholino)propanesulfonate + FMNH2 + oxygen → 3-(N-morpholino)propanal + sulfite + FMN + H2O + 2 H+ (1.14.14.5)

Relationship Links: BRENDA:EC:1.14.14.5 , ENZYME:EC:1.14.14.5 , IUBMB-ExplorEnz:EC:1.14.14.5


References

Eichhorn99: Eichhorn E, van der Ploeg JR, Leisinger T (1999). "Characterization of a two-component alkanesulfonate monooxygenase from Escherichia coli." J Biol Chem 1999;274(38);26639-46. PMID: 10480865


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Thu Dec 18, 2014, BIOCYC13A.