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Escherichia coli K-12 substr. MG1655 Reaction: 1.14.14.5


Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 1.14.14.5

Enzymes and Genes:
alkanesulfonate monooxygenase, FMNH2-dependentInferred from experiment: ssuD

In Pathway: two-component alkanesulfonate monooxygenase

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Instance reactions:
3-(N-morpholino)propanesulfonate + FMNH2 + oxygen → 3-(N-morpholino)propanal + sulfite + FMN + H2O + 2 H+ (1.14.14.5)

isethionate + FMNH2 + oxygen → glycolaldehyde + sulfite + FMN + H2O + 2 H+ (1.14.14.5)

1-butanesulfonate + FMNH2 + oxygen → butanal + sulfite + FMN + H2O + 2 H+ (1.14.14.5)

Enzyme Commission Primary Name: alkanesulfonate monooxygenase

Enzyme Commission Synonyms: SsuD, sulfate starvation-induced protein 6, alkanesulfonate,reduced-FMN:oxygen oxidoreductase

Enzyme Commission Summary:
The enzyme from Escherichia coli catalyses the desulfonation of a wide range of aliphatic sulfonates (unsubstituted C1- to C14-sulfonates as well as substituted C2-sulfonates). Does not desulfonate taurine (2-aminoethanesulfonate) or aromatic sulfonates. Does not use FMN as a bound cofactor. Instead, it uses reduced FMN (i.e., FMNH2) as a substrate. FMNH2 is provided by SsuE, the associated FMN reductase ( EC 1.5.1.38).

Citations: [Eichhorn99]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reactions of [an alkylsulfonate + FMNH2 + oxygen → an aldehyde + sulfite + FMN + H2O + 2 H+] (1.14.14.5):
i1: 3-(N-morpholino)propanesulfonate + FMNH2 + oxygen → 3-(N-morpholino)propanal + sulfite + FMN + H2O + 2 H+ (1.14.14.5)

i2: isethionate + FMNH2 + oxygen → glycolaldehyde + sulfite + FMN + H2O + 2 H+ (1.14.14.5)

i3: 1-butanesulfonate + FMNH2 + oxygen → butanal + sulfite + FMN + H2O + 2 H+ (1.14.14.5)

Relationship Links: BRENDA:EC:1.14.14.5, ENZYME:EC:1.14.14.5, IUBMB-ExplorEnz:EC:1.14.14.5


References

Eichhorn99: Eichhorn E, van der Ploeg JR, Leisinger T (1999). "Characterization of a two-component alkanesulfonate monooxygenase from Escherichia coli." J Biol Chem 1999;274(38);26639-46. PMID: 10480865


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by Pathway Tools version 19.5 (software by SRI International) on Tue Jan 1, 2002, biocyc12.