Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Escherichia coli K-12 substr. MG1655 Reaction: 1.6.5.10

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.6.5.10

Enzymes and Genes:
NADPH quinone reductase Inferred from experiment : mdaB
chromate reductase : yieF
NAD(P)H:quinone oxidoreductase : wrbA
regulator of KefC-mediated potassium transport and quinone oxidoreductase : kefF

Supersedes EC number: 1.6.99.6

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Direct generic reaction:
a quinone + NAD(P)H + H+ → a quinol + NAD(P)+ (1.6.5.2)

Enzyme Commission Primary Name: NADPH dehydrogenase (quinone)

Enzyme Commission Synonyms: reduced nicotinamide adenine dinucleotide phosphate (quinone) dehydrogenase, NADPH oxidase, NADPH2 dehydrogenase (quinone)

Enzyme Commission Summary:
A flavoprotein [Koli69, Hayashi90]. The enzyme from Escherichia coli is specific for NADPH and is most active with quinone derivatives and ferricyanide as electron acceptors [Hayashi96a]. Menaquinone can act as acceptor. The enzyme from hog liver is inhibited by dicoumarol and folic acid derivatives but not by 2,4-dinitrophenol [Koli69].

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:1.6.5.10 , ENZYME:EC:1.6.5.10 , IUBMB-ExplorEnz:EC:1.6.5.10


References

Hayashi90: Hayashi M, Hasegawa K, Oguni Y, Unemoto T (1990). "Characterization of FMN-dependent NADH-quinone reductase induced by menadione in Escherichia coli." Biochim Biophys Acta 1990;1035(2);230-6. PMID: 2118386

Hayashi96a: Hayashi M, Ohzeki H, Shimada H, Unemoto T (1996). "NADPH-specific quinone reductase is induced by 2-methylene-4-butyrolactone in Escherichia coli." Biochim Biophys Acta 1273(2);165-70. PMID: 8611590

Koli69: Koli AK, Yearby C, Scott W, Donaldson KO (1969). "Purification and properties of three separate menadione reductases from hog liver." J Biol Chem 244(4);621-9. PMID: 4388793


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Sat Nov 22, 2014, BIOCYC14B.