Escherichia coli K-12 substr. MG1655 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:
3-hydroxy acid dehydrogenaseInferred from experiment: ydfG
predicted malonic semialdehyde reductaseInferred from experiment: rutE

In Pathway: uracil degradation III

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 3-hydroxypropionate dehydrogenase (NADP+)

Enzyme Commission Synonyms: 3-hydroxypropanoate dehydrogenase (NADP+), 3-hydroxypropionate:NADP+ oxidoreductase

Enzyme Commission Summary:
Catalyses the reduction of malonate semialdehyde to 3-hydroxypropionate, a key step in the 3-hydroxypropionate and the 3-hydroxypropionate/4-hydroxybutyrate cycles, autotrophic CO2 fixation pathways found in some green non-sulfur phototrophic bacteria and archaea, respectively [Strauss93, Berg07]. The enzyme from Chloroflexus aurantiacus is bifunctional, and also catalyses the upstream reaction in the pathway, EC [Hugler02]. Different from EC [3-hydroxypropionate dehydrogenase (NAD+)] by cofactor preference.

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Berg07: Berg IA, Kockelkorn D, Buckel W, Fuchs G (2007). "A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea." Science 318(5857);1782-6. PMID: 18079405

Hugler02: Hugler M, Menendez C, Schagger H, Fuchs G (2002). "Malonyl-coenzyme A reductase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO(2) fixation." J Bacteriol 184(9);2404-10. PMID: 11948153

Strauss93: Strauss G, Fuchs G (1993). "Enzymes of a novel autotrophic CO2 fixation pathway in the phototrophic bacterium Chloroflexus aurantiacus, the 3-hydroxypropionate cycle." Eur J Biochem 215(3);633-43. PMID: 8354269

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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