|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.1688
In Pathway: uracil degradation III
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: 3-hydroxypropionate dehydrogenase (NADP+)
Enzyme Commission Synonyms: 3-hydroxypropanoate dehydrogenase (NADP+), 3-hydroxypropionate:NADP+ oxidoreductase
Enzyme Commission Summary:
Catalyses the reduction of malonate semialdehyde to 3-hydroxypropionate, a key step in the 3-hydroxypropionate and the 3-hydroxypropionate/4-hydroxybutyrate cycles, autotrophic CO2 fixation pathways found in some green non-sulfur phototrophic bacteria and archaea, respectively [Strauss93, Berg07]. The enzyme from Chloroflexus aurantiacus is bifunctional, and also catalyses the upstream reaction in the pathway, EC 22.214.171.124 [Hugler02]. Different from EC 126.96.36.199 [3-hydroxypropionate dehydrogenase (NAD+)] by cofactor preference.
Hugler02: Hugler M, Menendez C, Schagger H, Fuchs G (2002). "Malonyl-coenzyme A reductase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO(2) fixation." J Bacteriol 184(9);2404-10. PMID: 11948153
Strauss93: Strauss G, Fuchs G (1993). "Enzymes of a novel autotrophic CO2 fixation pathway in the phototrophic bacterium Chloroflexus aurantiacus, the 3-hydroxypropionate cycle." Eur J Biochem 215(3);633-43. PMID: 8354269
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