Escherichia coli K-12 substr. MG1655 Reaction: [no EC number assigned]

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical ReactionsProtein-Modification Reactions
Reactions Classified By SubstrateMacromolecule ReactionsProtein-ReactionsProtein-Modification Reactions

In Pathway: PhoQP Two-Component Signal Transduction System, magnesium-dependent

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balance undetermined; a substrate lacks a chemical formula

In this reaction the sensor kinase-phosphotransferase PhoQ autophosphorylates. Based on analogy to other sensor proteins the phosphorylation site is shown as a histidine residue.
Sensor kinase-phosphotransferase PhoQ is a member of the two-component regulatory system PhoQ/PhoP. In E. coli this system is believed to play a role in Mg++, or other divalent cation, starvation response. The PhoQ protein responds to low concentrations of extracellular divalent cations by autophosphorylating and activating the transcription regulator PhoP by transfer of the phosphate group. [Waldburger96, Kasahara92]

Citations: [Pao95 , Parkinson92, Stock90, Parkinson93]

Depressed by: Mg2+


Kasahara92: Kasahara M, Nakata A, Shinagawa H (1992). "Molecular analysis of the Escherichia coli phoP-phoQ operon." J Bacteriol 1992;174(2);492-8. PMID: 1729240

Pao95: Pao GM, Saier MH (1995). "Response regulators of bacterial signal transduction systems: selective domain shuffling during evolution." J Mol Evol 1995;40(2);136-54. PMID: 7699720

Parkinson92: Parkinson JS, Kofoid EC (1992). "Communication modules in bacterial signaling proteins." Annu Rev Genet 1992;26;71-112. PMID: 1482126

Parkinson93: Parkinson JS (1993). "Signal transduction schemes of bacteria." Cell 1993;73(5);857-71. PMID: 8098993

Stock90: Stock JB, Stock AM, Mottonen JM (1990). "Signal transduction in bacteria." Nature 1990;344(6265);395-400. PMID: 2157156

Waldburger96: Waldburger CD, Sauer RT (1996). "Signal detection by the PhoQ sensor-transmitter. Characterization of the sensor domain and a response-impaired mutant that identifies ligand-binding determinants." J Biol Chem 1996;271(43);26630-6. PMID: 8900137

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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